Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TOP1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Target | Relation | Type | Str |
|---|---|---|---|
| DNA Double-Strand Breaks | causes | process | 0.95 |
| DNA Double-Strand Breaks | mediates | process | 0.95 |
| Dna Double-Strand Breaks | causes | process | 0.95 |
| DNA Double-Strand Breaks | contributes_to | process | 0.92 |
| R-Loops | interacts_with | mechanism | 0.85 |
| Transcription | modulates | process | 0.80 |
| benchmark_ot_ad_answer_key:TOP1 | data_in | dataset_row | 0.00 |
| Source | Relation | Type | Str |
|---|---|---|---|
| Irinotecan | targets | drug | 0.95 |
| TDP1 | degrades | protein | 0.90 |
| XRCC1 | interacts_with | protein | 0.80 |
| PNKP | involved_in | protein | 0.80 |
| XRCC1 | involved_in | protein | 0.80 |
| benchmark_ot_ad_answer_key:TOP1 | data_in | dataset_row | 0.00 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||