protein

GABPB1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABPB1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections

0Hypotheses

0Analyses

7Outgoing

0Incoming

Summary

Page for GABPB1 Protein

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🔬 Protein Info

Gene Symbol	GABPB1
Full Name	GA-Binding Protein Subunit Beta 1
Aliases	GABPβ1, NRF2, E4TF1-47
Chromosome	21q21.3
Protein Type	ETS transcription factor family
Function	is an important component in the neurobiology of neurodegenerative diseases.
Primary Expression	tissues with high metabolic demand:
Molecular Weight	51 kDa
GeneCards	GABPB1
Human Protein Atlas	GABPB1
Protein Class	ETS transcription factor family
GABPA	Protein complex
NRF1	Co-regulatory
PGC-1α	Transcriptional
TFAM	Promoter binding
Associated Diseases	neurodegeneration
Interactions	TERT
KG Connections	7 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    GABPB1["<b>GABPB1</b>"]
    TERT["TERT"]
    GABPB1 -->|"activates"| TERT
    GABPA["GABPA"]
    GABPB1 -->|"binds"| GABPA
    SURVIVIN["SURVIVIN"]
    GABPB1 -->|"regulates"| SURVIVIN
    TRAIL_R2["TRAIL-R2"]
    GABPB1 -->|"regulates"| TRAIL_R2
    PTEN["PTEN"]
    GABPB1 -->|"upregulates"| PTEN
    miR_21["miR-21"]
    GABPB1 -->|"binds"| miR_21
    PRDX5["PRDX5"]
    GABPB1 -->|"upregulates"| PRDX5
    miR_330_3p["miR-330-3p"]
    GABPB1 -->|"binds"| miR_330_3p
    neurodegeneration["neurodegeneration"]
    GABPB1 -->|"implicated in"| neurodegeneration
    style GABPB1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (7)

Target	Relation	Type	Str
TERT	activates	gene	0.90
TRAIL-R2	regulates	receptor	0.80
PTEN	upregulates	gene	0.80
miR-21	binds	entity	0.80
PRDX5	upregulates	gene	0.80
miR-330-3p	binds	entity	0.80
SURVIVIN	regulates	protein	0.80

Incoming (0)

Source	Relation	Type	Str
No incoming edges

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GABPB1

Understanding Entity Pages

Summary

Wiki Pages (5)

GABPB1 Gene

GABPA - GA Binding Protein Transcription Factor Alpha Subunit

GABPB1 Protein