protein

IL6STPROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about IL6STPROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

IL6 Signal Transducer (gp130) is encoded by the IL6ST gene on chromosome 5q11.2.

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🔬 Protein Info

Gene Symbol	IL6STPROTEIN
Chromosome	5q11.2.
Function	is a critical mediator of neuroinflammation and neurotrophic signaling in the central nervous system.
Molecular Weight	130 kDa
Amino Acids	917 aa
GeneCards	IL6STPROTEIN
Human Protein Atlas	IL6STPROTEIN
YXXQ motifs	Multiple
SHP2 binding	Y759
Agent	Status
IL-6	Experimental
CNTF	Clinical trials
Hyper-IL-6	Preclinical
Tocilizumab	Approved (RA)
Sarilumab	Approved
Associated Diseases	neurodegeneration
Interactions	JAK2, MYC, GATA1, NR3C1, CREBBP, LRP1
KG Connections	64 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

IL6 Signal Transducer (gp130/IL6ST) Protein

protein · 608 words

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Pathway Diagram

graph TD
    IL6STPROTEIN["IL6STPROTEIN"]
    neurodegeneration["neurodegeneration"]
    IL6STPROTEIN -->|"implicated_in"| neurodegeneration
    style IL6STPROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found