Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GPR3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Gene Symbol | GPR3 |
| Protein Type | Receptor |
| Function | GPR3 is a G protein-coupled receptor that is constitutively active and signals through Gs proteins to increase intracellular cAMP levels[@thathiah2009]. |
| Primary Expression | neurons and glial cells and has been shown to promote neuronal survival and protect against amyloid-beta toxicity[@thathiah2009a] |
| Pathways | MAPK signaling |
| Ensembl ID | ENSG00000170270 |
| GeneCards | GPR3 |
| Human Protein Atlas | GPR3 |
| Constitutive activity | Unlike many GPCRs, GPR3 maintains high basal activity without ligand binding |
| Gs coupling | Primary G protein coupling leads to adenylate cyclase activation and increased cAMP |
| β-arrestin pathways | Engages β-arrestin mediated signaling independent of G protein pathways |
| ERK1/2 activation | Triggers MAPK signaling cascade involved in cell survival |
| Neuronal survival | Promotes pro-survival signaling through cAMP/PKA pathway |
| Amyloid clearance | Upregulates neprilysin and other amyloid-degrading enzymes |
| Synaptic plasticity | Modulates cAMP signaling at synapses |
| Associated Diseases | neurodegeneration |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
graph TD
GPR3["GPR3"]
neurodegeneration["neurodegeneration"]
GPR3 -->|"implicated_in"| neurodegeneration
style GPR3 fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Microglial Efferocytosis Enhancement via GPR32 Superagonists | 0.704 | neurodegeneration | Neuroinflammation resolution mechanisms |
Scientific analyses that reference this entity
neuroinflammation | 2026-04-13 | 2 hypotheses Top: 0.831
pharmacology | 2026-04-11 | 0 hypotheses
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| s:** - GPR32 knockout in microglia should worsen neuroinflammation if | falsification | Neuroinflammation | 0.400 | 0.50 | cell_line | proposed | $80,000 |
| FTD Microglia Role: Protective vs Destructive Mechanism Study | validation | Neuroinflammation | 0.400 | 0.50 | human | proposed | $2,960,000 |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| PAD4 promotes macrophage migration to aggravate tubulointerstitial injury in dia [PMID:41054305] | Xiong Y, Li R, Chen X, Peng C, Zeng Q, Z | Mol Ther | 2026 | 1 |
| Chemerin-CMKLR1 differentially mediated OGD/R-induced mitochondrial dysfunction, [PMID:41151300] | Long PY, Tang Z, Cai N, Yan ZQ, Gao X, W | Biomed Pharmacother | 2025 | 1 |
| The chemerin-CMKLR1 axis limits thermogenesis by controlling a beige adipocyte/I [PMID:34330814] | Lin Y, Xiao L, Cai Q, Zhu C, Li S, Li B, | Sci Immunol | 2021 | 1 |
| Microglial Aβ receptors in Alzheimer's disease. [PMID:25149075] | Yu Y, Ye RD | Cell Mol Neurobiol | 2015 | 1 |
| Molecular Signaling and Biased Agonism of the CHEMR23 Receptor: Implications for [PMID:41486998] | ["Neprelyuk O", "Romanenko I", "Irza O", | Current protein & peptide scie | 2026 | 0 |
| Receptor-Mediated Shuttling of a D-Amino Acid Peptide Achieves High Nanomolar Cy [PMID:41422545] | ["List M", "Beck-Sickinger A"] | Journal of the American Chemic | 2026 | 0 |
| Follicle-dependent differential localization of adipokines in the letrozole-indu [PMID:41857436] | ["Dutta A", "Gurusubramanian G", "Roy V" | Histochemistry and cell biolog | 2026 | 0 |
| Targeting the CMKLR1-Mediated Signaling Rebalances Immunometabolism State in Mid [PMID:41538650] | ["Zhu Z", "Du F", "Liu Y", "Yang J", "Ge | Advanced science (Weinheim, Ba | 2026 | 0 |
| Biomarkers of haemodynamic severity of systemic sclerosis-associated pulmonary a [PMID:36600187] | ["Sanges S", "Rice L", "Tu L", "Valenzi | Annals of the rheumatic diseas | 2023 | 0 |
| The Chemerin/CMKLR1 Axis Is Involved in the Recruitment of Microglia to Aβ Depos [PMID:36012305] | Chen Y, Liu Z, Gong P, Zhang H, Chen Y, | International journal of molec | 2022 | 0 |
| Chemerin partly mediates tumor-inhibitory effect of all-trans retinoic acid via [PMID:31063220] | Song Y, Yin W, Dan Y, Sheng J, Zeng Y, H | Immunology | 2019 | 0 |
| Chemerin/ChemR23 axis promotes inflammation of glomerular endothelial cells in d [PMID:30784180] | ["Shang J", "Wang L", "Zhang Y", "Zhang | Journal of cellular and molecu | 2019 | 0 |
| Targeting the D Series Resolvin Receptor System for the Treatment of Osteoarthri [PMID:27860453] | ["Huang J", "Burston J", "Li L", "Ashraf | Arthritis & rheumatology (Hobo | 2017 | 0 |
| Vitamin D and the omega-3 fatty acids control serotonin synthesis and action, pa [PMID:25713056] | ["Patrick R", "Ames B"] | FASEB journal : official publi | 2015 | 0 |
| The chemerin receptor CMKLR1 is a functional receptor for amyloid-β peptide. [PMID:25079809] | Peng L, Yu Y, Liu J, Li S, He H, Cheng N | Journal of Alzheimer's disease | 2015 | 0 |
| Intestinal inhibition of the Na+/H+ exchanger 3 prevents cardiorenal damage in r [PMID:24622516] | ["Spencer A", "Labonte E", "Rosenbaum D" | Science translational medicine | 2014 | 0 |
| Overexpression of Ras homologous C (RhoC) induces malignant transformation of he [PMID:23382905] | ["Xie S", "Zhu M", "Lv G", "Geng Y", "Ch | PloS one | 2013 | 0 |
| International Union of Basic and Clinical Pharmacology. LXXXVIII. G protein-coup [PMID:23686350] | ["Davenport A", "Alexander S", "Sharman | Pharmacological reviews | 2013 | 0 |
| Resolvins: natural agonists for resolution of pulmonary inflammation. [PMID:20887750] | Uddin M, Levy BD | Progress in lipid research | 2011 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.30 · 2026-04-21
closed · Rounds: 4 · Score: 0.79 · 2026-04-13
Hypotheses and analyses mentioning GPR3 in their description or question text
No additional research found