protein

GLUT1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GLUT1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

316Connections

0Hypotheses

3Analyses

50Outgoing

50Incoming

Summary

Page for GLUT1 Protein

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🔬 Protein Info

Gene Symbol	GLUT1
Aliases	Glucose Transporter 1
Function	GLUT1 (Glucose Transporter 1), encoded by the SLC2A1 gene, is the primary facilitative glucose transporter at the blood-brain barrier (BBB).
Molecular Weight	54.0 kDa
Pathways	autophagy pathway, blood-brain barrier, Glycolysis, Mtor, Oxidative Phosphorylation
GeneCards	GLUT1
Human Protein Atlas	GLUT1
Associated Diseases	ALS, Bladder Cancer, epilepsy, glioblastoma, multiple sclerosis, neurodegeneration
Known Drugs/Compounds	BAY-876
Interactions	GENES, ENO1, CANCER, E2F1, PDK3, HK2
KG Connections	316 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    GLUT1["<b>GLUT1</b>"]
    triple_negative_breast_cancer{"triple negative breast cancer"}
    GLUT1 -->|"associated with"| triple_negative_breast_cancer
    GLUT1 -->|"biomarker for"| triple_negative_breast_cancer
    PI3K_Akt_Pathway(["PI3K/Akt Pathway"])
    PI3K_Akt_Pathway -->|"phosphorylates"| GLUT1
    SLC2A1["SLC2A1"]
    SLC2A1 -->|"encodes"| GLUT1
    BAY_876["BAY-876"]
    BAY_876 -->|"inhibits"| GLUT1
    RB1["RB1"]
    RB1 -->|"interacts with"| GLUT1
    RB1 -->|"regulates"| GLUT1
    style GLUT1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (237)

Target	Relation	Type	Str
Bladder Cancer	associated_with	disease	0.85
Aerobic Glycolysis	upregulates	process	0.85
Lactate Shuttle	involved_in	mechanism	0.85
High-Carbohydrate Diet	upregulates	drug	0.85
TNF-α	regulates	protein	0.80
Glycolytic Enzymes	regulates	enzyme	0.80
glycolysis	activates	pathway	0.80
triple negative breast cancer	associated_with	disease	0.70
triple negative breast cancer	biomarker_for	disease	0.70
autophagy pathway	participates_in	pathway	0.70
Als	activates	disease	0.65
Cancer	activates	disease	0.65
Tumor	activates	disease	0.65
Metabolic Syndrome	activates	disease	0.65
Carcinoma	activates	disease	0.65
Neurodegeneration	inhibits	disease	0.65
Neurodegeneration	regulates	disease	0.65
Alzheimer	regulates	disease	0.65
Inflammation	regulates	disease	0.65
Ischemia	regulates	disease	0.65
Ms	regulates	disease	0.65
Als	regulates	disease	0.65
ALS	activates	disease	0.65
Glioblastoma	activates	disease	0.65
Cancer	inhibits	disease	0.65
Diabetes	inhibits	disease	0.65
Cancer	regulates	disease	0.65
Glioblastoma	regulates	disease	0.65
Inflammation	inhibits	disease	0.65
Tumor	regulates	disease	0.65
ALS	regulates	disease	0.65
Retinopathy	inhibits	disease	0.65
Retinopathy	activates	disease	0.65
Diabetes	activates	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Alzheimer	protects_against	disease	0.65
Diabetes	protects_against	disease	0.65
Dementia	protects_against	disease	0.65
Neurodegeneration	protects_against	disease	0.65
Als	protects_against	disease	0.65
Neuropathy	protects_against	disease	0.65
OXIDATIVE STRESS	treats	phenotype	0.65
blood-brain barrier	participates_in	pathway	0.65
GENES	activates	gene	0.60
ENO1	activates	gene	0.60
CANCER	activates	gene	0.60
E2F1	activates	gene	0.60
PDK3	activates	gene	0.60
HK2	activates	gene	0.60
PDK1	activates	gene	0.60

Incoming (79)

Source	Relation	Type	Str
PI3K/Akt Pathway	phosphorylates	pathway	0.90
AKT	phosphorylates	protein	0.90
Pi3K/Akt Pathway	phosphorylates	pathway	0.90
PI3K/AKT	phosphorylates	pathway	0.90
WIF1	downregulates	protein	0.85
Akt	phosphorylates	protein	0.80
SLC2A1	encodes	gene	0.70
BAY-876	inhibits	drug	0.70
RB1	interacts_with	protein	0.70
RB1	regulates	protein	0.70
WARBURG EFFECT	phosphorylates	phenotype	0.65
LDHA	activates	gene	0.60
MYC	activates	gene	0.60
AND	activates	gene	0.60
C-MYC	activates	gene	0.60
HIF-1Α	activates	gene	0.60
PI3K	activates	gene	0.60
PFKFB3	activates	gene	0.60
DIABETIC RETINOPATHY	inhibits	gene	0.60
HIF-1Α	inhibits	gene	0.60
HIF-1Α	regulates	gene	0.60
MTORC1	activates	gene	0.60
CANCER	activates	gene	0.60
GSK3	activates	gene	0.60
OXIDATIVE STRESS	inhibits	gene	0.60
MITOCHONDRIA	inhibits	gene	0.60
WIF1	inhibits	gene	0.60
NEURODEGENERATION	inhibits	gene	0.60
WNT	inhibits	gene	0.60
AKT	activates	gene	0.60
PKM	activates	gene	0.60
FASN	activates	gene	0.60
HK1	activates	gene	0.60
HK2	activates	gene	0.60
HIF	activates	gene	0.60
AMPK	activates	gene	0.60
IL-10	activates	gene	0.60
GBM	activates	gene	0.60
LDHB	activates	gene	0.60
GLUT3	activates	gene	0.60
G6PD	activates	gene	0.60
RNA	inhibits	gene	0.60
IL-1	inhibits	gene	0.60
GLUT3	contributes_to	gene	0.60
FLAVONOIDS	inhibits	gene	0.60
SREBP2	regulates	gene	0.60
GBM	associated_with	gene	0.60
RNA	regulates	gene	0.60
EGFR	regulates	gene	0.60
INFLAMMATION	inhibits	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (3)

Scientific analyses that reference this entity

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

neurodegeneration | 2026-04-10 | 0 hypotheses

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

neurodegeneration | 2026-04-10 | 0 hypotheses

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

neurodegeneration | 2026-04-10 | 0 hypotheses

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

GLUT1

Understanding Entity Pages

Summary

Wiki Pages (20)

cbs-psp-daily-action-plan

Energy Metabolism Dysfunction Comparison Across Neurodegenerative Diseases

Blood-Brain Barrier Dysfunction in Neurodegeneration

VEGF/Angiogenesis Pathway in Neurodegeneration

Blood-Brain Barrier Biology and Crossing Strategies

blood-brain-barrier

CREB Signaling in Neurodegeneration

Glia-Neuron Crosstalk in Alzheimer's Disease

metabolic-dysfunction-neurodegeneration

neurovascular-dysfunction

cGMP Signaling Pathway in Neurodegeneration

bbb-transport-mechanisms

Blood-Brain Barrier Breakdown in Neurodegeneration

Type 3 Diabetes Hypothesis of Alzheimer's Disease

GPT - Alanine Transaminase (ALT)

blood-brain-barrier-endothelial-cells

KDM3A Gene (JMJD1A)

Metabolic Dysfunction in Corticobasal Degeneration

Astrocyte Metabolic Enhancement Therapy for PD

Protein O-GlcNAcylation Pathway in Neurodegeneration

Pathway Diagram

Outgoing (237)

Incoming (79)

Targeting Hypotheses (0)

Mentioning Analyses (3)

Do these mechanistic hypotheses from the SEA-AD Atlas bundle explain layer-speci

Do these mechanistic hypotheses explain layer-specific synaptic vulnerability in

Mechanistic validation of SEA-AD differential expression hypotheses: Complement

Related Papers (0)