gene

RANK

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RANK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

408Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

0Experiments

0Debates

Summary

RANK is a gene implicated in neurodegeneration research. Key relationships include: activates, associated with, regulates. Associated with ALS, Aging, Als. Connected to 235 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	RANK (TNFRSF11A)
Full Name	TNF Receptor Superfamily Member 11A
Aliases	TNFRSF11A
Chromosome	18q21.33
Protein Type	Receptor
Function	RANK is a type I transmembrane protein expressed primarily on osteoclast precursors, dendritic cells, and activated T cells[@anderson1997].
Pathways	NF-κB
UniProt ID	Q9Y275
NCBI Gene ID	26986
Ensembl ID	ENSG00000141655
OMIM	603799
Osteoclast Differentiation	RANKL binding activates NF-κB, c-Fos, and NFATc1 signaling cascades that drive osteoclast precursor cells to mature, functional osteoclasts[@hsu1999]
Bone Remodeling	The RANK/RANKL/OPG axis is the primary regulator of bone resorption and formation balance
Calcium Homeostasis	Through osteoclast activity, RANK signaling indirectly regulates serum calcium levels
Dendritic Cell Survival	RANK signaling promotes dendritic cell survival and maturation, essential for antigen presentation[@josien1999]
Associated Diseases	Aging, Als, Autoimmune, Cancer, Hypertension
Interactions	Actin, AGING, ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AND
KG Connections	408 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RANK — AlphaFold Q9Y275 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

RANK (TNFRSF11A)

gene · 723 words

→

RANKL (TNFSF11)

gene · 678 words

→

Pathway Diagram

graph TD
    RANK["RANK"]
    RANK -->|"activates"| Neurodegeneration["Neurodegeneration"]
    RANK -->|"activates"| Ms["Ms"]
    RANK -->|"activates"| Als["Als"]
    RANK -->|"interacts"| Alzheimer["Alzheimer"]
    RANK -->|"activates"| Cancer["Cancer"]
    RANK -->|"activates"| Tumor["Tumor"]
    RANK -->|"activates"| Senescence["Senescence"]
    RANKL["RANKL"] -->|"activates"| RANK
    VCP["VCP"] -->|"activates"| RANK
    JUN["JUN"] -->|"activates"| RANK
    SQSTM1["SQSTM1"] -->|"activates"| RANK
    TYROBP["TYROBP"] -->|"activates"| RANK
    ATF4["ATF4"] -->|"regulates"| RANK
    GAIN["GAIN"] -->|"activates"| RANK
    HNRNPA2B1["HNRNPA2B1"] -->|"activates"| RANK
    HNRNPA1["HNRNPA1"] -->|"activates"| RANK

Outgoing (240)

Target	Relation	Type	Str
NFKB	activates	pathway	0.95
Nuclear Factor Kappa B	activates	pathway	0.90
Osteoporosis	activates	disease	0.75
Als	biomarker_for	disease	0.75
Inflammation	regulates	disease	0.75
Cancer	therapeutic_target	disease	0.75
Tumor	biomarker_for	disease	0.75
Ischemia	expressed_in	disease	0.75
Inflammation	biomarker_for	disease	0.75
Als	activates	disease	0.75
Senescence	activates	disease	0.75
Als	associated_with	disease	0.75
Apoptosis	therapeutic_target	pathway	0.70
Mapk	therapeutic_target	pathway	0.70
Differentiation	activates	pathway	0.70
Aging	activates	disease	0.65
Ovarian Cancer	regulates	disease	0.65
Inflammation	activates	disease	0.65
Neuroinflammation	biomarker_for	disease	0.65
Als	expressed_in	disease	0.65
ALS	activates	disease	0.65
Alzheimer	activates	disease	0.65
Carcinoma	expressed_in	disease	0.65
ALS	regulates	disease	0.65
Neurodegeneration	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Alzheimer	biomarker_for	disease	0.65
Neurodegeneration	biomarker_for	disease	0.65
Cancer	regulates	disease	0.65
Tumor	regulates	disease	0.65
Ms	expressed_in	disease	0.65
Neurodegeneration	associated_with	disease	0.65
Amyotrophic Lateral Sclerosis	therapeutic_target	disease	0.65
Cancer	expressed_in	disease	0.65
Als	protects_against	disease	0.65
Aging	associated_with	disease	0.65
Tumor	activates	disease	0.65
Ms	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Alzheimer	interacts_with	disease	0.65
Ms	interacts_with	disease	0.65
Tumor	expressed_in	disease	0.65
Aging	interacts_with	disease	0.65
Neurodegeneration	activates	disease	0.65
Hypertension	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Als	therapeutic_target	disease	0.65
Stroke	associated_with	disease	0.65

Incoming (168)

Source	Relation	Type	Str
TNFRSF11A	associated_with	gene	1.00
TNFRSF11A	encodes	gene	0.95
RANKL	binds	protein	0.95
OSTEOPROTEGERIN	inhibits	protein	0.90
RANKL	regulates	gene	0.80
RANKL	activates	protein	0.72
TNF	regulates	gene	0.70
HNRNPA2B1	associated_with	gene	0.60
ATF4	regulates	gene	0.60
JUN	activates	gene	0.60
BECLIN1	inhibits	gene	0.60
HNRNPA1	associated_with	gene	0.60
HSPA5	regulates	gene	0.60
ATF4	therapeutic_target	gene	0.60
TRAF6	associated_with	gene	0.60
HNRNPA1	activates	gene	0.60
TYROBP	activates	gene	0.60
TLR4	associated_with	gene	0.60
PI3K	therapeutic_target	gene	0.60
AKT	therapeutic_target	gene	0.60
SOD2	expressed_in	gene	0.60
ALDH2	expressed_in	gene	0.60
ABCD3	associated_with	gene	0.60
TIA1	activates	gene	0.60
SIRT7	interacts_with	gene	0.60
HMGCR	regulates	gene	0.60
HNRNPA2B1	activates	gene	0.60
CFOS	activates	gene	0.60
NEFL	biomarker_for	gene	0.60
TAU	biomarker_for	gene	0.60
MTOR	interacts_with	gene	0.60
ERK1	activates	gene	0.60
BECN1	regulates	gene	0.60
DLK	activates	gene	0.60
APP	activates	gene	0.60
STAT3	associated_with	gene	0.60
PPARA	associated_with	gene	0.60
IFNG	associated_with	gene	0.60
PI3K	associated_with	gene	0.60
PPARG	associated_with	gene	0.60
IKBKB	associated_with	gene	0.60
CASP8	associated_with	gene	0.60
AKT1	treats	gene	0.60
STAT3	treats	gene	0.60
MMP9	treats	gene	0.60
MYC	associated_with	gene	0.60
TP53	biomarker_for	gene	0.60
PTEN	biomarker_for	gene	0.60
PI3K	biomarker_for	gene	0.60
SIRT6	interacts_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

No debates reference this entity

Related Research

Hypotheses and analyses mentioning RANK in their description or question text

No additional research found