GSK3B

Understanding Entity Pages

This page aggregates everything SciDEX knows about GSK3B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

Summary

Glycogen Synthase Kinase 3 Beta (GSK3B) is a serine/threonine kinase central to tau phosphorylation, Wnt signaling, glycogen metabolism, and neuroinflammation. GSK3B is the primary kinase responsible for hyperphosphorylation of tau at disease-relevant epitopes (AT8, PHF-1), driving neurofibrillary tangle formation in Alzheimer's disease. GSK3B also promotes amyloid-beta production by enhancing gamma-secretase activity and BACE1 expression. In the Wnt pathway, GSK3B phosphorylates beta-catenin for degradation; Wnt signaling inhibits GSK3B, promoting cell survival. Lithium, a GSK3B inhibitor, reduces tau phosphorylation and has shown neuroprotective effects in preclinical models. Selective GSK3B inhibitors are in clinical development for AD and tauopathies.

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graph TD
    GSK3B["GSK3B"] -->|"activates"| apoptosis["apoptosis"]
    GSK3B["GSK3B"] -->|"associated"| Cancer["Cancer"]
    GSK3B["GSK3B"] -->|"associated"| Carcinoma["Carcinoma"]
    GSK3B["GSK3B"] -->|"activates"| Tumor["Tumor"]
    GSK3B["GSK3B"] -->|"activates"| Als["Als"]
    GSK3B["GSK3B"] -->|"activates"| Alzheimer["Alzheimer"]
    oxidative_stress["oxidative stress"] -->|"contributes to"| GSK3B["GSK3B"]
    PRKCD["PRKCD"] -->|"associated"| GSK3B["GSK3B"]
    TCF4["TCF4"] -->|"associated"| GSK3B["GSK3B"]
    MYC["MYC"] -->|"associated"| GSK3B["GSK3B"]
    style GSK3B fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0