Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about LAPTM4B: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | LAPTM4B |
| Full Name | Lysosomal Associated Transmembrane Protein 4 Beta |
| Chromosome | 2q21.1 |
| Function | is an important component in the neurobiology of neurodegenerative diseases. |
| Primary Expression | cancers and has been studied extensively as a cancer biomarker |
| Amino Acids | 347 aa |
| Pathways | mtor, mTOR |
| UniProt ID | [Q9Y5G5](https://www.uniprot.org/uniprot/Q9Y5G5) |
| Ensembl ID | ENSG00000167996 |
| GeneCards | LAPTM4B |
| Human Protein Atlas | LAPTM4B |
| Membrane integration | Multiple transmembrane domains anchor it in lysosomal membranes |
| Lysosomal trafficking | Participates in vesicular transport to and from lysosomes |
| Autophagy support | Contributes to autophagosome-lysosome fusion events |
| Cell cycle regulation | Modulates cell cycle progression |
| Associated Diseases | neurodegeneration |
| Interactions | HDAC2, AUTOPHAGY, AND, CANCER, LYSOSOME |
| KG Connections | 23 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
N0["LAPTM4B"]
N1["HDAC2"]
N1 -->|"associated with"| N0
N1 -->|"binds"| N0
N2["Autophagy"]
N0 -->|"involved in"| N2
N3["Als"]
N0 -->|"activates"| N3
N4["Cancer"]
N0 -->|"activates"| N4
N5["ALS"]
N0 -->|"activates"| N5
N6["Carcinoma"]
N0 -->|"activates"| N6
N0 -->|"activates"| N1
N7["AUTOPHAGY"]
N0 -->|"activates"| N7
N0 -->|"activates"| N2
N8["AND"]
N0 -->|"activates"| N8
N9["CANCER"]
N0 -->|"activates"| N9
N10["LYSOSOME"]
N10 -->|"activates"| N0
N7 -->|"activates"| N0
classDef gene fill:#1a3a2a,stroke:#4caf50,color:#e0e0e0
classDef protein fill:#1a2a3a,stroke:#4fc3f7,color:#e0e0e0
classDef disease fill:#3a1a1a,stroke:#ef5350,color:#e0e0e0
classDef pathway fill:#2a1a3a,stroke:#ce93d8,color:#e0e0e0
classDef mechanism fill:#2a2a1a,stroke:#ffd54f,color:#e0e0e0
class N1 gene
class N3 disease
class N4 disease
class N5 disease
class N6 disease
class N7 gene
class N8 gene
class N9 gene
class N10 gene| Target | Relation | Type | Str |
|---|---|---|---|
| Autophagy | involved_in | process | 0.88 |
| Als | activates | disease | 0.65 |
| Cancer | activates | disease | 0.65 |
| ALS | activates | disease | 0.65 |
| Carcinoma | activates | disease | 0.65 |
| HDAC2 | activates | gene | 0.60 |
| AUTOPHAGY | activates | gene | 0.60 |
| Autophagy | activates | pathway | 0.60 |
| AND | activates | gene | 0.60 |
| CANCER | activates | gene | 0.60 |
| autophagy pathway | participates_in | pathway | 0.60 |
| HDAC2 | associated_with | gene | 0.50 |
| HDAC2 | regulates | gene | 0.50 |
| LYSOSOME | activates | gene | 0.50 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||