Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about HONOKIOL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | HONOKIOL |
Knowledge base pages for this entity
graph TD
HONOKIOL["HONOKIOL"]
HONOKIOL -->|"activates"| SIRT3["SIRT3"]
HONOKIOL -->|"inhibits"| Oxidative_Stress["Oxidative Stress"]
HONOKIOL -->|"treats"| Alzheimer_s_disease["Alzheimer's disease"]
HONOKIOL -->|"treats"| Alzheimer_s_Disease["Alzheimer's Disease"]
HONOKIOL -->|"inhibits"| A_1_42_Plaque_Deposition["Abeta1-42 Plaque Deposition"]
HONOKIOL -->|"treats"| Amyotrophic_Lateral_Sclerosis["Amyotrophic Lateral Sclerosis"]
HONOKIOL -.protects against.-> Mitochondrial_Dysfunction["Mitochondrial Dysfunction"]
HONOKIOL -->|"inhibits"| A__aggregation["Abeta aggregation"]| Target | Relation | Type | Str |
|---|---|---|---|
| Oxidative Stress | associated_with | process | 0.95 |
| Mitochondrial Dysfunction | associated_with | process | 0.95 |
| Alzheimer'S Disease | treats | disease | 0.95 |
| SIRT3 | activates | protein | 0.90 |
| Hippocampal Neuron Survival | promotes | phenotype | 0.90 |
| Oxidative Stress | inhibits | process | 0.90 |
| Alzheimer's disease | treats | disease | 0.90 |
| OXIDATIVE STRESS | associated_with | process | 0.90 |
| MITOCHONDRIA | associated_with | cell_type | 0.90 |
| NEURODEGENERATION | protects_against | process | 0.90 |
| Mitochondrial Function | associated_with | process | 0.90 |
| Aβ1-42 Plaque Deposition | inhibits | phenotype | 0.85 |
| Cognitive Function | associated_with | phenotype | 0.85 |
| Hippocampal Neuron Survival | associated_with | phenotype | 0.85 |
| Aβ1-42 Plaque Deposition | associated_with | biomarker | 0.85 |
| Aβ aggregation | inhibits | process | 0.85 |
| NRF2-ARE Pathway | activates | pathway | 0.85 |
| Alzheimer's Disease | treats | disease | 0.85 |
| Amyotrophic Lateral Sclerosis | treats | disease | 0.85 |
| Mitochondrial Dysfunction | protects_against | process | 0.85 |
| ALS | treats | disease | 0.85 |
| Motor Neurons | protects_against | cell_type | 0.80 |
| Neuronal Apoptosis | inhibits | process | 0.80 |
| Motor Neuron | protects_against | cell_type | 0.80 |
| Mitochondrial Dynamics | modulates | process | 0.80 |
| ALZHEIMER'S DISEASE | treats | disease | 0.80 |
| PARKINSON'S DISEASE | treats | disease | 0.80 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||