Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about Lactate shuttle: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
No AI portrait yet
| Target | Relation | Type | Str |
|---|---|---|---|
| Intercellular Energy Supply | contributes_to | process | 0.85 |
| Source | Relation | Type | Str |
|---|---|---|---|
| PAL | promotes | drug | 0.95 |
| glycolysis | interacts_with | pathway | 0.90 |
| GLUT1 | involved_in | gene | 0.85 |
| LDHA | activates | gene | 0.70 |
| MCT1 | regulates | protein | 0.70 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Astrocytic Lactate Shuttle Enhancement for Grid Cell Bioener | 0.529 | neurodegeneration | Selective vulnerability of entorhinal co |
| Astrocyte-Neuron Lactate Shuttle (H6): Metabolic Coupling Re | 0.500 | neurodegeneration | Does restoring neuronal AMPK activity re |
| Lactate Shuttle Pathway Enhancement | 0.455 | neurodegeneration | Which specific metabolic pathways in APO |
| Astrocyte-Neuron Lactate Shuttle via SST-Mediated Metabolic | 0.350 | Alzheimer's disease | Closed-loop transcranial focused ultraso |
| Astrocyte-Neuron Lactate Shuttle Enhancement via Pharmacolog | 0.308 | metabolomics | Metabolomic signatures of neurodegenerat |
Scientific analyses that reference this entity
neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| No experiments found | |||||||
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| miR-375 protects against acetaminophen-induced acute liver failure by orchestrat [PMID:40598772] | Wang Y, Liu J, Zhu S, Hu S, Chen X, Mand | Mol Ther | 2025 | 1 |
| Defective thyroid hormone transport to the brain leads to astroglial alterations [PMID:39097035] | Guillén-Yunta M, García-Aldea Á, Valcárc | Neurobiol Dis | 2024 | 1 |
| The SLC16 gene family - structure, role and regulation in health and disease. [PMID:23506875] | Halestrap AP | Mol Aspects Med | 2013 | 1 |
| Bionanoconjugates in Neurodegeneration: Peptide-Nanoparticle Alliances for Next- [PMID:41199078] | ["Ranjitha V", "Kumar A", "Kaalappa P"] | Pharmaceutical research | 2025 | 0 |
| Tiratricol: First Approval. [PMID:40549098] | ["Lamb Y"] | Drugs | 2025 | 0 |
| Structural insights into brain thyroid hormone transport via MCT8 and OATP1C1. [PMID:40680733] | Ge Y, Dou T, Nguyen TU, Yadav GP, Wensel | Cell | 2025 | 0 |
| Exosomes as nanocarriers for brain-targeted delivery of therapeutic nucleic acid [PMID:40533746] | ["Sanadgol N", "Abedi M", "Hashemzaei M" | Journal of nanobiotechnology | 2025 | 0 |
| The interactions between monocarboxylate transporter genes MCT1, MCT2, and MCT4 [PMID:39934699] | Maculewicz E, Mastalerz A, Garbacz A, Mr | BMC genomics | 2025 | 0 |
| Adrenergic regulation of astroglial aerobic glycolysis and lipid metabolism: Tow [PMID:37094775] | ["Zorec R", "Vardjan N"] | Neurobiology of disease | 2023 | 0 |
| Tsh Induces Agrp1 Neuron Proliferation in Oatp1c1-Deficient Zebrafish. [PMID:36150888] | Wasserman-Bartov T, Admati I, Lebenthal- | The Journal of neuroscience : | 2022 | 0 |
| The tissue expression of MCT3, MCT8, and MCT9 genes in women with breast cancer. [PMID:34097251] | Sohrabi E, Moslemi M, Rezaie E, Nafissi | Genes & genomics | 2021 | 0 |
| Thyroid Hormone Transporters. [PMID:31754699] | ["Groeneweg S", "van Geest F", "Peeters | Endocrine reviews | 2020 | 0 |
| Neural Alterations and Hyperactivity of the Hypothalamic-Pituitary-Thyroid Axis [PMID:31797746] | ["Admati I", "Wasserman-Bartov T", "Tovi | Thyroid : official journal of | 2020 | 0 |
| Disease characteristics of MCT8 deficiency: an international, retrospective, mul [PMID:32559475] | Groeneweg S, van Geest FS, Abacı A, Alca | The lancet. Diabetes & endocri | 2020 | 0 |
| Nonbiological maternal risk factor for low birth weight on Latin America: a syst [PMID:23386023] | ["da Silva T"] | Einstein (Sao Paulo, Brazil) | 2012 | 0 |
| Thyroid hormone transporters in the brain. [PMID:20879691] | Braun D, Wirth EK, Schweizer U | Reviews in the neurosciences | 2010 | 0 |
| Polo-like kinase 1: target and regulator of anaphase-promoting complex/cyclosome [PMID:16849530] | ["Eckerdt F", "Strebhardt K"] | Cancer research | 2006 | 0 |
Multi-agent debates referencing this entity
closed · Rounds: 4 · Score: 0.70 · 2026-04-21
closed · Rounds: 4 · Score: 0.70 · 2026-04-16
Hypotheses and analyses mentioning Lactate shuttle in their description or question text
No additional research found