disease

Hyperthyroidism

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about Hyperthyroidism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

14Connections
0Hypotheses
0Analyses
8Outgoing
6Incoming

No summary available yet. View on Wiki →

Disease Info
CategoryGenetic/Complex
Associated GenesAKT1, BACE1, CDK5, RPS6KA3
KG Connections14 knowledge graph edges
DatabasesOMIMOrphanetClinicalTrialsPubMed

Wiki Pages (12)

Knowledge base pages for this entity

Thyroid Hormone Signaling Pathway in Neurodegeneration

mechanism · 3884 words

GSK3B Gene - Glycogen Synthase Kinase 3 Beta

gene · 3026 words

Wernicke-Korsakoff Syndrome

disease · 2625 words

Thyroid Follicular Cells

cell · 2071 words

Cdk5 (Cyclin-Dependent Kinase 5)

protein · 1722 words

Pathway Diagram

graph TD
    Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| Neurodegeneration_Related_Gene["Neurodegeneration-Related Gene Expression"]
    style Neurodegeneration_Related_Gene fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    Hyperthyroidism["Hyperthyroidism"] -->|"risk factor for"| Neurodegeneration["Neurodegeneration"]
    style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| BACE1["BACE1"]
    style BACE1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| CDK5["CDK5"]
    style CDK5 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| AKT1["AKT1"]
    style AKT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| GSK3B["GSK3B"]
    style GSK3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    Hyperthyroidism["Hyperthyroidism"] -->|"risk factor for"| Neurodegenerative_Disease["Neurodegenerative Disease"]
    style Neurodegenerative_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
    L_Thyroxine["L-Thyroxine"] -->|"causes"| Hyperthyroidism["Hyperthyroidism"]
    style L_Thyroxine fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    AKT1_1["AKT1"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
    style AKT1_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    BACE1_2["BACE1"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
    style BACE1_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    CDK5_3["CDK5"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
    style CDK5_3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    RPS6KA3["RPS6KA3"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
    style RPS6KA3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style Hyperthyroidism fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (8)

TargetRelationTypeStr
Neurodegeneration-Related Gene Expressionupregulatesprocess0.95
Neurodegenerationrisk_factor_fordisease0.90
BACE1upregulatesgene0.85
CDK5upregulatesgene0.85
AKT1upregulatesgene0.85

Incoming (6)

SourceRelationTypeStr
L-Thyroxinecausesdrug0.90
AKT1associated_withgene0.85
BACE1associated_withgene0.85
CDK5associated_withgene0.85
RPS6KA3associated_withgene0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found