gene

FYN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about FYN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

427Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

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🧬 Gene Info

Gene Symbol	FYN
Full Name	FYN Proto-Oncogene, Src Family Tyrosine Kinase
Aliases	Fyn Tyrosine Kinase
Chromosome	6q21.
Protein Type	Receptor
Function	encodes a member of the Src family of non-receptor tyrosine kinases (SFKs).
Primary Expression	T-cells, NK cells, and other immune cells
Molecular Weight	~60 kDa
Amino Acids	537 aa
Pathways	Akt, Apoptosis, Dendritic Spine, Endocytosis, Pi3K
UniProt ID	P39687
NCBI Gene ID	2534
Ensembl ID	ENSG00000110881
OMIM	137025
GeneCards	FYN
Human Protein Atlas	FYN
Associated Diseases	ALS, Aging, Alzheimer, Alzheimer's disease, Autism
Interactions	SRC, KEAP1, CUL3, NRF2, BACH1, LCK
KG Connections	426 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: FYN — AlphaFold P39687 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    FYN["FYN"]
    FYN -->|"activates"| STAT3["STAT3"]
    FYN -->|"upregulates"| IL12A["IL12A"]
    FYN -->|"regulates"| Kv1_3["Kv1.3"]
    FYN -->|"causes"| dopaminergic_neuron["dopaminergic neuron"]
    FYN -->|"activates"| neuroinflammation["neuroinflammation"]
    FYN -->|"activates"| microglia_activation["microglia activation"]
    FYN -->|"regulates"| Schizophrenia["Schizophrenia"]
    FYN -->|"regulates"| Epilepsy["Epilepsy"]
    FYN -->|"regulates"| Alzheimer["Alzheimer"]
    FYN -->|"regulates"| Autism["Autism"]
    JUN["JUN"] -->|"regulates"| FYN
    LCK["LCK"] -->|"activates"| FYN
    PKC["PKC"] -->|"activates"| FYN
    SRC["SRC"] -->|"activates"| FYN
    PI3K["PI3K"] -->|"regulates"| FYN
    GENES["GENES"] -->|"activates"| FYN
    NRF2["NRF2"] -->|"activates"| FYN
    CD36["CD36"] -->|"inhibits"| FYN
    AKT["AKT"] -->|"regulates"| FYN
    BACH1["BACH1"] -->|"activates"| FYN

Outgoing (318)

Target	Relation	Type	Str
STAT3	activates	gene	0.95
Dopaminergic Neuron Loss	causes	phenotype	0.95
RELN	interacts_with	entity	0.90
Mitochondrial Aggregation	causes	phenotype	0.90
Microglia Activation	causes	phenotype	0.90
Parkinson'S Disease	risk_factor_for	disease	0.90
NFE2L2	phosphorylates	protein	0.85
KCNA3	modulates	gene	0.85
KV1.3	upregulates	gene	0.85
Parkinson's Disease	risk_factor_for	disease	0.85
NEURONAL MIGRATION	involved_in	entity	0.85
PARKINSON'S DISEASE	risk_factor_for	disease	0.85
ALZHEIMER'S DISEASE	risk_factor_for	disease	0.85
KV1.3	modulates	gene	0.85
IL12A	upregulates	gene	0.80
KV1.3	phosphorylates	protein	0.80
Parkinson	associated_with	disease	0.75
Aging	expressed_in	disease	0.75
Alzheimer	implicated_in	disease	0.75
Kv1.3	regulates	protein	0.70
dopaminergic neuron	causes	cell_type	0.70
neuroinflammation	activates	process	0.70
microglia activation	activates	process	0.70
Apoptosis	activates	pathway	0.70
Parkinson's disease	associated_with	disease	0.70
Alzheimer's disease	associated_with	disease	0.70
MICROGLIA	activates	gene	0.70
PARKINSON	associated_with	gene	0.70
ALZHEIMER	implicated_in	gene	0.70
ALZHEIMER'S DISEASE	implicated_in	gene	0.70
SRC	causes	gene	0.65
UBIQUITIN	ubiquitinates	gene	0.65
Schizophrenia	regulates	disease	0.65
Epilepsy	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Autism	regulates	disease	0.65
Depression	regulates	disease	0.65
Bipolar	regulates	disease	0.65
Ms	regulates	disease	0.65
Ms	associated_with	disease	0.65
Als	associated_with	disease	0.65
Ms	activates	disease	0.65
Cancer	activates	disease	0.65
Als	activates	disease	0.65
Inflammation	inhibits	disease	0.65
Als	inhibits	disease	0.65
Hepatitis	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Ms	therapeutic_target	disease	0.65
Cancer	therapeutic_target	disease	0.65

Incoming (109)

Source	Relation	Type	Str
GSK3B	phosphorylates	gene	0.85
Apoer2	activates	protein	0.85
APOPTOSIS	activates	gene	0.70
DOPAMINERGIC	inhibits	cell_type	0.65
JUN	regulates	gene	0.60
DAB1	associated_with	gene	0.60
DRD2	associated_with	gene	0.60
LCK	activates	gene	0.60
PKC	activates	gene	0.60
SRC	associated_with	gene	0.60
CAMK2A	associated_with	gene	0.60
COMT	associated_with	gene	0.60
SLC6A3	associated_with	gene	0.60
SRC	activates	gene	0.60
PI3K	regulates	gene	0.60
NRF2	activates	gene	0.60
CD36	inhibits	gene	0.60
AKT	regulates	gene	0.60
BACH1	activates	gene	0.60
CUL3	regulates	gene	0.60
UBC	associated_with	gene	0.60
PI3K	phosphorylates	gene	0.60
CUL3	activates	gene	0.60
KEAP1	activates	gene	0.60
REELIN	associated_with	gene	0.60
NRF2	phosphorylates	gene	0.60
AKT	activates	gene	0.60
TNFA	causes	gene	0.60
STAT3	causes	gene	0.60
IL1B	causes	gene	0.60
BACH1	phosphorylates	entity	0.60
AKT	phosphorylates	entity	0.60
IL12A	causes	gene	0.60
HOMER1	associated_with	gene	0.60
SNCA	associated_with	gene	0.60
UBIQUITIN	activates	gene	0.60
AURKA	associated_with	gene	0.60
CASS4	associated_with	gene	0.60
GRN	inhibits	gene	0.60
PTK2B	inhibits	gene	0.60
APP	causes	gene	0.60
APOE	activates	gene	0.60
LRRK2	associated_with	gene	0.60
TAU	activates	gene	0.60
AKT1	associated_with	gene	0.60
EGFR	associated_with	gene	0.60
BACH1	degrades	gene	0.60
NRF2	degrades	gene	0.60
TAU	inhibits	gene	0.60
MAPK1	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

FYN

Understanding Entity Pages

Summary

Wiki Pages (21)

FYN — FYN Proto-Oncogene, Src Family Tyrosine Kinase

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