Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GDI1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GDI1 |
| Full Name | GDP Dissociation Inhibitor 1 |
| Chromosome | Xq28 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | peripheral tissues including heart, lung, and kidney[^2] |
| Molecular Weight | 50 kDa |
| Amino Acids | 447 aa |
| Exons | 11 |
| UniProt ID | P31160 |
| NCBI Gene ID | 2651 |
| Ensembl ID | ENSG00000203837 |
| OMIM | 300104 |
| GeneCards | GDI1 |
| Human Protein Atlas | GDI1 |
| Associated Diseases | neurodegeneration |
| Interactions | RAB3A, LRRK2, SYNAPTOPHYSIN, PARKINSON'S DISEASE |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GDI1["<b>GDI1</b>"]
Parkinson{"Parkinson"}
GDI1 -->|"interacts with"| Parkinson
Als{"Als"}
GDI1 -->|"interacts with"| Als
Ms{"Ms"}
GDI1 -->|"interacts with"| Ms
RAB3A["RAB3A"]
GDI1 -->|"interacts with"| RAB3A
LRRK2["LRRK2"]
GDI1 -->|"interacts with"| LRRK2
neurodegeneration["neurodegeneration"]
GDI1 -->|"implicated in"| neurodegeneration
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"interacts with"| GDI1
SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
SYNAPTOPHYSIN -->|"interacts with"| GDI1
style GDI1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Source | Relation | Type | Str |
|---|---|---|---|
| SYNAPTOPHYSIN | interacts_with | gene | 0.60 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||