Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GI/O signaling: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Target | Relation | Type | Str |
|---|---|---|---|
| SNCA | upregulates | gene | 0.80 |
| neuronal activity | inhibits | process | 0.70 |
| Source | Relation | Type | Str |
|---|---|---|---|
| RGS6 | inhibits | gene | 0.95 |
| RGS6 | inhibits | gene | 0.95 |
| DRD2 | activates | gene | 0.90 |
| D2 AUTORECEPTOR | activates | receptor | 0.85 |
| D2 autoreceptor | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Pharmacologic modulation of D2 autoreceptor-Gi/o signaling i | 0.420 | neurodegeneration | Does RGS6 upregulation or D2 autorecepto |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-25 | 5 hypotheses Top: 0.530
neurodegeneration | 2026-04-17 | 7 hypotheses Top: 0.559
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.54 · 2026-04-25
closed · Rounds: 4 · Score: 0.50 · 2026-04-18
Hypotheses and analyses mentioning GI/O signaling in their description or question text
No additional research found