Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about ESCC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | ESCC |
| Key Genes/Proteins | TP53, RB1, CDKN2A, PIK3CA, NOTCH1, GABRD |
| Related Diseases | HEAT_STIMULATION |
| Related Pathways | Wnt pathway, cell cycle pathway, Notch pathway |
Knowledge base pages for this entity
graph TD
ESCC["ESCC"]
TP53["TP53"] -->|"causes"| ESCC
RB1["RB1"] -->|"causes"| ESCC
CDKN2A["CDKN2A"] -->|"causes"| ESCC
PIK3CA["PIK3CA"] -->|"causes"| ESCC
NOTCH1["NOTCH1"] -->|"causes"| ESCC
Wnt_pathway["Wnt pathway"] -->|"participates in"| ESCC
cell_cycle_pathway["cell cycle pathway"] -->|"participates in"| ESCC
Notch_pathway["Notch pathway"] -->|"participates in"| ESCC| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| TP53 | causes | gene | 0.90 |
| RB1 | causes | gene | 0.90 |
| CDKN2A | causes | gene | 0.90 |
| PIK3CA | causes | gene | 0.90 |
| NOTCH1 | causes | gene | 0.90 |
| GABRD | associated_with | gene | 0.80 |
| Wnt pathway | participates_in | pathway | 0.70 |
| cell cycle pathway | participates_in | pathway | 0.70 |
| Notch pathway | participates_in | pathway | 0.70 |
| HEAT_STIMULATION | activates | phenotype | 0.64 |
| KCNK2 | inhibits | gene | 0.56 |
| EFNB1 | implicated_in | gene | 0.50 |
| TP53 | implicated_in | gene | 0.50 |
| ERK | implicated_in | gene | 0.50 |
| AKT | implicated_in | gene | 0.50 |
| SRC | implicated_in | gene | 0.50 |
| EPHB4 | implicated_in | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||