| Gene Symbol | GPR37 |
| Aliases | Parmethin |
| Chromosome | 7q31.3 |
| Protein Type | Gpcr |
| Target Class | Gpcr |
| Function | GPR37 agonists or modulators would activate the receptor to promote dopaminergic neuron survival and neuroprotection, counteracting the neurodegeneration characteristic of Parkinson's disease. Liga... |
| Mechanism of Action | GPR37 agonists or modulators would activate the receptor to promote dopaminergic neuron survival and neuroprotection, counteracting the neurodegeneration characteristic of Parkinson's disease. Ligands binding to GPR37 would enhance G-protein signaling cascades that support neuronal viability and function. |
| Primary Expression | the central nervous system |
| Subcellular Localization | </strong></td><td>Endoplasmic reticulum, Plasma membrane</td></tr> |
| Druggability | Low (0.30) |
| Clinical Stage | Approved |
| Molecular Weight | 52 kDa |
| Amino Acids | 462 aa |
| Pathways | Apoptosis, Neuroinflammatory, Oxidative Stress |
| UniProt ID | O15354 |
| Ensembl ID | ENSG00000170370 |
| GeneCards | GPR37 |
| Human Protein Atlas | GPR37 |
| Associated Diseases | ALS, ALZHEIMER, Alzheimer's disease, Cancer, INFLAMMATION, Infection |
| Known Drugs/Compounds | Prosaposin, TX14(A) |
| Interactions | IL6, PSAP, SMAD4, CTSD, PD1, PI3K |
| SciDEX Target | View Target Profile (10 clinical trials) |
| SciDEX Hypotheses | Oligodendrocyte Protectin D1 Mimetic for Myelin Re |
| KG Connections | 343 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |