TTR

Understanding Entity Pages

This page aggregates everything SciDEX knows about TTR: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

TTR is a gene implicated in neurodegeneration research. Key relationships include: therapeutic target, interacts with, associated with. Associated with Als, Inflammation, Ms. Connected to 35 entities in the SciDEX knowledge graph.

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graph TD
    TTR["<b>TTR</b>"]
    GABRD["GABRD"]
    TTR -->|"regulates"| GABRD
    Inflammation{"Inflammation"}
    TTR -->|"therapeutic target"| Inflammation
    Als{"Als"}
    TTR -->|"therapeutic target"| Als
    TTR -->|"associated with"| Als
    Ms{"Ms"}
    TTR -->|"associated with"| Ms
    TTR -->|"therapeutic target"| Ms
    LGALS3["LGALS3"]
    TTR -->|"therapeutic target"| LGALS3
    CTSD["CTSD"]
    TTR -->|"therapeutic target"| CTSD
    GRB2["GRB2"]
    TTR -->|"therapeutic target"| GRB2
    TLR4["TLR4"]
    TTR -->|"therapeutic target"| TLR4
    NFE2L2["NFE2L2"]
    TTR -->|"therapeutic target"| NFE2L2
    RPS6KA1["RPS6KA1"]
    TTR -->|"therapeutic target"| RPS6KA1
    GENES["GENES"]
    GENES -->|"therapeutic target"| TTR
    CAPN1["CAPN1"]
    CAPN1 -->|"therapeutic target"| TTR
    ERK["ERK"]
    ERK -->|"associated with"| TTR
    PIK3CA["PIK3CA"]
    PIK3CA -->|"interacts with"| TTR
    MMP9["MMP9"]
    MMP9 -->|"interacts with"| TTR
    PPARA["PPARA"]
    PPARA -->|"interacts with"| TTR
    IGF1R["IGF1R"]
    IGF1R -->|"interacts with"| TTR
    RELA["RELA"]
    RELA -->|"interacts with"| TTR
    AKT1["AKT1"]
    AKT1 -->|"interacts with"| TTR
    INSR["INSR"]
    INSR -->|"interacts with"| TTR
    style TTR fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0