Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about MARK: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
Knowledge base pages for this entity
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| CSF sTREM2 as Pharmacodynamic Biomarker for Therapeutic Wind | 0.674 | neuroimmunology | What is the temporal sequence of TREM2 s |
| CSF Biomarker-Guided ABCA7 Therapeutic Dosing | 0.619 | neurodegeneration | Why does the V1613M variant reduce amylo |
| Integrated Biomarker Panel for Therapeutic Window Identifica | 0.615 | neurodegeneration | What are the precise temporal dynamics o |
| Lactate/Pyruvate Ratio Dynamics in CSF as a Neuroinflammatio | 0.486 | translational neuroscience | Which metabolic biomarkers can distingui |
| Stage-Specific TREM2 Biomarker-Guided Switching — Agonist in | 0.456 | Alzheimer's disease | TREM2 agonism vs antagonism in DAM micro |
| Mitochondrial Biogenesis Rate as a Dynamic Biomarker of Neur | 0.435 | translational neuroscience | Which metabolic biomarkers can distingui |
Scientific analyses that reference this entity
drug delivery | 2026-04-15 | 0 hypotheses
neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.544
neurodegeneration | 2026-04-14 | 0 hypotheses
neuroinflammation | 2026-04-14 | 0 hypotheses
neurodegeneration | 2026-04-12 | 3 hypotheses Top: 0.700
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Female sex is linked to a stronger association between sTREM2 and CSF p-tau in A [PMID:39794447] | Biel D, Suárez-Calvet M, Dewenter A, Ste | EMBO Mol Med | 2025 | 0 |
| Alterations in mRNA level of proteins related to redox state and mitochondria in [PMID:39529534] | Żulińska S, Wencel PL, Czubowicz K, Stro | Folia Neuropathol | 2024 | 0 |
| Alzheimer's Disease: Models and Molecular Mechanisms Informing Disease and Treat [PMID:38247923] | Nystuen KL, McNamee SM, Akula M, Holton | Bioengineering (Basel) | 2024 | 0 |
| Gene replacement-Alzheimer's disease (GR-AD): Modeling the genetics of human dem [PMID:38343132] | Benzow K, Karanjeet K, Oblak AL, Carter | Alzheimers Dement | 2024 | 0 |
| 2,2',4,4'-Tetrabromodiphenyl ether disrupts spermatogenesis in mice by interferi [PMID:35238255] | Huang S, Xia J, Zhang X, Zhou T, Wang J | Toxicol Ind Health | 2022 | 0 |
| Microglial TYROBP/DAP12 in Alzheimer's disease: Transduction of physiological an [PMID:36002854] | Haure-Mirande JV, Audrain M, Ehrlich ME, | Mol Neurodegener | 2022 | 0 |
| Reactive or transgenic increase in microglial TYROBP reveals a TREM2-independent [PMID:33314529] | Audrain M, Haure-Mirande JV, Mleczko J, | Alzheimers Dement | 2021 | 0 |
| Systematic review of genetic association studies in people with Lewy body dement [PMID:31898332] | Sanghvi H, Singh R, Morrin H, Rajkumar A | Int J Geriatr Psychiatry | 2020 | 0 |
| Glucagon regulates hepatic mitochondrial function and biogenesis through FOXO1. [PMID:31026811] | Yang W, Yan H, Pan Q, Shen JZ, Zhou F et | J Endocrinol | 2019 | 0 |
| Practical considerations for choosing a mouse model of Alzheimer's disease. [PMID:29273078] | Jankowsky JL, Zheng H | Mol Neurodegener | 2017 | 0 |