gene

CREBBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREBBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

492Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

CREBBP is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 321 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CREBBP
Full Name	CREB Binding Protein
Chromosome	16p13.3
Protein Type	Transcription Factor
Function	is a transcriptional coactivator that acetylates histones and transcription factors
Primary Expression	most neuronal subtypes including pyramidal cells, interneurons - Glia: Present in astrocytes and [microglia](/entities/mic
Molecular Weight	265 kDa
Pathways	NF-κB
UniProt ID	Q92793 (CREBBP)
NCBI Gene ID	1387
Ensembl ID	ENSG00000105383
OMIM	600140
GeneCards	CREBBP
Human Protein Atlas	CREBBP
Associated Diseases	ALS, Cancer, Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	IL6ST, CREB1, KMT2D, BCL2, LRP1, CALCOCO2
KG Connections	491 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CREBBP — AlphaFold Q92793 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    CREBBP["CREBBP"] -->|"Regulates"| histone_H2B_acetylation["histone H2B acetylation"]
    CREBBP["CREBBP"] -->|"Associated With"| Tumor["Tumor"]
    CREBBP["CREBBP"] -->|"Associated With"| Parkinson["Parkinson"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Cancer["Cancer"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Ms["Ms"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Glioblastoma["Glioblastoma"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Fibrosis["Fibrosis"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Hepatitis["Hepatitis"]
    OPTN["OPTN"] -->|"Associated With"| CREBBP["CREBBP"]
    ULK1["ULK1"] -->|"Associated With"| CREBBP["CREBBP"]
    CALCOCO2["CALCOCO2"] -->|"Associated With"| CREBBP["CREBBP"]
    HSPA8["HSPA8"] -->|"Associated With"| CREBBP["CREBBP"]
    STX17["STX17"] -->|"Associated With"| CREBBP["CREBBP"]
    style CREBBP fill:#8d4900,color:#e0e0e0
    style histone_H2B_acetylation fill:#1b5e20,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style HSPA8 fill:#8d4900,color:#e0e0e0
    style STX17 fill:#8d4900,color:#e0e0e0

Outgoing (292)

Target	Relation	Type	Str
Reactive Oxygen Species	regulates	process	0.85
Parkinson's Disease	regulates	disease	0.80
Cancer	therapeutic_target	disease	0.75
histone H2B acetylation	regulates	process	0.70
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Ms	therapeutic_target	disease	0.65
Parkinson	therapeutic_target	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Als	regulates	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Ms	inhibits	disease	0.65
Migraine	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Ms	expressed_in	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	interacts_with	disease	0.65
Cancer	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	contributes_to	disease	0.65
Schizophrenia	activates	disease	0.65
Cancer	inhibits	disease	0.65
Parkinson	regulates	disease	0.65
Cancer	regulates	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Liver Cancer	therapeutic_target	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Lymphoma	interacts_with	disease	0.65
Leukemia	inhibits	disease	0.65
ALS	regulates	disease	0.65
NBR1	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
EP300	associated_with	gene	0.60

Incoming (200)

Source	Relation	Type	Str
BECN1	regulates	gene	0.65
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
KAT8	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60
RB1	associated_with	gene	0.60
KAT2B	associated_with	gene	0.60
KAT5	associated_with	gene	0.60
WIPI2	associated_with	gene	0.60
BECN1	associated_with	gene	0.60
HDAC6	associated_with	gene	0.60
SOD2	therapeutic_target	gene	0.60
PPARGC1A	therapeutic_target	gene	0.60
SIRT3	therapeutic_target	gene	0.60
PRKAA1	therapeutic_target	gene	0.60
PIK3C3	associated_with	gene	0.60
TFEB	associated_with	gene	0.60
EP300	associated_with	gene	0.60
MTOR	associated_with	gene	0.60
NDP52	associated_with	gene	0.60
P62	associated_with	gene	0.60
LAMP2A	associated_with	gene	0.60
KAT2A	associated_with	gene	0.60
FIP200	associated_with	gene	0.60
HSP70	associated_with	gene	0.60
GAPDH	associated_with	gene	0.60
VAMP8	associated_with	gene	0.60
TP53	associated_with	gene	0.60
RUBCN	associated_with	gene	0.60
FOXO1	therapeutic_target	gene	0.60
RB1	therapeutic_target	gene	0.60
EGFR	therapeutic_target	gene	0.60
TP53	therapeutic_target	gene	0.60
GBM	associated_with	gene	0.60
FGF20	therapeutic_target	gene	0.60
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

CREBBP

Understanding Entity Pages

Summary

Wiki Pages (21)

CREBBP Gene

NRF2 Oxidative Stress Pathway

Kabuki Syndrome

Epigenetic Dysregulation in Neurodegeneration

KMT2E Gene (Lysine Methyltransferase 2E)

SMARCA2 (BRM)

PDLIM7 Epigenetic Activation in Parkinson's Disease

ESRRG Gene

KAT6A Gene

TRPM3 Gene - Transient Receptor Potential Channel

HDAC2 Protein — Histone Deacetylase 2

KAT2A (Lysine Acetyltransferase 2A)

kat6b

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

NSD1 (Nuclear Receptor Binding SET Domain Protein 1)

cAMP Signaling Pathway in Neurodegeneration

BRD4 (Bromodomain-Containing Protein 4)

BRD3 (Bromodomain-Containing Protein 3)

Ataxin-8 Protein