Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GRIP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | GRIP1 |
| Full Name | GRIP1 — Glutamate Receptor Interacting Protein 1 |
| Chromosome | 7q31.3 |
| Protein Type | Gene |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Subcellular Localization | postsynaptic densities of excitatory synapses on dendritic spines. GRIP1 expression peak |
| Molecular Weight | 120 kDa |
| Amino Acids | 112 aa |
| Exons | 29 |
| UniProt ID | O75177 |
| NCBI Gene ID | 9439 |
| Ensembl ID | ENSG00000155966 |
| GeneCards | GRIP1 |
| Human Protein Atlas | GRIP1 |
| Associated Diseases | Autism spectrum disorder, intellectual disability, epilepsy, Alzheimer's disease, Parkinson's disease |
| KG Connections | 1 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GRIP1["GRIP1"]
style GRIP1 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
astrocytes["astrocytes"]
neurodegeneration["neurodegeneration"]
GRIP1 -->|"expressed_in"| astrocytes
GRIP1 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class astrocytes mechanism
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| astrocytes | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||
Multi-agent debates referencing this entity
No debates reference this entity