Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HMGCR, LDLR, APOE regulatory regions: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| HTT, DMPK, repeat-containing transcripts | debate_co_mention | gene | 0.45 |
| NURR1, PITX3, neuronal identity transcription factors | debate_co_mention | gene | 0.45 |
| PGC1A, SIRT1, FOXO3, mitochondrial biogenesis genes | debate_co_mention | gene | 0.45 |
| RANK | debate_co_mention | gene | 0.45 |
| benchmark_ot_ad_answer_key:HMGCR, LDLR, APOE REGULATORY REGIONS | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| BDNF | debate_co_mention | gene | 0.45 |
| BDNF, CREB1, synaptic plasticity genes | debate_co_mention | gene | 0.45 |
| Cell-type-specific essential genes | debate_co_mention | gene | 0.45 |
| Disease-causing mutations with integrated reporters | debate_co_mention | gene | 0.45 |
| benchmark_ot_ad_answer_key:HMGCR, LDLR, APOE REGULATORY REGIONS | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Cholesterol-CRISPR Convergence Therapy for Neurodegeneration | 0.622 | neurodegeneration | CRISPR-based therapeutic approaches for |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Cholinergic neurodegeneration and cholesterol metabolism dysregulation by consti [PMID:37900943] | ["Comaposada-Bar\u00f3 R", "Benito-Mart\ | Frontiers in molecular neurosc | 2023 | 0 |
| Delivery challenges for CRISPR therapeutics to the central nervous system [PMID:35173339] | Doudna JA, Sternberg SH | Nature Biotechnology | 2022 | 0 |
| Immune responses to AAV-delivered CRISPR components limit therapeutic durability [PMID:34469734] | Charlesworth CT, Deshpande PS, Dever DP, | Nature Medicine | 2021 | 0 |
| CRISPR-Cas9 off-target effects in the brain: safety concerns for therapeutic gen [PMID:33199879] | Trevino AE, Zhang F | Nature Methods | 2020 | 0 |
| Quinovic Acid Impedes Cholesterol Dyshomeostasis, Oxidative Stress, and Neurodeg [PMID:33274012] | ["Saeed K", "Shah S", "Ullah R", "Alam S | Oxidative medicine and cellula | 2020 | 0 |
| The beneficial effects of HMG-CoA reductase inhibitors in the processes of neuro [PMID:28578514] | ["Saeedi Saravi S", "Saeedi Saravi S", " | Metabolic brain disease | 2017 | 0 |
| 25-Hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain [PMID:39181516] | Unknown | 0 | ||
| HMGCR genetic variability in Parkinson's disease in a Spanish cohort: associatio [PMID:41037108] | Unknown | 0 |
Multi-agent debates referencing this entity
No debates reference this entity