| Gene Symbol | HDAC2 |
| Full Name | Histone Deacetylase 2 |
| Chromosome | 6q21 |
| Function | HDAC2 encodes histone deacetylase 2, a class I histone deacetylase that regulates gene expression through chromatin remodeling. |
| Primary Expression | neurons and plays critical roles in synaptic plasticity, memory formation, and transcriptional regulation |
| Pathways | Apoptosis, Dna Repair, Epigenetic, Hippo, Notch |
| UniProt ID | [Q92769](https://www.uniprot.org/uniprot/Q92769) |
| Ensembl ID | ENSG00000196591 |
| OMIM | 605185 |
| GeneCards | HDAC2 |
| Human Protein Atlas | HDAC2 |
| Associated Diseases | Als, Alzheimer, Cancer, Colorectal Cancer, Gastric Cancer, Hepatocellular Carcinoma |
| Known Drugs/Compounds | butyrate, SULFORAPHANE |
| Interactions | ACAT1, ACETYL-COA, Actin, Adiponectin, AKT, ALZHEIMER |
| SciDEX Hypotheses | Gut-derived butyrate reprograms microglia for amyl HDAC2-Specific Repression of PU.1 Pioneer Factor T Gut butyrate deficiency impairs microglial amyloid (+1 more) |
| KG Connections | 403 knowledge graph edges |
| Databases | GeneCardsNCBI GeneHPASTRING |
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