Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about TAU PHOSPHORYLATION: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | TAU PHOSPHORYLATION |
| Key Genes/Proteins | SNAP25, TAU, TREM2, MAPK |
| Related Diseases | AUTOPHAGY, NEURODEGENERATION, DEMENTIA, ACETYLCHOLINE |
| Related Pathways | WNT PATHWAY |
Knowledge base pages for this entity
graph TD
TAU_PHOSPHORYLATION["TAU PHOSPHORYLATION"]
TAU_PHOSPHORYLATION -.biomarker for.-> Down_syndrome["Down syndrome"]
TAU_PHOSPHORYLATION -.biomarker for.-> Alzheimer_s_disease["Alzheimer's disease"]
Glucocorticoid_Receptor["Glucocorticoid Receptor"] -->|"regulates"| TAU_PHOSPHORYLATION
Amyloid__["Amyloid-beta"] -->|"activates"| TAU_PHOSPHORYLATION
phytochemicals["phytochemicals"] -->|"regulates"| TAU_PHOSPHORYLATION
p38_MAPK["p38 MAPK"] -->|"activates"| TAU_PHOSPHORYLATION
A_["Abeta"] -->|"activates"| TAU_PHOSPHORYLATION
NPTX2["NPTX2"] -->|"target for"| TAU_PHOSPHORYLATION
WIF1["WIF1"] -->|"target for"| TAU_PHOSPHORYLATION
AMYLOID["AMYLOID"] -->|"regulates"| TAU_PHOSPHORYLATION
ALZHEIMER_S_DISEASE["ALZHEIMER'S DISEASE"] -->|"expressed in"| TAU_PHOSPHORYLATION
AMYLOID___PLAQUES["AMYLOID-Beta PLAQUES"] -->|"expressed in"| TAU_PHOSPHORYLATION| Target | Relation | Type | Str |
|---|---|---|---|
| SNAP25 | activates | gene | 0.70 |
| AUTOPHAGY | activates | phenotype | 0.70 |
| WNT PATHWAY | regulates | pathway | 0.65 |
| AUTOPHAGY | phosphorylates | phenotype | 0.65 |
| MAPK | inhibits | gene | 0.65 |
| ACETYLCHOLINE | regulates | phenotype | 0.65 |
| NEURONS | interacts_with | cell_type | 0.65 |
| PREFRONTAL CORTEX | associated_with | brain_region | 0.50 |
| AMYGDALA | associated_with | brain_region | 0.50 |
| INSULIN SIGNALING | associated_with | pathway | 0.50 |
| LITHIUM | associated_with | drug | 0.50 |
| EMPAGLIFLOZIN | associated_with | drug | 0.50 |
| VISUAL CORTEX | associated_with | brain_region | 0.50 |
| MEMANTINE | associated_with | drug | 0.45 |
| CORTEX | associated_with | brain_region | 0.45 |
| NLRP3 INFLAMMASOME | associated_with | pathway | 0.45 |
| HIPPOCAMPUS | associated_with | brain_region | 0.45 |
| WNT PATHWAY | associated_with | pathway | 0.45 |
| WNT SIGNALING | associated_with | pathway | 0.45 |
| DAPAGLIFLOZIN | associated_with | drug | 0.45 |
| ENTORHINAL CORTEX | associated_with | brain_region | 0.45 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NEURODEGENERATION | inhibits | phenotype | 0.70 |
| TAU | causes | protein | 0.70 |
| NEURONS | produces | cell_type | 0.70 |
| NEURONS | treats | cell_type | 0.70 |
| DEMENTIA | protects_against | disease | 0.70 |
| DEMENTIA | inhibits | disease | 0.70 |
| TREM2 | treats | gene | 0.70 |
| MAPK | causes | gene | 0.65 |
| PINK1 | activates | gene | 0.65 |
| PINK1 | inhibits | gene | 0.65 |
| CORTEX | activates | brain_region | 0.65 |
| GABA | regulates | phenotype | 0.65 |
| CDK5 | regulates | gene | 0.65 |
| JAK2 | inhibits | gene | 0.65 |
| CDK5 | targets | gene | 0.65 |
| CERAMIDE | causes | phenotype | 0.65 |
| APOE | regulates | gene | 0.65 |
| NGF | regulates | gene | 0.65 |
| GLUT4 | transports | gene | 0.60 |
| ALZHEIMER'S DISEASE | implicated_in | disease | 0.55 |
| BDNF | associated_with | gene | 0.50 |
| MEMANTINE | associated_with | drug | 0.45 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||