Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about RAB3A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
RAB3A is a gene implicated in neurodegeneration research. Key relationships include: associated with, interacts with, activates. Associated with ALS, Als, Ms. Connected to 30 entities in the SciDEX knowledge graph.
| Gene Symbol | RAB3A |
| Full Name | Ras-Related Protein Rab-3A |
| Function | is a synaptic vesicle-associated small GTPase that plays a central role in regulating neurotransmitter release[@raba2018][@rab2020]. |
| Subcellular Localization | </th><td>Synaptic Vesicles, Presynaptic Terminal</td></tr> |
| Molecular Weight | 25 kDa |
| Amino Acids | 35 aa |
| Pathways | Synaptic Vesicle Exocytosis |
| GeneCards | RAB3A |
| Human Protein Atlas | RAB3A |
| Associated Diseases | ALS |
| Interactions | RAB27B, LRRK2, AXON, PARKINSON, Raf, SYNAPTOPHYSIN |
| KG Connections | 44 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
RAB3A["<b>RAB3A</b>"]
Als{"Als"}
RAB3A -->|"associated with"| Als
Parkinson{"Parkinson"}
RAB3A -->|"interacts with"| Parkinson
RAB3A -->|"interacts with"| Als
Ms{"Ms"}
RAB3A -->|"interacts with"| Ms
ALS{"ALS"}
RAB3A -->|"associated with"| ALS
Exocytosis(["Exocytosis"])
RAB3A -->|"activates"| Exocytosis
RAB3B["RAB3B"]
RAB3A -->|"associated with"| RAB3B
RAB10["RAB10"]
RAB3A -->|"associated with"| RAB10
RAB11B["RAB11B"]
RAB3A -->|"associated with"| RAB11B
RAB3C["RAB3C"]
RAB3A -->|"associated with"| RAB3C
RAB5A["RAB5A"]
RAB3A -->|"associated with"| RAB5A
RAB5["RAB5"]
RAB3A -->|"associated with"| RAB5
RAB4B["RAB4B"]
RAB4B -->|"associated with"| RAB3A
RAB27B["RAB27B"]
RAB27B -->|"activates"| RAB3A
RAB3C -->|"associated with"| RAB3A
RAB5 -->|"associated with"| RAB3A
RAB3B -->|"associated with"| RAB3A
RAB5A -->|"associated with"| RAB3A
RAB11B -->|"associated with"| RAB3A
RAB10 -->|"associated with"| RAB3A
PARKINSON_S_DISEASE["PARKINSON'S DISEASE"]
PARKINSON_S_DISEASE -->|"interacts with"| RAB3A
SYNAPTOPHYSIN["SYNAPTOPHYSIN"]
SYNAPTOPHYSIN -->|"interacts with"| RAB3A
GDI1["GDI1"]
GDI1 -->|"interacts with"| RAB3A
RAB27B -->|"causes"| RAB3A
style RAB3A fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Synaptic Vesicle Exocytosis | involved_in | process | 0.95 |
| RAB27B | interacts_with | protein | 0.85 |
| Als | associated_with | disease | 0.65 |
| Parkinson | interacts_with | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Ms | interacts_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| RAB3B | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB27B | activates | gene | 0.60 |
| LRRK2 | activates | gene | 0.60 |
| RAB4B | associated_with | gene | 0.60 |
| Synaptic Vesicle | causes | pathway | 0.60 |
| RAB27B | causes | gene | 0.60 |
| Exocytosis | activates | pathway | 0.60 |
| Exocytosis | causes | pathway | 0.60 |
| AND | causes | gene | 0.60 |
| Fus | associated_with | protein | 0.60 |
| App | associated_with | protein | 0.60 |
| AXON | activates | gene | 0.60 |
| PARKINSON | phosphorylates | gene | 0.60 |
| Neuron | activates | cell_type | 0.60 |
| Raf | phosphorylates | protein | 0.60 |
| RAB27B | associated_with | protein | 0.50 |
| Proteins | associated_with | protein | 0.50 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RAB-GDI | modulates | protein | 0.85 |
| RAB4B | associated_with | gene | 0.60 |
| RAB27B | activates | gene | 0.60 |
| RAB3C | associated_with | gene | 0.60 |
| RAB5 | associated_with | gene | 0.60 |
| RAB3B | associated_with | gene | 0.60 |
| RAB5A | associated_with | gene | 0.60 |
| RAB11B | associated_with | gene | 0.60 |
| RAB10 | associated_with | gene | 0.60 |
| SYNAPTOPHYSIN | interacts_with | gene | 0.60 |
| GDI1 | interacts_with | gene | 0.60 |
| RAB27B | causes | gene | 0.60 |
| RAB27B | associated_with | entity | 0.60 |
| RAB27B | expressed_in | entity | 0.60 |
| PARKINSON'S DISEASE | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||