Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KCNA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | KCNA3 |
| Full Name | Potassium Voltage-Gated Channel Subfamily A Member 3 |
| Aliases | Potassium Voltage-Gated Channel |
| Chromosome | 1p13.3 |
| Function | KCNA3 encodes the Kv1.3 potassium channel, a member of the voltage-gated potassium channel family. |
| Primary Expression | immune cells and neurons, where it plays crucial roles in regulating membrane potential, neuronal excitability, and immune cell f |
| Molecular Weight | 58 kDa |
| UniProt ID | P22001 |
| NCBI Gene ID | 3777 |
| Ensembl ID | ENSG00000166012 |
| GeneCards | KCNA3 |
| Human Protein Atlas | KCNA3 |
| Associated Diseases | Parkinson'S Disease |
| KG Connections | 7 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
KCNA3(["KCNA3"])
style KCNA3 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
Neuroinflammation["Neuroinflammation"]
Neurodegeneration["Neurodegeneration"]
Parkinson_S_Disease(["Parkinson'S Disease"])
Microglia["/"Microglia"/"]
SNCA["SNCA"]
Microglial_Activation(["Microglial Activation"])
FYN["FYN"]
neurodegeneration["neurodegeneration"]
KCNA3 -->|"modulates"| Neuroinflammation
KCNA3 -->|"modulates"| Neurodegeneration
KCNA3 -->|"associated_with"| Parkinson_S_Disease
KCNA3 -->|"expressed_in"| Microglia
SNCA -->|"upregulates"| KCNA3
KCNA3 -->|"contributes_to"| Microglial_Activation
FYN -->|"modulates"| KCNA3
KCNA3 -->|"implicated_in"| neurodegeneration
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
class Neuroinflammation protein
class Neurodegeneration disease
class Parkinson_S_Disease protein
class Microglia mechanism
class SNCA gene
class Microglial_Activation protein
class FYN gene
class neurodegeneration disease| Target | Relation | Type | Str |
|---|---|---|---|
| Neuroinflammation | modulates | process | 0.95 |
| Neurodegeneration | modulates | process | 0.95 |
| Parkinson'S Disease | associated_with | disease | 0.90 |
| Microglia | expressed_in | cell_type | 0.90 |
| Microglial Activation | contributes_to | process | 0.85 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||