Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Irinotecan: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| TOP1 | targets | gene | 0.95 |
| Topoisomerase 1 | inhibits | enzyme | 0.95 |
| Cancer | treats | disease | 0.95 |
| Osteosarcoma Cell Death | treats | phenotype | 0.90 |
| Osteosarcoma Cell Death | promotes | phenotype | 0.90 |
| Hnrnpa2B1 | binds | protein | 0.90 |
| Hnrnpa2B1 | interacts_with | protein | 0.90 |
| HNRNPA2B1 | interacts_with | protein | 0.90 |
| Paclitaxel | interacts_with | drug | 0.88 |
| Glial Cells | targets | cell_type | 0.85 |
| Ad-Related Gene Networks | modulates | pathway | 0.85 |
| Cancer progression | suppresses | process | 0.85 |
| Rna Recognition Domain | binds | protein | 0.85 |
| PSME2 | activates | gene | 0.85 |
| Hnrnpa2B1 | modulates | protein | 0.80 |
| Camptothecin | associated_with | drug | 0.80 |
| Anticancer Activity | mediates | mechanism | 0.80 |
| Alzheimer'S Disease | treats | disease | 0.80 |
| Hnrnpa2B1 | inhibits | protein | 0.75 |
| HNRNPA2B1 | inhibits | protein | 0.75 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Paclitaxel | interacts_with | drug | 0.88 |
| 17-Dmag | associated_with | drug | 0.85 |
| 17-DMAG | associated_with | drug | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||