Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Hyperthyroidism: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Category | Genetic/Complex |
| Associated Genes | AKT1, BACE1, CDK5, RPS6KA3 |
| KG Connections | 14 knowledge graph edges |
| Databases | OMIMOrphanetClinicalTrialsPubMed |
Knowledge base pages for this entity
graph TD
Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| Neurodegeneration_Related_Gene["Neurodegeneration-Related Gene Expression"]
style Neurodegeneration_Related_Gene fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
Hyperthyroidism["Hyperthyroidism"] -->|"risk factor for"| Neurodegeneration["Neurodegeneration"]
style Neurodegeneration fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| BACE1["BACE1"]
style BACE1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| CDK5["CDK5"]
style CDK5 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| AKT1["AKT1"]
style AKT1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Hyperthyroidism["Hyperthyroidism"] -->|"regulates"| GSK3B["GSK3B"]
style GSK3B fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
Hyperthyroidism["Hyperthyroidism"] -->|"risk factor for"| Neurodegenerative_Disease["Neurodegenerative Disease"]
style Neurodegenerative_Disease fill:#1a2a3a,stroke:#ef5350,stroke-width:1px,color:#fff
L_Thyroxine["L-Thyroxine"] -->|"causes"| Hyperthyroidism["Hyperthyroidism"]
style L_Thyroxine fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
AKT1_1["AKT1"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
style AKT1_1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
BACE1_2["BACE1"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
style BACE1_2 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
CDK5_3["CDK5"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
style CDK5_3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
RPS6KA3["RPS6KA3"] -->|"associated"| Hyperthyroidism["Hyperthyroidism"]
style RPS6KA3 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
style Hyperthyroidism fill:#ef5350,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold| Target | Relation | Type | Str |
|---|---|---|---|
| Neurodegeneration-Related Gene Expression | upregulates | process | 0.95 |
| Neurodegeneration | risk_factor_for | disease | 0.90 |
| BACE1 | upregulates | gene | 0.85 |
| CDK5 | upregulates | gene | 0.85 |
| AKT1 | upregulates | gene | 0.85 |
| GSK3B | downregulates | gene | 0.85 |
| Neurodegenerative Disease | risk_factor_for | disease | 0.80 |
| Metaplasticity | modulates | process | 0.75 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||