Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about BRG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
BRG1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with Als, Cancer, Carcinoma. Connected to 122 entities in the SciDEX knowledge graph.
| Gene Symbol | BRG1 (SMARCA4) |
| Full Name | SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin |
| Chromosome | 19q13.2 |
| Function | SMARCA4 encodes the central ATPase of the SWI/SNF complex. |
| Primary Expression | neural progenitors, increases with differentiation |
| Molecular Weight | 185 kDa |
| Pathways | Epigenetic |
| UniProt ID | P51532 |
| NCBI Gene ID | 6597 |
| Ensembl ID | ENSG00000127616 |
| OMIM | 603254 |
| Associated Diseases | Cancer, Colorectal Cancer, Inflammatory Bowel Disease, Tumor |
| Known Drugs/Compounds | rapamycin |
| Interactions | AKT, ERN1, LC3, MELK, MTOR, NOD2 |
| KG Connections | 229 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
flowchart TD
BRG1["BRG1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
BRG1["BRG1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
BRG1["BRG1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
BRG1["BRG1"] -->|"therapeutic target"| Cancer["Cancer"]
BRG1["BRG1"] -->|"therapeutic target"| Als["Als"]
BRG1["BRG1"] -->|"therapeutic target"| Inflammation["Inflammation"]
BRG1["BRG1"] -->|"therapeutic target"| Ms["Ms"]
BRG1["BRG1"] -->|"expressed in"| Als["Als"]
BRG1["BRG1"] -->|"expressed in"| Cancer["Cancer"]
BRG1["BRG1"] -->|"therapeutic target"| NRCAM["NRCAM"]
BRG1["BRG1"] -->|"therapeutic target"| NOTCH2["NOTCH2"]
BRG1["BRG1"] -->|"regulates"| EP300["EP300"]
style BRG1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
style Als fill:#ef5350,stroke:#333,color:#e0e0e0
style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
style NRCAM fill:#4a1a6b,stroke:#333,color:#e0e0e0
style NOTCH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
style EP300 fill:#4a1a6b,stroke:#333,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Fibrosis | therapeutic_target | disease | 0.65 |
| Hepatitis | therapeutic_target | disease | 0.65 |
| Carcinoma | therapeutic_target | disease | 0.65 |
| Cancer | therapeutic_target | disease | 0.65 |
| Als | therapeutic_target | disease | 0.65 |
| Inflammation | therapeutic_target | disease | 0.65 |
| Ms | therapeutic_target | disease | 0.65 |
| Als | expressed_in | disease | 0.65 |
| Cancer | expressed_in | disease | 0.65 |
| Prostate Cancer | therapeutic_target | disease | 0.65 |
| Infection | therapeutic_target | disease | 0.65 |
| Hepatocellular Carcinoma | therapeutic_target | disease | 0.65 |
| Colorectal Cancer | therapeutic_target | disease | 0.65 |
| Liver Cancer | therapeutic_target | disease | 0.65 |
| Pulmonary Fibrosis | therapeutic_target | disease | 0.65 |
| Lung Cancer | therapeutic_target | disease | 0.65 |
| Pancreatic Cancer | therapeutic_target | disease | 0.65 |
| Gastric Cancer | therapeutic_target | disease | 0.65 |
| Colorectal Cancer | associated_with | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| Inflammatory Bowel Disease | associated_with | disease | 0.65 |
| Infection | activates | disease | 0.65 |
| Tumor | expressed_in | disease | 0.65 |
| NRCAM | therapeutic_target | gene | 0.60 |
| NOTCH2 | therapeutic_target | gene | 0.60 |
| EP300 | regulates | gene | 0.60 |
| CTNNB1 | regulates | gene | 0.60 |
| NEUROD1 | therapeutic_target | gene | 0.60 |
| MYC | therapeutic_target | gene | 0.60 |
| VEGFA | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| FOXM1 | regulates | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| SMARCA4 | regulates | gene | 0.60 |
| TERT | therapeutic_target | gene | 0.60 |
| FZD7 | therapeutic_target | gene | 0.60 |
| JAG1 | therapeutic_target | gene | 0.60 |
| MITF | therapeutic_target | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| AXIN2 | regulates | gene | 0.60 |
| CD44 | therapeutic_target | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| ATF3 | therapeutic_target | gene | 0.60 |
| IL10 | therapeutic_target | gene | 0.60 |
| DKK1 | therapeutic_target | gene | 0.60 |
| PPARD | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| APC | regulates | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| FGF20 | therapeutic_target | gene | 0.60 |
| ATF2 | regulates | gene | 0.60 |
| AMBRA1 | regulates | gene | 0.60 |
| ALDH1A1 | therapeutic_target | gene | 0.60 |
| MITF | therapeutic_target | gene | 0.60 |
| LEF1 | therapeutic_target | gene | 0.60 |
| ABCB1 | therapeutic_target | gene | 0.60 |
| CLDN1 | therapeutic_target | gene | 0.60 |
| JAG1 | therapeutic_target | gene | 0.60 |
| CTNNB1 | regulates | gene | 0.60 |
| AXIN1 | regulates | gene | 0.60 |
| EP300 | regulates | gene | 0.60 |
| CREBBP | regulates | gene | 0.60 |
| FGF18 | therapeutic_target | gene | 0.60 |
| GAIN | therapeutic_target | gene | 0.60 |
| RIPK2 | associated_with | gene | 0.60 |
| BECN1 | associated_with | gene | 0.60 |
| TNFA | associated_with | gene | 0.60 |
| STAT3 | associated_with | gene | 0.60 |
| ASC | associated_with | gene | 0.60 |
| PI3K | associated_with | gene | 0.60 |
| TNF | activates | gene | 0.60 |
| IL6 | activates | gene | 0.60 |
| KDM2B | activates | gene | 0.60 |
| PTEN | expressed_in | gene | 0.60 |
| PI3K | therapeutic_target | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| ERN1 | associated_with | gene | 0.60 |
| PYCARD | associated_with | gene | 0.60 |
| NOD2 | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| ASC | activates | gene | 0.60 |
| APC | regulates | gene | 0.60 |
| AXIN2 | regulates | gene | 0.60 |
| CANCER | expressed_in | gene | 0.60 |
| AUTOPHAGY | expressed_in | gene | 0.60 |
| CANCER | therapeutic_target | gene | 0.60 |
| CDH1 | regulates | gene | 0.60 |
| INFLAMMATION | therapeutic_target | gene | 0.60 |
| BAMBI | therapeutic_target | gene | 0.60 |
| IL-6 | activates | gene | 0.60 |
| TNF-Α | activates | gene | 0.60 |
| AND | therapeutic_target | gene | 0.60 |
| FBXW7 | inhibits | gene | 0.60 |
| NLR | associated_with | gene | 0.60 |
| ATG | activates | gene | 0.60 |
| rapamycin | targets | drug | 0.60 |
| BMAL1 | activates | gene | 0.55 |
| ULK1 | activates | gene | 0.50 |
| TNFA | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||