gene

NFEL

Entity Detail — Knowledge Graph Node

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This page aggregates everything SciDEX knows about NFEL: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

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🧬 Gene Info

Gene Symbol	NFE2L1
Full Name	Nuclear Factor Erythroid 2-Like 1
Chromosome	7q11.23
Protein Type	Transcription Factor
Function	NFE2L1 encodes Nrf1 (Nuclear factor erythroid 2-related factor 1), a transcription factor that regulates antioxidant response and proteasome expression.
Primary Expression	both neurons and glial cells, where it plays essential roles in maintaining redox balance, regulating proteasome function, and coordinating cellular s
Molecular Weight	90 kDa
Amino Acids	742 aa
Pathways	Proteasome Subunit Genes
UniProt ID	[Q14145](https://www.uniprot.org/uniprot/Q14145)
Ensembl ID	ENSG00000118307
OMIM	130120
GeneCards	NFE2L1
Human Protein Atlas	NFE2L1
DNA Binding	Forms heterodimers with small Maf proteins (MAFF, MAFG, MAFK) and binds to Antioxidant Response Elements (ARE) with the consensus sequence 5'-TGACnnnGC-3'
Associated Diseases	Aging, Als, Alzheimer, Neurodegeneration
Interactions	ALZHEIMER, ALZHEIMER'S DISEASE, AMYLOID, AMYLOID-BETA, App, GENES
KG Connections	65 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

NFE2L1 — Nuclear Factor Erythroid 2-Like 1

gene · 1197 words

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Pathway Diagram

graph TD
    NFEL["NFEL"]
    neurodegeneration["neurodegeneration"]
    NFEL -->|"implicated_in"| neurodegeneration
    style NFEL fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
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Related Papers (0)

Scientific publications cited in analyses involving this entity

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Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning NFEL in their description or question text

No additional research found