gene

HTR4

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HTR4: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

6Connections

0Hypotheses

0Analyses

5Outgoing

1Incoming

0Experiments

0Debates

Summary

Page for HTR4 Gene

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🧬 Gene Info

Gene Symbol	HTR4
Full Name	5-Hydroxytryptamine Receptor 4
Chromosome	5q31.3
Protein Type	Receptor
Function	The HTR4 gene encodes the 5-hydroxytryptamine receptor 4 (5-HT4), a G-protein coupled receptor that activates Gs proteins, stimulating adenylyl cyclase and increasing cAMP production.
Primary Expression	hippocampus, basal ganglia, and cortex
UniProt ID	[Q9Y4XE8](https://www.uniprot.org/uniprotkb/Q9Y4XE8)
Ensembl ID	ENSG00000176049
GeneCards	HTR4
Human Protein Atlas	HTR4
Associated Diseases	neurodegeneration
KG Connections	6 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

HTR4 Gene

gene · 761 words

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Pathway Diagram

flowchart TD
    N0["HTR4"]
    N1["SOD1"]
    N1 -->|"regulates"| N0
    N2["ALS"]
    N0 -->|"regulates"| N2
    N3["Inflammation"]
    N0 -->|"regulates"| N3
    N4["Amyotrophic Lateral Sclerosis"]
    N0 -->|"regulates"| N4
    N5["Neuroinflammation"]
    N0 -->|"regulates"| N5
    N6["Neuron"]
    N0 -->|"expressed in"| N6
    N7["neurodegeneration"]
    N0 -->|"implicated in"| N7

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    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef cell_type fill:#2a1a2a,stroke:#ab47bc,color:#e0e0e0
    classDef phenotype fill:#2a2a1a,stroke:#ffa726,color:#e0e0e0
    classDef process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef biological_process fill:#1a2a2a,stroke:#66bb6a,color:#e0e0e0
    classDef concept fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    classDef entity fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef therapeutic fill:#1a2a2a,stroke:#26c6da,color:#e0e0e0
    classDef index fill:#1a1a2a,stroke:#7986cb,color:#e0e0e0
    class N0 gene
    class N1 gene
    class N2 disease
    class N3 disease
    class N4 disease
    class N5 disease
    class N6 cell_type

Outgoing (5)

Target	Relation	Type	Str
ALS	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Neuroinflammation	regulates	disease	0.65
Neuron	expressed_in	cell_type	0.55

Incoming (1)

Source	Relation	Type	Str
SOD1	regulates	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning HTR4 in their description or question text

No additional research found