gene

RAB3A

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAB3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

44Connections
0Hypotheses
0Analyses
29Outgoing
15Incoming
0Experiments

Summary

RAB3A is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with ALS, Als, Ms. Connected to 30 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolRAB3A
Full NameRas-Related Protein Rab-3A
Functionis a synaptic vesicle-associated small GTPase that plays a central role in regulating neurotransmitter release[@raba2018][@rab2020].
Subcellular Localization</th><td>Synaptic Vesicles, Presynaptic Terminal</td></tr>
Molecular Weight25 kDa
Amino Acids35 aa
PathwaysSynaptic Vesicle Exocytosis
GeneCardsRAB3A
Human Protein AtlasRAB3A
Associated DiseasesALS
InteractionsRAB27B, LRRK2, AXON, PARKINSON, Raf, SYNAPTOPHYSIN
KG Connections44 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

RAB3A — Ras-Related Protein Rab-3A

gene · 661 words

CNTN6 — Contactin 6

gene · 4611 words

CNTN3 — Contactin 3

gene · 4253 words

Synaptic Dysfunction Pathway

mechanism · 3282 words

Synaptic Vesicle Cycle

mechanism · 3096 words

RAB4B Gene

gene · 2951 words

Pathway Diagram

graph TD
    RAB3A["<b>RAB3A</b>"]
    Als{"Als"}
    RAB3A -->|"associated with"| Als
    Parkinson{"Parkinson"}
    RAB3A -->|"interacts with"| Parkinson
    RAB3A -->|"interacts with"| Als
    Ms{"Ms"}
    RAB3A -->|"interacts with"| Ms
    ALS{"ALS"}
    RAB3A -->|"associated with"| ALS
    Exocytosis(["Exocytosis"])
    RAB3A -->|"activates"| Exocytosis
    RAB3B["RAB3B"]
    RAB3A -->|"associated with"| RAB3B
    RAB10["RAB10"]
    RAB3A -->|"associated with"| RAB10
    RAB11B["RAB11B"]
    RAB3A -->|"associated with"| RAB11B
    RAB3C["RAB3C"]
    RAB3A -->|"associated with"| RAB3C
    RAB5A["RAB5A"]
    RAB3A -->|"associated with"| RAB5A
    RAB5["RAB5"]
    RAB3A -->|"associated with"| RAB5
    RAB4B["RAB4B"]
    RAB4B -->|"associated with"| RAB3A
    RAB27B["RAB27B"]
    RAB27B -->|"activates"| RAB3A
    RAB3C -->|"associated with"| RAB3A
    RAB5 -->|"associated with"| RAB3A
    RAB3B -->|"associated with"| RAB3A
    RAB5A -->|"associated with"| RAB3A
    RAB11B -->|"associated with"| RAB3A
    RAB10 -->|"associated with"| RAB3A
    PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
    PARKINSON_S_DISEASE -->|"interacts with"| RAB3A
    SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
    SYNAPTOPHYSIN -->|"interacts with"| RAB3A
    GDI1["GDI1"]
    GDI1 -->|"interacts with"| RAB3A
    RAB27B -->|"causes"| RAB3A
    style RAB3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (29)

TargetRelationTypeStr
Synaptic Vesicle Exocytosisinvolved_inprocess0.95
RAB27Binteracts_withprotein0.85
Alsassociated_withdisease0.65
Parkinsoninteracts_withdisease0.65
Alsinteracts_withdisease0.65

Incoming (15)

SourceRelationTypeStr
RAB-GDImodulatesprotein0.85
RAB4Bassociated_withgene0.60
RAB27Bactivatesgene0.60
RAB3Cassociated_withgene0.60
RAB5associated_withgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found