concept

LDHA

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about LDHA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

233Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

0Experiments

4Debates

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💡 Concept Info

Name	LDHA
Key Genes/Proteins	ABCA1, ACAT1, ACC, ACLY, ACSL5, Akt
Related Diseases	Aging, Als, ALS
Related Pathways	aerobic glycolysis

Pathway Diagram

graph TD
    LDHA["LDHA"]
    LDHA -->|"involved_in"| Glycolysis["Glycolysis"]
    LDHA -->|"activates"| Tumor["Tumor"]
    LDHA -->|"activates"| Cancer["Cancer"]
    LDHA -->|"inhibits"| Neuroinflammation["Neuroinflammation"]
    LDHA -->|"inhibits"| Inflammation["Inflammation"]
    LDHA -->|"inhibits"| ALS["ALS"]
    LDHA -->|"inhibits"| Traumatic_Brain_Injury["Traumatic Brain Injury"]
    LDHA -->|"activates"| Carcinoma["Carcinoma"]
    LDHA -->|"activates"| Als["Als"]
    LDHA -->|"activates"| Metabolic_Syndrome["Metabolic Syndrome"]
    EEF2["EEF2"] -->|"binds"| LDHA
    HIF["HIF"] -->|"activates"| LDHA
    PI3K["PI3K"] -->|"activates"| LDHA
    HK2["HK2"] -->|"activates"| LDHA
    MTOR["MTOR"] -->|"activates"| LDHA
    SRC["SRC"] -->|"activates"| LDHA
    GENES["GENES"] -->|"activates"| LDHA
    HK1["HK1"] -->|"activates"| LDHA
    AMPK["AMPK"] -->|"activates"| LDHA
    G6PD["G6PD"] -->|"activates"| LDHA

Outgoing (149)

Target	Relation	Type	Str
h-b701c493b0	targeted_by	hypothesis	1.00
h-b2ebc9b2	targeted_by	hypothesis	1.00
lactate	regulates	pathway	0.95
bactericidal activity	promotes	phenotype	0.90
lactate production	regulates	process	0.90
Glycolysis	involved_in	process	0.90
aerobic glycolysis	involved_in	pathway	0.90
Lactate Production	mediates	process	0.85
Lactate Production	upregulates	process	0.80
unfolded protein response	participates_in	pathway	0.75
Lactate/Pyruvate Ratio	regulates	process	0.70
ROS	regulates	phenotype	0.70
ROS	activates	phenotype	0.70
lactate shuttle	activates	phenotype	0.70
ASTROCYTES	activates	cell_type	0.70
Traumatic Brain Injury	inhibits	disease	0.65
ALS	inhibits	disease	0.65
Neuroinflammation	inhibits	disease	0.65
Inflammation	inhibits	disease	0.65
ALS	associated_with	disease	0.65
Tumor	associated_with	disease	0.65
GLYCOLYSIS	regulates	phenotype	0.65
Glioblastoma	associated_with	disease	0.65
Aging	associated_with	disease	0.65
Als	inhibits	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Als	associated_with	disease	0.65
Als	activates	disease	0.65
Fibrosis	inhibits	disease	0.65
Ms	inhibits	disease	0.65
Carcinoma	activates	disease	0.65
Tumor	activates	disease	0.65
Cancer	activates	disease	0.65
Ischemia	inhibits	disease	0.65
Als	regulates	disease	0.65
Stroke	inhibits	disease	0.65
astrocytes	expressed_in	cell_type	0.65
TARDBP	regulates	gene	0.60
ACAT1	regulates	gene	0.60
LGALS1	regulates	gene	0.60
FASN	regulates	gene	0.60
CDK1	regulates	gene	0.60
PTGS1	regulates	gene	0.60
CTSB	regulates	gene	0.60
CTSD	regulates	gene	0.60
SIRT2	activates	gene	0.60
STAT3	activates	gene	0.60
STAT3	phosphorylates	gene	0.60
Neuron	regulates	cell_type	0.60
Mtor	activates	pathway	0.60

Incoming (84)

Source	Relation	Type	Str
h-immunity-c64967ab	relates_to	hypothesis	0.00
h-b701c493b0	targets	hypothesis	1.00
h-b2ebc9b2	targets	hypothesis	1.00
PDCD6	interacts_with	protein	0.95
Retinitis Pigmentosa progression	downregulates	phenotype	0.90
h-2a1a95c1	targets	hypothesis	0.90
h-5afacdfe	targets_gene	hypothesis	0.90
andrographolide	regulates	drug	0.85
EEF2	binds	gene	0.80
PAL	upregulates	compound	0.80
GFAP	regulates	gene	0.70
GLUTAMATE	causes	phenotype	0.70
PKM2	inhibits	gene	0.60
STROKE	inhibits	gene	0.60
HK2	activates	gene	0.60
MTOR	activates	gene	0.60
SRC	activates	gene	0.60
GENES	activates	gene	0.60
HK1	activates	gene	0.60
AMPK	activates	gene	0.60
G6PD	activates	gene	0.60
AKT	activates	gene	0.60
FASN	activates	gene	0.60
LDHB	activates	gene	0.60
MICROGLIA	inhibits	gene	0.60
HK2	inhibits	gene	0.60
IFN	inhibits	gene	0.60
TNF	inhibits	gene	0.60
SPR	inhibits	gene	0.60
TNF-Α	inhibits	gene	0.60
APOPTOSIS	inhibits	gene	0.60
BRAIN INJURY	inhibits	gene	0.60
IL-6	inhibits	gene	0.60
NEUROINFLAMMATION	inhibits	gene	0.60
PKM	activates	gene	0.60
GENES	inhibits	gene	0.60
AKT	inhibits	gene	0.60
MYC	inhibits	gene	0.60
FOXP3	inhibits	gene	0.60
LAG3	inhibits	gene	0.60
RNA	inhibits	gene	0.60
RICTOR	inhibits	gene	0.60
PI3K	inhibits	gene	0.60
GLIOBLASTOMA	associated_with	gene	0.60
GLUT3	activates	gene	0.60
IL-1	inhibits	gene	0.60
GBM	activates	gene	0.60
HIF	activates	gene	0.60
ACC	activates	gene	0.60
ACLY	activates	gene	0.60