protein

BRG1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about BRG1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

229Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

BRG1 is a protein involved in neurodegeneration research. Key relationships include: therapeutic target, associated with, regulates. Associated with Als, Cancer, Carcinoma. Connected to 122 entities in the SciDEX knowledge graph.

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🔬 Protein Info
Gene SymbolBRG1 (SMARCA4)
Full NameSWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin
Chromosome19q13.2
FunctionSMARCA4 encodes the central ATPase of the SWI/SNF complex.
Primary Expressionneural progenitors, increases with differentiation
Molecular Weight185 kDa
PathwaysEpigenetic
UniProt IDP51532
NCBI Gene ID6597
Ensembl IDENSG00000127616
OMIM603254
Associated DiseasesCancer, Colorectal Cancer, Inflammatory Bowel Disease, Tumor
Known Drugs/Compoundsrapamycin
InteractionsAKT, ERN1, LC3, MELK, MTOR, NOD2
KG Connections229 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: BRG1 — AlphaFold P51532 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

BRG1 Gene

gene · 696 words

NRF2 Oxidative Stress Pathway

mechanism · 5315 words

Epigenetic Dysregulation in Neurodegeneration

mechanism · 4376 words

Epigenetic Alterations in Alzheimer's Disease

mechanism · 4331 words

Transcriptional Regulation in Neurodegeneration

mechanism · 3716 words

SETD1B

gene · 3299 words

Pathway Diagram

flowchart TD
    BRG1["BRG1"] -->|"therapeutic target"| Fibrosis["Fibrosis"]
    BRG1["BRG1"] -->|"therapeutic target"| Hepatitis["Hepatitis"]
    BRG1["BRG1"] -->|"therapeutic target"| Carcinoma["Carcinoma"]
    BRG1["BRG1"] -->|"therapeutic target"| Cancer["Cancer"]
    BRG1["BRG1"] -->|"therapeutic target"| Als["Als"]
    BRG1["BRG1"] -->|"therapeutic target"| Inflammation["Inflammation"]
    BRG1["BRG1"] -->|"therapeutic target"| Ms["Ms"]
    BRG1["BRG1"] -->|"expressed in"| Als["Als"]
    BRG1["BRG1"] -->|"expressed in"| Cancer["Cancer"]
    BRG1["BRG1"] -->|"therapeutic target"| NRCAM["NRCAM"]
    BRG1["BRG1"] -->|"therapeutic target"| NOTCH2["NOTCH2"]
    BRG1["BRG1"] -->|"regulates"| EP300["EP300"]
    style BRG1 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style Fibrosis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Hepatitis fill:#ef5350,stroke:#333,color:#e0e0e0
    style Carcinoma fill:#ef5350,stroke:#333,color:#e0e0e0
    style Cancer fill:#ef5350,stroke:#333,color:#e0e0e0
    style Als fill:#ef5350,stroke:#333,color:#e0e0e0
    style Inflammation fill:#ef5350,stroke:#333,color:#e0e0e0
    style Ms fill:#ef5350,stroke:#333,color:#e0e0e0
    style NRCAM fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style NOTCH2 fill:#4a1a6b,stroke:#333,color:#e0e0e0
    style EP300 fill:#4a1a6b,stroke:#333,color:#e0e0e0

Outgoing (165)

TargetRelationTypeStr
Fibrosistherapeutic_targetdisease0.65
Hepatitistherapeutic_targetdisease0.65
Carcinomatherapeutic_targetdisease0.65
Cancertherapeutic_targetdisease0.65
Alstherapeutic_targetdisease0.65

Incoming (64)

SourceRelationTypeStr
FGF20therapeutic_targetgene0.60
ATF2regulatesgene0.60
AMBRA1regulatesgene0.60
ALDH1A1therapeutic_targetgene0.60
MITFtherapeutic_targetgene0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found