Contents

GPR3 Modulators for Neurodegeneration

🔬 Protein Info

Gene Symbol	ent-gene-8151ff95
Constitutively Active	Unlike most GPCRs, GPR3 maintains high basal activity without ligand binding
Gs-coupled	Activates adenylate cyclase, increasing cAMP levels
Brain-enriched	High expression in hippocampus, cortex, striatum, and cerebellum
Beta-arrestin Pathway	Signals through both Gs and beta-arrestin pathways
KG Connections	2 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

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