Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about NOG: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
NOG encodes Noggin, a potent BMP antagonist essential for embryonic development, neurogenesis, and synaptic plasticity. Noggin therapy shows promise for Alzheimer's Disease and Parkinson's Disease.
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| Gene Symbol | NOG |
| Full Name | Noggin |
| Chromosome | 17q22 |
| Function | encodes a secreted polypeptide that functions as a potent BMP antagonist. |
| Primary Expression | the adult brain, where it modulates synaptic plasticity and neuronal survival |
| Amino Acids | 232 aa |
| Exons | 3 |
| UniProt ID | Q15070 |
| NCBI Gene ID | 9241 |
| Ensembl ID | ENSG00000183611 |
| GeneCards | NOG |
| Human Protein Atlas | NOG |
| Signal peptide | N-terminal secretion signal (24 amino acids) |
| Noggin domain | Central region mediating BMP binding |
| Cysteine-rich region | Forms disulfide bonds for stability |
| Associated Diseases | Alzheimer's disease, Parkinson's disease |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
NOG["NOG"]
neurodegeneration["neurodegeneration"]
NOG -->|"implicated_in"| neurodegeneration
style NOG fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| No outgoing edges | |||
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| Plasma D-Dimer Elevation Reflects Fibrinogen Leakage and Sec | 0.685 | - | What blood-brain barrier permeability ch |
| Glycosaminoglycan Template Disruption Approach | 0.597 | neurodegeneration | Protein aggregation cross-seeding across |
| CD300f Immunoglobulin Receptor as Neuroinflammatory Brake | 0.105 | neurodegeneration | Neuroinflammation Biomarker Panel for Ea |
Scientific analyses that reference this entity
No analyses mention this entity
Experimental studies targeting or related to this entity
| Experiment | Type | Disease | Score | Feasibility | Model | Status | Est. Cost |
|---|---|---|---|---|---|---|---|
| E2F coordination of G2/M transcriptional program | exploratory | 0.750 | 0.00 | endocycling mammalian cells | proposed | N/A |
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| Enhancing the efficiency of bone tissue regeneration by using a 3D printed scaff [PMID:41435437] | Ku CY, Chen YH, Lin CM, Chu YH, Ho YJ, L | Biomedical materials (Bristol, | 2026 | 0 |
| Trichomonas vaginalis adhesion protein 65 facilitates human papillomavirus entry [PMID:41199321] | Mei X, Sheng W, Zhang Y, Tian W, Tian X, | Infectious diseases of poverty | 2025 | 0 |
| [WALANT - Wide Awake Local Anaesthesia No Tourniquet: Complications in elective [PMID:35168268] | Wieschollek S, Forster S, Megerle K | Handchirurgie, Mikrochirurgie, | 2022 | 0 |
| Engineering complex communities by directed evolution. [PMID:33986540] | Chang CY, Vila JCC, Bender M, Li R, Mank | Nature ecology & evolution | 2021 | 0 |
| Successful Nonoperative Treatment of Osteochondritis Dissecans of the Humeral Ca [PMID:34825100] | Tajika T, Kuboi T, Endo F, Hatori Y, Sai | Progress in rehabilitation med | 2021 | 0 |
| Combining population genomics and fitness QTLs to identify the genetics of local [PMID:29686078] | Price N, Moyers BT, Lopez L, Lasky JR, M | Proceedings of the National Ac | 2018 | 0 |
| Author Correction: Distinct effects of social motivation on face evaluations in [PMID:30573750] | Safra L, Ioannou C, Amsellem F, Delorme | Scientific reports | 2018 | 0 |
| Midkine is a serum and urinary biomarker for the detection and prognosis of non- [PMID:27974680] | Xia X, Lu JJ, Zhang SS, Su CH, Luo HH | Oncotarget | 2016 | 0 |
| Incidence, Length of Stay, and Prognosis of Hospitalized Patients With Pleural E [PMID:24394842] | Søgaard Mette; Nielsen Rikke B; N&# | Chest | 2014 | 0 |
| Heparan sulfate proteoglycans mediate internalization and propagation of specifi [PMID:23898162] | Holmes BB, DeVos SL, Kfoury N, Li M, Jac | Proceedings of the National Ac | 2013 | 0 |
| Electrophysiological studies in a mouse model of Schwartz-Jampel syndrome demons [PMID:19367640] | ["Echaniz-Laguna A", "Rene F", "Marcel C | Muscle & nerve | 2009 | 0 |
| Angiotensin-converting enzyme degrades Alzheimer amyloid beta-peptide (A beta ); [PMID:11604391] | Hu J, Igarashi A, Kamata M, Nakagawa H | The Journal of biological chem | 2001 | 0 |
Multi-agent debates referencing this entity
No debates reference this entity
Hypotheses and analyses mentioning NOG in their description or question text
No additional research found