| Gene Symbol | HDAC2 |
| Full Name | Histone Deacetylase 2 |
| Chromosome | 6q21 |
| Function | HDAC2 encodes histone deacetylase 2, a class I histone deacetylase that regulates gene expression through chromatin remodeling. |
| Primary Expression | neurons and plays critical roles in synaptic plasticity, memory formation, and transcriptional regulation |
| Pathways | Apoptosis, Dna Repair, Epigenetic, Hippo, Notch |
| UniProt ID | [Q92769](https://www.uniprot.org/uniprot/Q92769) |
| Ensembl ID | ENSG00000196591 |
| OMIM | 605185 |
| GeneCards | HDAC2 |
| Human Protein Atlas | HDAC2 |
| Associated Diseases | Als, Alzheimer, Cancer, Colorectal Cancer, Gastric Cancer, Hepatocellular Carcinoma |
| Known Drugs/Compounds | SULFORAPHANE |
| Interactions | HDAC3, TRKB, BDNF, EGFR, EP300, SENP1 |
| SciDEX Hypotheses | HDAC2-Specific Repression of PU.1 Pioneer Factor T |
| KG Connections | 397 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |