gene

CREBBP

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about CREBBP: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

486Connections

1Hypotheses

1Analyses

50Outgoing

50Incoming

0Experiments

3Debates

Summary

CREBBP is a gene implicated in neurodegeneration research. Key relationships include: associated with, therapeutic target, regulates. Associated with Als, Amyotrophic Lateral Sclerosis, Cancer. Connected to 321 entities in the SciDEX knowledge graph.

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🧬 Gene Info

Gene Symbol	CREBBP
Full Name	CREB Binding Protein
Chromosome	16p13.3
Protein Type	Transcription Factor
Function	is a transcriptional coactivator that acetylates histones and transcription factors
Primary Expression	most neuronal subtypes including pyramidal cells, interneurons - Glia: Present in astrocytes and [microglia](/entities/mic
Molecular Weight	265 kDa
Pathways	NF-κB
UniProt ID	Q92793 (CREBBP)
NCBI Gene ID	1387
Ensembl ID	ENSG00000105383
OMIM	600140
GeneCards	CREBBP
Human Protein Atlas	CREBBP
Associated Diseases	ALS, Cancer, Parkinson, Tumor
Known Drugs/Compounds	rapamycin
Interactions	ACAT1, AMPK, APOPTOSIS, ATG, BCL2, CALCOCO2
SciDEX Hypotheses	Synaptic Chromatin Compartment Rejuvenation
KG Connections	485 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: CREBBP — AlphaFold Q92793 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (2)

Knowledge base pages for this entity

Canonical Page

CREBBP Gene

gene · 680 words

→

CREBBP Protein

protein · 774 words

→

Pathway Diagram

graph TD
    CREBBP["CREBBP"] -->|"Regulates"| histone_H2B_acetylation["histone H2B acetylation"]
    CREBBP["CREBBP"] -->|"Associated With"| Tumor["Tumor"]
    CREBBP["CREBBP"] -->|"Associated With"| Parkinson["Parkinson"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Cancer["Cancer"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Ms["Ms"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Glioblastoma["Glioblastoma"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Fibrosis["Fibrosis"]
    CREBBP["CREBBP"] -->|"Therapeutic Target"| Hepatitis["Hepatitis"]
    OPTN["OPTN"] -->|"Associated With"| CREBBP["CREBBP"]
    ULK1["ULK1"] -->|"Associated With"| CREBBP["CREBBP"]
    CALCOCO2["CALCOCO2"] -->|"Associated With"| CREBBP["CREBBP"]
    HSPA8["HSPA8"] -->|"Associated With"| CREBBP["CREBBP"]
    STX17["STX17"] -->|"Associated With"| CREBBP["CREBBP"]
    style CREBBP fill:#8d4900,color:#e0e0e0
    style histone_H2B_acetylation fill:#1b5e20,color:#e0e0e0
    style Tumor fill:#b71c1c,color:#e0e0e0
    style Parkinson fill:#b71c1c,color:#e0e0e0
    style Cancer fill:#b71c1c,color:#e0e0e0
    style Ms fill:#b71c1c,color:#e0e0e0
    style Glioblastoma fill:#b71c1c,color:#e0e0e0
    style Fibrosis fill:#b71c1c,color:#e0e0e0
    style Hepatitis fill:#b71c1c,color:#e0e0e0
    style OPTN fill:#8d4900,color:#e0e0e0
    style ULK1 fill:#8d4900,color:#e0e0e0
    style CALCOCO2 fill:#8d4900,color:#e0e0e0
    style HSPA8 fill:#8d4900,color:#e0e0e0
    style STX17 fill:#8d4900,color:#e0e0e0

Outgoing (290)

Target	Relation	Type	Str
Reactive Oxygen Species	regulates	process	0.85
acetylation	promotes	process	0.85
Parkinson's Disease	regulates	disease	0.80
Cancer	therapeutic_target	disease	0.75
synaptic plasticity	regulates	phenotype	0.70
histone H2B acetylation	regulates	process	0.70
Liver Cancer	therapeutic_target	disease	0.65
Lymphoma	interacts_with	disease	0.65
Colorectal Cancer	therapeutic_target	disease	0.65
Cancer	inhibits	disease	0.65
Gastric Cancer	therapeutic_target	disease	0.65
Hepatocellular Carcinoma	therapeutic_target	disease	0.65
Leukemia	inhibits	disease	0.65
Lung Cancer	therapeutic_target	disease	0.65
Ms	expressed_in	disease	0.65
Parkinson	regulates	disease	0.65
Inflammation	therapeutic_target	disease	0.65
Hepatitis	therapeutic_target	disease	0.65
Ms	inhibits	disease	0.65
Als	expressed_in	disease	0.65
Cancer	interacts_with	disease	0.65
Schizophrenia	activates	disease	0.65
Pulmonary Fibrosis	therapeutic_target	disease	0.65
Pancreatic Cancer	therapeutic_target	disease	0.65
Prostate Cancer	therapeutic_target	disease	0.65
Infection	therapeutic_target	disease	0.65
Cancer	associated_with	disease	0.65
Parkinson	therapeutic_target	disease	0.65
ALS	regulates	disease	0.65
Tumor	associated_with	disease	0.65
Parkinson	associated_with	disease	0.65
Glioblastoma	therapeutic_target	disease	0.65
Als	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Tumor	therapeutic_target	disease	0.65
Fibrosis	therapeutic_target	disease	0.65
Carcinoma	therapeutic_target	disease	0.65
Als	therapeutic_target	disease	0.65
Ms	regulates	disease	0.65
Amyotrophic Lateral Sclerosis	regulates	disease	0.65
Cancer	regulates	disease	0.65
Migraine	inhibits	disease	0.65
Cancer	expressed_in	disease	0.65
Carcinoma	interacts_with	disease	0.65
Tumor	interacts_with	disease	0.65
Ms	contributes_to	disease	0.65
ULK1	co_discussed	gene	0.60
TP53	co_discussed	gene	0.60
LC3	associated_with	gene	0.60
TFEB	co_discussed	gene	0.60

Incoming (196)

Source	Relation	Type	Str
BECN1	regulates	gene	0.65
BRG1	regulates	gene	0.60
NRCAM	therapeutic_target	gene	0.60
NOTCH2	therapeutic_target	gene	0.60
EP300	regulates	gene	0.60
CTNNB1	regulates	gene	0.60
NEUROD1	therapeutic_target	gene	0.60
MYC	therapeutic_target	gene	0.60
VEGFA	therapeutic_target	gene	0.60
ABCB1	therapeutic_target	gene	0.60
FOXM1	regulates	gene	0.60
LEF1	therapeutic_target	gene	0.60
FGF20	therapeutic_target	gene	0.60
TERT	therapeutic_target	gene	0.60
FZD7	therapeutic_target	gene	0.60
JAG1	therapeutic_target	gene	0.60
MITF	therapeutic_target	gene	0.60
TRPA1	inhibits	gene	0.60
SRC	inhibits	gene	0.60
SCN8A	regulates	gene	0.60
AKT1	regulates	gene	0.60
TRPM3	regulates	gene	0.60
PRKAA1	regulates	gene	0.60
BECN1	activates	entity	0.60
CALCOCO2	activates	entity	0.60
SMARCA4	regulates	gene	0.60
MAP1LC3	associated_with	gene	0.60
GENES	therapeutic_target	gene	0.60
MOTOR NEURONS	regulates	gene	0.60
AMYOTROPHIC LATERAL SCLEROSIS	regulates	gene	0.60
ALS	regulates	gene	0.60
MIRNAS	expressed_in	gene	0.60
CANCER	expressed_in	gene	0.60
MICRORNAS	expressed_in	gene	0.60
CANCER	inhibits	gene	0.60
OXIDATIVE STRESS	regulates	gene	0.60
CREB	interacts_with	gene	0.60
OXIDATIVE STRESS	associated_with	gene	0.60
COL4A1	interacts_with	gene	0.60
KAT8	associated_with	gene	0.60
OPTN	associated_with	gene	0.60
ULK1	associated_with	gene	0.60
CALCOCO2	associated_with	gene	0.60
HSPA8	associated_with	gene	0.60
STX17	associated_with	gene	0.60
SQSTM1	associated_with	gene	0.60
RB1CC1	associated_with	gene	0.60
SIRT1	associated_with	gene	0.60
LC3	associated_with	gene	0.60
SNAP29	associated_with	gene	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Synaptic Chromatin Compartment Rejuvenation	0.000	-	Epigenetic reprogramming in aging neuron

Mentioning Analyses (1)

Scientific analyses that reference this entity

Epigenetic reprogramming in aging neurons

neurodegeneration | 2026-04-04 | 16 hypotheses Top: 0.779

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (3)

Multi-agent debates referencing this entity

Related Research

Hypotheses and analyses mentioning CREBBP in their description or question text

No additional research found

CREBBP

Understanding Entity Pages

Summary

Wiki Pages (2)

CREBBP Gene

CREBBP Protein

Pathway Diagram

Outgoing (290)

Incoming (196)

Targeting Hypotheses (1)

Mentioning Analyses (1)

Epigenetic reprogramming in aging neurons

Experiments (0)

Related Papers (0)

Debates (3)

Debate: Chromatin Remodeling-Mediated Nutrient Sensing Restoration

Hypothesis debate: Nutrient-Sensing Epigenetic Circuit Reactivation

Epigenetic reprogramming in aging neurons

Related Research