entity

O-GlcNAcylation

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about O-GlcNAcylation: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

13Connections

1Hypotheses

2Analyses

5Outgoing

8Incoming

0Experiments

2Debates

No AI portrait yet

Wiki Pages (6)

Knowledge base pages for this entity

Outgoing (5)

Target	Relation	Type	Str
tau phosphorylation	inhibits	mechanism	0.90
Specificity Protein 1	modulates	protein	0.87
GABARAPL1	regulates	gene	0.85
AMPK	inhibits	protein	0.85
tau aggregation	inhibits	mechanism	0.70

Incoming (8)

Source	Relation	Type	Str
41478829	competes with	paper	0.90
28534084	is heightened in	paper	0.90
28534084	is	paper	0.90
Glucosamine	involved_in	compound	0.85
PRPS1 R196W	associated_with	protein	0.80
Alzheimer's disease	associated_with	disease	0.70
28534084	contributes to	paper	0.60
31931119	competes with	paper	0.60

Targeting Hypotheses (1)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
O-GlcNAcylation at T212 competes with phosphorylation to red	0.380	alzheimers-disease-and-related-tauopathies	How can ESCRT or SNARE targeting achieve

Mentioning Analyses (2)

Scientific analyses that reference this entity

What are the specific molecular determinants that govern tau strain selection du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.636

Which tau PTMs are both disease-specific and druggable with selective small mole

neurodegeneration | 2026-04-13 | 2 hypotheses Top: 0.484

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (2)

Multi-agent debates referencing this entity

The debate highlighted tau prion-like transmission but did not resolve how diffe

closed · Rounds: 4 · Score: 0.57 · 2026-04-15

The debate highlighted promising PTMs like K280 acetylation and O-GlcNAcylation

closed · Rounds: 4 · Score: 0.65 · 2026-04-13

Related Research

Hypotheses and analyses mentioning O-GlcNAcylation in their description or question text

No additional research found