protein

MCT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MCT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

97Connections

5Hypotheses

6Analyses

50Outgoing

30Incoming

0Experiments

8Debates

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🔬 Protein Info

Gene Symbol	MCT1
Pathways	Energy Metabolism, Tumor Cell Metabolism, unfolded protein response, oxidative stress response, blood-brain barrier
GeneCards	MCT1
Human Protein Atlas	MCT1
Associated Diseases	ALS, Alzheimer disease, axon survival, dementia, glioblastoma
Known Drugs/Compounds	AZD3965, BHBA, LACTATE, metformin
Interactions	AHR, AMPK, APP, Basigin, BASIGIN, Embigin
KG Connections	94 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Pathway Diagram

graph TD
    MCT1["MCT1"] -->|"catalyzes"| L_lactate["L-lactate"]
    style L_lactate fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MCT1["MCT1"] -->|"interacts"| BASIGIN["BASIGIN"]
    style BASIGIN fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MCT1["MCT1"] -->|"catalyzes"| Pyruvate["Pyruvate"]
    style Pyruvate fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MCT1["MCT1"] -->|"involved in"| Energy_Metabolism["Energy Metabolism"]
    style Energy_Metabolism fill:#1a2a3a,stroke:#81c784,stroke-width:1px,color:#fff
    MCT1["MCT1"] -->|"involved in"| T_Lymphocyte_Activation["T-Lymphocyte Activation"]
    style T_Lymphocyte_Activation fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    MCT1["MCT1"] -->|"expressed in"| Brain["Brain"]
    style Brain fill:#1a2a3a,stroke:#4fc3f7,stroke-width:1px,color:#fff
    MCT1["MCT1"] -->|"mediates"| Water_Transport["Water Transport"]
    style Water_Transport fill:#1a2a3a,stroke:#ffd54f,stroke-width:1px,color:#fff
    SLC16A1["SLC16A1"] -->|"encodes"| MCT1["MCT1"]
    style SLC16A1 fill:#1a2a3a,stroke:#ce93d8,stroke-width:1px,color:#fff
    style MCT1 fill:#006494,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0,font-weight:bold

Outgoing (67)

Target	Relation	Type	Str
h-e5f17434c3	targeted_by	hypothesis	1.00
Basigin	interacts_with	protein	1.00
Pyruvate	transports	compound	1.00
Ketone Bodies	transports	compound	1.00
L-Lactate	transports	compound	1.00
Embigin	interacts_with	protein	1.00
L-lactate	catalyzes	compound	1.00
BASIGIN	interacts_with	protein	1.00
Pyruvate	catalyzes	compound	1.00
Energy Metabolism	involved_in	pathway	0.95
l-lactate transport	mediates	process	0.95
axon survival	decreases_risk	phenotype	0.90
axonal lactate transport	regulates	phenotype	0.90
T-Lymphocyte Activation	involved_in	process	0.90
Brain	expressed_in	cell_type	0.90
Tumor Cell Metabolism	involved_in	pathway	0.90
Cancer	therapeutic_target	disease	0.85
brain energy metabolism	involved_in	pathway	0.85
Ketogenic Diet	upregulates	drug	0.85
skeletal muscle energy metabolism	involved_in	pathway	0.85
Water Transport	mediates	process	0.80
neurons	expressed_in	cell_type	0.75
Lactate shuttle	regulates	pathway	0.70
myelin sheaths	associated_with	brain_region	0.70
endothelial cells	expressed_in	cell_type	0.70
myelin_sheath	localizes_to	process	0.70
astrocyte_microglia_metabolic_cross_talk	regulates	phenotype	0.70
astrocyte metabolic cooperativity	regulates	phenotype	0.70
ketone body transport	regulates	pathway	0.70
Alzheimer disease	associated_with	disease	0.70
lactate transport	regulates	phenotype	0.70
oxidative stress response	participates_in	pathway	0.65
unfolded protein response	participates_in	pathway	0.65
blood-brain barrier	participates_in	pathway	0.65
Notch signaling	participates_in	pathway	0.60
autophagy pathway	participates_in	pathway	0.60
TJP1	activates	gene	0.60
glioblastoma	expressed_in	disease	0.60
SLC16A3	associated_with	gene	0.60
ALS	associated_with	disease	0.60
SLC16A1	associated_with	gene	0.60
SLC16A1	expressed_in	gene	0.60
glioblastoma	associated_with	disease	0.60
dementia	associated_with	disease	0.60
PDH	activates	gene	0.60
LACTATE	interacts_with	drug	0.60
TUMOR PROGRESSION	contributes_to	pathway	0.60
AMPK	associated_with	protein	0.60
BHBA	interacts_with	drug	0.60
SLC16A1	regulates	gene	0.55

Incoming (30)

Source	Relation	Type	Str
h-e5f17434c3	targets	hypothesis	1.00
SLC16A1	encodes	gene	1.00
PAL	upregulates	compound	0.85
AZD3965	inhibits	drug	0.70
BDNF	expressed_in	gene	0.60
HMGCR	expressed_in	gene	0.60
HK2	activates	gene	0.60
LDHA	activates	gene	0.60
SLC16A1	interacts_with	gene	0.60
IDH1	interacts_with	gene	0.60
LDHA	interacts_with	gene	0.60
GBM	expressed_in	gene	0.60
IDH1	expressed_in	gene	0.60
LDHA	expressed_in	gene	0.60
HMGCS2	interacts_with	gene	0.60
33440165	is important for	paper	0.60
GAT1	translocates_to	gene	0.60
AMPK	activates	gene	0.55
AHR	activates	gene	0.55
metformin	targets	drug	0.55
GFAP	activates	gene	0.55
GFAP	associated_with	gene	0.55
APP	activates	gene	0.55
GFAP	regulates	gene	0.55
GFAP	inhibits	gene	0.55
JAK	inhibits	gene	0.55
GBM	co_expressed_with	gene	0.50
ATP	co_expressed_with	protein	0.50
HK2	co_expressed_with	gene	0.50
HMGCS2	associated_with	gene	0.35

Targeting Hypotheses (5)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
SARM1-Mediated NAD+ Depletion as Terminal Executor of MCT1-D	0.698	neurodegeneration	What is the molecular mechanism by which
Astrocyte MCT1/MCT4 Ratio Disruption with Metabolic Uncoupli	0.668	alzheimers	Cell type vulnerability in Alzheimers Di
Restoration of Neuronal Ketone Body Utilization via MCT1 Upr	0.459	metabolomics	Metabolomic signatures of neurodegenerat
NAD+-Dependent Transcriptional Upregulation of MCT1 to Resto	0.380	metabolomics	Metabolomic signatures of neurodegenerat
NAD+-Dependent Upregulation of MCT1 Expression to Restore Ne	0.380	metabolomics	Metabolomic signatures of neurodegenerat

Mentioning Analyses (6)

Scientific analyses that reference this entity

Spatially Resolved Oligodendrocyte-Astrocyte Communication Networks Disrupted in

neurodegeneration | 2026-04-27 | 0 hypotheses

scRNA-seq Processing and Cell Type Annotation of AD Brain

neurodegeneration | 2026-04-16 | 1 hypotheses Top: 0.618

Metabolomic signatures of neurodegeneration: metabolic reprogramming in aging br

metabolomics | 2026-04-16 | 13 hypotheses Top: 0.547

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.698

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

neurodegeneration | 2026-04-08 | 7 hypotheses Top: 0.455

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Transcriptomic cytoarchitecture reveals principles of human neocortex organizati [PMID:37824655]	Jorstad NL, Close J, Johansen N, Yanny A	Science	2023	186
Ion Channel-Extracellular Matrix Interplay in Colorectal Cancer: A Network-Based [PMID:40507957]	Terzi A, Maqoud F, Guido D, Mallardi D,	International journal of molec	2025	0
Direct mitochondrial import of lactate supports resilient carbohydrate oxidation [PMID:39416192]	Cluntun AA, Visker JR, Velasco-Silva JN,	bioRxiv : the preprint server	2024	0
Indole Derivatives as New Structural Class of Potent and Antiproliferative Inhib [PMID:36584238]	Puri S, Stefan K, Khan SL, Pahnke J, Ste	Journal of medicinal chemistry	2023	0
[WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268]	Wieschollek S, Forster S, Megerle K	Handchirurgie, Mikrochirurgie,	2022	0
SLC gene mutations and pediatric neurological disorders: diverse clinical phenot [PMID:34797406]	Mir A, Almudhry M, Alghamdi F, Albaradie	Human genetics	2022	0
Amyloid-β42 stimulated hippocampal lactate release is coupled to glutamate uptak [PMID:35177691]	Hascup ER, Sime LN, Peck MR, Hascup KN	Scientific reports	2022	0
Editor's Review and Introduction: Cognition-Inspired Artificial Intelligence. [PMID:35853452]	Cassenti DN, Veksler VD, Ritter FE	Topics in cognitive science	2022	0
Innovations in systemic sclerosis. [PMID:34483059]	Sindhu R Johnson	Best practice & research.	2021	0
Macrophage monocarboxylate transporter 1 promotes peripheral nerve regeneration [PMID:34491913]	Jha MK, Passero JV, Rawat A, Ament XH, Y	The Journal of clinical invest	2021	0
Genome sequencing analysis identifies new loci associated with Lewy body dementi [PMID:33589841]	Chia R, Sabir MS, Bandres-Ciga S, Saez-A	Nature genetics	2021	0
Complete Genome Sequence of Geobacter sp. Strain FeAm09, a Moderately Acidophili [PMID:33446582]	Yadav P, Antony-Babu S, Hayes E, Healy O	Microbiology resource announce	2021	0
Engineering complex communities by directed evolution. [PMID:33986540]	Chang CY, Vila JCC, Bender M, Li R, Mank	Nature ecology & evolution	2021	0
Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100]	Tajika T, Kuboi T, Endo F, Hatori Y, Sai	Progress in rehabilitation med	2021	0
Neural crest-derived tumor neuroblastoma and melanoma share 1p13.2 as susceptibi [PMID:31605138]	Avitabile M, Succoio M, Testori A, Cardi	Carcinogenesis	2020	0
Manassantin B shows antiviral activity against coxsackievirus B3 infection by ac [PMID:31253850]	Song JH, Ahn JH, Kim SR, Cho S, Hong EH,	Scientific reports	2019	0
Brain Glucose Metabolism: Integration of Energetics with Function. [PMID:30565508]	Dienel GA	Physiological reviews	2019	0
A ketogenic drink improves brain energy and some measures of cognition in mild c [PMID:31027873]	Fortier M, Castellano CA, Croteau E, Lan	Alzheimer's & dementia : the j	2019	0
Epigenetic dysregulation in chronic myeloid leukaemia: A myriad of mechanisms an [PMID:28778403]	Koschmieder S, Vetrie D	Seminars in cancer biology	2018	0
Perspectives on oral squamous cell carcinoma prevention-proliferation, position, [PMID:29752860]	Thomson PJ	Journal of oral pathology & me	2018	0

Debates (8)

Multi-agent debates referencing this entity

What spatially resolved cell-cell communication networks between oligodendrocyte

closed · Rounds: 6 · Score: 0.83 · 2026-04-27

Can standardized scRNA-seq processing and automated annotation identify novel ce

closed · Rounds: 4 · Score: 0.70 · 2026-04-21

What are the key metabolic alterations detectable in brain tissue, CSF, and bloo

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Does the hybrid DAM + interferon-response microglial population represent a nove

closed · Rounds: 4 · Score: 0.70 · 2026-04-16

closed · Rounds: 4 · Score: 0.95 · 2026-04-15

The study shows that MCT1 disruption leads to axon degeneration and neuron death

closed · Rounds: 4 · Score: 0.78 · 2026-04-14

The study shows that MCT1 disruption leads to axon degeneration and neuron death

closed · Rounds: 4 · Score: 0.82 · 2026-04-13

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

closed · Rounds: 4 · Score: 0.92 · 2026-04-09

Related Research

Hypotheses and analyses mentioning MCT1 in their description or question text

No additional research found

MCT1

Understanding Entity Pages

Pathway Diagram

Outgoing (67)

Incoming (30)

Targeting Hypotheses (5)

Mentioning Analyses (6)

Spatially Resolved Oligodendrocyte-Astrocyte Communication Networks Disrupted in

scRNA-seq Processing and Cell Type Annotation of AD Brain

Metabolomic signatures of neurodegeneration: metabolic reprogramming in aging br

What is the molecular mechanism by which oligodendroglial MCT1 disruption causes

Which specific metabolic pathways in APOE4+ microglia are most therapeutically t

Metabolic reprogramming in neurodegenerative disease

Experiments (0)

Related Papers (20)

Debates (8)

What spatially resolved cell-cell communication networks between oligodendrocyte

Can standardized scRNA-seq processing and automated annotation identify novel ce

What are the key metabolic alterations detectable in brain tissue, CSF, and bloo

Does the hybrid DAM + interferon-response microglial population represent a nove

The study shows that MCT1 disruption leads to axon degeneration and neuron death

The study shows that MCT1 disruption leads to axon degeneration and neuron death

While APOE4 disrupts microglial metabolism broadly, the debate didn't identify w

Related Research