concept

PACLITAXEL

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PACLITAXEL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

46Connections

0Hypotheses

0Analyses

15Outgoing

22Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	PACLITAXEL
Key Genes/Proteins	HNRNPA1, AKT
Related Diseases	ROS, NEUROPATHY, PANCREATIC CANCER, CANCER, AUTOPHAGY

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    PACLITAXEL["PACLITAXEL"]
    PACLITAXEL -->|"causes"| Chemotherapy_Induced_Periphera["Chemotherapy-Induced Peripheral Neuropathy"]
    PACLITAXEL -->|"interacts"| Irinotecan["Irinotecan"]
    PACLITAXEL -->|"upregulates"| ATAD3A["ATAD3A"]
    PACLITAXEL -->|"treats"| Nasopharyngeal_Carcinoma["Nasopharyngeal Carcinoma"]
    PACLITAXEL -->|"causes"| ROS["ROS"]
    Irinotecan -->|"interacts"| PACLITAXEL
    CISPLATIN["CISPLATIN"] -->|"activates"| PACLITAXEL
    CANCER["CANCER"] -->|"activates"| PACLITAXEL
    NEUROPATHY["NEUROPATHY"] -->|"activates"| PACLITAXEL
    AUTOPHAGY["AUTOPHAGY"] -->|"inhibits"| PACLITAXEL
    CREB["CREB"] -->|"inhibits"| PACLITAXEL

Outgoing (23)

Target	Relation	Type	Str
ROS	causes	phenotype	0.65
HNRNPA1	activates	gene	0.65
NEUROPATHY	causes	disease	0.65
AKT	associated_with	gene	0.50
CISPLATIN	associated_with	drug	0.45
CANCER	associated_with	disease	0.45
ROS	associated_with	phenotype	0.45
BORTEZOMIB	associated_with	drug	0.45
NEUROPATHY	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CREB	associated_with	gene	0.45
DOCETAXEL	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
HNRNPA1	associated_with	gene	0.45
ROS	activates	protein	0.35

Incoming (23)

Source	Relation	Type	Str
AKT	synergizes_with	gene	0.65
AKT	inhibits	gene	0.65
IRINOTECAN	synergizes_with	drug	0.60
CISPLATIN	activates	drug	0.50
PANCREATIC CANCER	associated_with	disease	0.50
CARBOPLATIN	associated_with	drug	0.45
OXALIPLATIN	associated_with	drug	0.45
VINCRISTINE	associated_with	drug	0.45
EMT	associated_with	phenotype	0.45
CANCER	associated_with	disease	0.45
CISPLATIN	associated_with	drug	0.45
BORTEZOMIB	associated_with	drug	0.45
NEUROPATHY	associated_with	disease	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CREB	associated_with	gene	0.45
5-FLUOROURACIL	associated_with	drug	0.45
DOCETAXEL	associated_with	drug	0.45
CANCER	activates	disease	0.35
NEUROPATHY	activates	disease	0.35
AUTOPHAGY	inhibits	process	0.35
CREB	inhibits	gene	0.35
CISPLATIN	protects_against	drug	0.35

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PACLITAXEL

Understanding Entity Pages

Wiki Pages (20)

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