Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HTT, DMPK, repeat-containing transcripts: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| NURR1, PITX3, neuronal identity transcription factors | debate_co_mention | gene | 0.45 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | debate_co_mention | gene | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| RNA | debate_co_mention | gene | 0.45 |
| benchmark_ot_ad_answer_key:HTT, DMPK, REPEAT-CONTAINING TRANSCRIPTS | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF, CREB1, synaptic plasticity genes | debate_co_mention | gene | 0.45 |
| Cell-type-specific essential genes | debate_co_mention | gene | 0.45 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
| HMGCR, LDLR, APOE regulatory regions | debate_co_mention | gene | 0.45 |
| benchmark_ot_ad_answer_key:HTT, DMPK, REPEAT-CONTAINING TRANSCRIPTS | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Trinucleotide Repeat Sequestration via CRISPR-Guided RNA Tar | 0.479 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Long somatic DNA-repeat expansion drives neurodegeneration in Huntington's disea [PMID:39824182] | ["Handsaker R", "Kashin S", "Reed N", "T | Cell | 2025 | 0 |
| Magnetic control of tokamak plasmas through deep reinforcement learning. [PMID:35173339] | Degrave J, Felici F, Buchli J, Neunert M | Nature | 2022 | 0 |
| Cardiomyocyte-derived calcitonin regulates atrial fibrosis and AF. [PMID:33199879] | Fernández-Ruiz I | Nature reviews. Cardiology | 2021 | 0 |
| SMS2 deficiency impairs PKCδ-regulated B cell tolerance in the germinal center. [PMID:34469734] | Ou P, Stanek A, Huan Z, Roman CAJ, Huan | Cell reports | 2021 | 0 |
| ATTEC: a potential new approach to target proteinopathies. [PMID:31690177] | ["Li Z", "Zhu C", "Ding Y", "Fei Y", "Lu | Autophagy | 2020 | 0 |
| Multiple clinical features of Huntington's disease correlate with mutant HTT gen [PMID:29956026] | ["Podvin S", "Reardon H", "Yin K", "Mosi | Journal of neurology | 2019 | 0 |
| HTT gene intermediate alleles in neurodegeneration: evidence for association wit [PMID:30583877] | ["Men\u00e9ndez-Gonz\u00e1lez M", "Clari | Neurobiology of aging | 2019 | 0 |