protein

KCNA3

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KCNA3: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

7Connections
0Hypotheses
0Analyses
5Outgoing
2Incoming
0Experiments

Summary

Page for KCNA3 Protein

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🔬 Protein Info
Gene SymbolKCNA3
Full NamePotassium Voltage-Gated Channel Subfamily A Member 3
AliasesPotassium Voltage-Gated Channel
Chromosome1p13.3
FunctionKCNA3 encodes the Kv1.3 potassium channel, a member of the voltage-gated potassium channel family.
Primary Expressionimmune cells and neurons, where it plays crucial roles in regulating membrane potential, neuronal excitability, and immune cell f
Molecular Weight58 kDa
UniProt IDP22001
NCBI Gene ID3777
Ensembl IDENSG00000166012
GeneCardsKCNA3
Human Protein AtlasKCNA3
Associated DiseasesParkinson'S Disease
KG Connections7 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: KCNA3 — AlphaFold P22001 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (7)

Knowledge base pages for this entity

Canonical Page

KCNA3 — Potassium Voltage-Gated Channel

gene · 656 words

KCNAB3 — Potassium Voltage-Gated Channel Subfamily A Member Beta 3

gene · 3027 words

KCNA7 Gene - Potassium Voltage-Gated Channel Subfamily A Member 7

gene · 2235 words

KCNA10 Gene

gene · 1905 words

KCNA3 Protein

protein · 626 words

Proteins

index · 296 words

Pathway Diagram

graph TD
    KCNA3(["KCNA3"])
    style KCNA3 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff
    Neuroinflammation["Neuroinflammation"]
    Neurodegeneration["Neurodegeneration"]
    Parkinson_S_Disease(["Parkinson'S Disease"])
    Microglia["/"Microglia"/"]
    SNCA["SNCA"]
    Microglial_Activation(["Microglial Activation"])
    FYN["FYN"]
    neurodegeneration["neurodegeneration"]

    KCNA3 -->|"modulates"| Neuroinflammation
    KCNA3 -->|"modulates"| Neurodegeneration
    KCNA3 -->|"associated_with"| Parkinson_S_Disease
    KCNA3 -->|"expressed_in"| Microglia
    SNCA -->|"upregulates"| KCNA3
    KCNA3 -->|"contributes_to"| Microglial_Activation
    FYN -->|"modulates"| KCNA3
    KCNA3 -->|"implicated_in"| neurodegeneration

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    classDef drug fill:#1a2a2a,stroke:#80cbc4,color:#e0e0e0
    class Neuroinflammation protein
    class Neurodegeneration disease
    class Parkinson_S_Disease protein
    class Microglia mechanism
    class SNCA gene
    class Microglial_Activation protein
    class FYN gene
    class neurodegeneration disease

Outgoing (5)

TargetRelationTypeStr
Neuroinflammationmodulatesprocess0.95
Neurodegenerationmodulatesprocess0.95
Parkinson'S Diseaseassociated_withdisease0.90
Microgliaexpressed_incell_type0.90
Microglial Activationcontributes_toprocess0.85

Incoming (2)

SourceRelationTypeStr
SNCAupregulatesgene0.90
FYNmodulatesgene0.85

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

ExperimentTypeDiseaseScoreFeasibilityModelStatusEst. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found