Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about KDM2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
KDM2B is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Infection. Connected to 10 entities in the SciDEX knowledge graph.
| Gene Symbol | KDM2B |
| Full Name | Lysine Demethylase 2B |
| Aliases | FBXL10, JHDM1B, NDY1, PCCX2 |
| Chromosome | 12q24.31 |
| Function | encodes a JmjC domain-containing histone demethylase that removes mono- and dimethyl marks from histone H3 lysine 36 (H3K36me1/2). |
| Gene Type | Protein-coding |
| Pathways | Epigenetic, Immune Response |
| UniProt ID | Q8NHM5 |
| Ensembl ID | ENSG00000089094 |
| OMIM | 609078 |
| GeneCards | KDM2B |
| Human Protein Atlas | KDM2B |
| HGNC | 13610 |
| Entrez Gene | 84678 |
| rs12304921 | Intronic SNP |
| Associated Diseases | neurodegeneration |
| Interactions | BRG1, IL-6, TNF-Α, IFN, TNF, IL6 |
| KG Connections | 9 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["KDM2B"]
N1["Infection"]
N0 -->|"activates"| N1
N2["IL-6"]
N0 -->|"activates"| N2
N3["TNF-Alpha"]
N0 -->|"activates"| N3
N4["BRG1"]
N0 -->|"activates"| N4
N5["IFN"]
N0 -->|"activates"| N5
N6["Epigenetic"]
N0 -->|"activates"| N6
N7["Immune Response"]
N0 -->|"activates"| N7
N8["TNF"]
N8 -->|"activates"| N0
N9["IL6"]
N9 -->|"activates"| N0
N10["neurodegeneration"]
N0 -->|"implicated in"| N10
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 disease
class N2 gene
class N3 gene
class N4 gene
class N5 gene
class N6 pathway
class N7 pathway
class N8 gene
class N9 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Infection | activates | disease | 0.65 |
| BRG1 | activates | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| IFN | activates | gene | 0.60 |
| Epigenetic | activates | pathway | 0.60 |
| Immune Response | activates | pathway | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||