gene

KDM2B

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about KDM2B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

9Connections
0Hypotheses
0Analyses
7Outgoing
2Incoming

Summary

KDM2B is a gene implicated in neurodegeneration research. Key relationships include: activates, implicated in. Associated with Infection. Connected to 10 entities in the SciDEX knowledge graph.

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🧬 Gene Info
Gene SymbolKDM2B
Full NameLysine Demethylase 2B
AliasesFBXL10, JHDM1B, NDY1, PCCX2
Chromosome12q24.31
Functionencodes a JmjC domain-containing histone demethylase that removes mono- and dimethyl marks from histone H3 lysine 36 (H3K36me1/2).
Gene TypeProtein-coding
PathwaysEpigenetic, Immune Response
UniProt IDQ8NHM5
Ensembl IDENSG00000089094
OMIM609078
GeneCardsKDM2B
Human Protein AtlasKDM2B
HGNC13610
Entrez Gene84678
rs12304921Intronic SNP
Associated Diseasesneurodegeneration
InteractionsBRG1, IL-6, TNF-Α, IFN, TNF, IL6
KG Connections9 knowledge graph edges
DatabasesGeneCardsNCBI GeneHPASTRING
🔮 Predicted Structure: KDM2B — AlphaFold Q8NHM5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (4)

Knowledge base pages for this entity

Canonical Page

KDM2B

gene · 1095 words

setd1a

gene · 2794 words

KDM4C

gene · 1208 words

Genes

index · 271 words

Pathway Diagram

flowchart TD
    N0["KDM2B"]
    N1["Infection"]
    N0 -->|"activates"| N1
    N2["IL-6"]
    N0 -->|"activates"| N2
    N3["TNF-Alpha"]
    N0 -->|"activates"| N3
    N4["BRG1"]
    N0 -->|"activates"| N4
    N5["IFN"]
    N0 -->|"activates"| N5
    N6["Epigenetic"]
    N0 -->|"activates"| N6
    N7["Immune Response"]
    N0 -->|"activates"| N7
    N8["TNF"]
    N8 -->|"activates"| N0
    N9["IL6"]
    N9 -->|"activates"| N0
    N10["neurodegeneration"]
    N0 -->|"implicated in"| N10

    classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
    classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
    classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
    classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
    classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
    class N1 disease
    class N2 gene
    class N3 gene
    class N4 gene
    class N5 gene
    class N6 pathway
    class N7 pathway
    class N8 gene
    class N9 gene

Outgoing (7)

TargetRelationTypeStr
Infectionactivatesdisease0.65
BRG1activatesgene0.60
IL-6activatesgene0.60
TNF-Αactivatesgene0.60
IFNactivatesgene0.60

Incoming (2)

SourceRelationTypeStr
TNFactivatesgene0.60
IL6activatesgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found