gene

GABARAPL1

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about GABARAPL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

238Connections
0Hypotheses
0Analyses
50Outgoing
50Incoming

Summary

GABARAPL1 encodes a member of the ATG8 family of autophagy proteins involved in autophagosome formation, selective autophagy, and neurodegeneration

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🧬 Gene Info
Gene SymbolGABARAPL1
Full NameGABA Type A Receptor Associated Protein Like 1
Chromosome12p13.2
Functionis a gene located on chromosome 12p13.
Primary Expressionthe brain and plays essential roles in autophagy, intracellular trafficking, and cellular stress responses[@legrand2021]
Molecular Weight14 kDa
Amino Acids117 aa
PathwaysGlycophagy
UniProt IDQ9Y4L5
NCBI Gene ID23710
Ensembl IDENSG00000139218
OMIM607420
GeneCardsGABARAPL1
Human Protein AtlasGABARAPL1
Brain (cortex, hippocampus, cerebellum)High
Associated DiseasesALS, Cancer, Ms, Tumor
Known Drugs/Compoundsrapamycin
InteractionsRB1CC1, ATG12, SIRT1, AKT, PI3K, GABARAP
KG Connections238 knowledge graph edges
DatabasesGeneCardsHPASTRING
🔮 Predicted Structure: GABARAPL1 — AlphaFold Q9Y4L5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (21)

Knowledge base pages for this entity

Canonical Page

GABARAPL1 — GABA Type A Receptor Associated Protein Like 1

gene · 816 words

Melatonin for Tauopathy: Comprehensive Evidence Synthesis

therapeutic · 4539 words

MAP1LC3A Gene

gene · 3023 words

RETREG3 (Reticulophagy Regulator 3)

gene · 2881 words

ATG7 Protein — Autophagy-Related Protein 7

protein · 2396 words

CBS Autophagy-Lysosomal Pathway Dysfunction

mechanism · 2260 words

Pathway Diagram

graph TD
    GABARAPL1["<b>GABARAPL1</b>"]
    Ms{"Ms"}
    GABARAPL1 -->|"associated with"| Ms
    Als{"Als"}
    GABARAPL1 -->|"associated with"| Als
    GABARAPL1 -->|"biomarker for"| Als
    Autism{"Autism"}
    GABARAPL1 -->|"biomarker for"| Autism
    GABARAPL1 -->|"biomarker for"| Ms
    Cancer{"Cancer"}
    GABARAPL1 -->|"associated with"| Cancer
    Tumor{"Tumor"}
    GABARAPL1 -->|"associated with"| Tumor
    ALS{"ALS"}
    GABARAPL1 -->|"associated with"| ALS
    MAP1LC3B["MAP1LC3B"]
    GABARAPL1 -->|"associated with"| MAP1LC3B
    RB1["RB1"]
    GABARAPL1 -->|"associated with"| RB1
    PRKN["PRKN"]
    GABARAPL1 -->|"associated with"| PRKN
    RB1CC1["RB1CC1"]
    GABARAPL1 -->|"associated with"| RB1CC1
    GABARAP["GABARAP"]
    GABARAP -->|"associated with"| GABARAPL1
    VAMP8["VAMP8"]
    VAMP8 -->|"associated with"| GABARAPL1
    RTN3["RTN3"]
    RTN3 -->|"associated with"| GABARAPL1
    LAMP2["LAMP2"]
    LAMP2 -->|"associated with"| GABARAPL1
    DNM1L["DNM1L"]
    DNM1L -->|"associated with"| GABARAPL1
    ULK1["ULK1"]
    ULK1 -->|"associated with"| GABARAPL1
    LC3["LC3"]
    LC3 -->|"associated with"| GABARAPL1
    MTOR["MTOR"]
    MTOR -->|"associated with"| GABARAPL1
    RAB2A["RAB2A"]
    RAB2A -->|"associated with"| GABARAPL1
    VAMP7["VAMP7"]
    VAMP7 -->|"associated with"| GABARAPL1
    STX17["STX17"]
    STX17 -->|"associated with"| GABARAPL1
    RAB7A["RAB7A"]
    RAB7A -->|"associated with"| GABARAPL1
    style GABARAPL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0

Outgoing (157)

TargetRelationTypeStr
Glycophagymediatesprocess0.95
Glycophagyinvolved_inprocess0.95
Glycophagyregulatesprocess0.95
Ischemic Stroke Reperfusion Injuryprotects_againstdisease0.90
DNA Damageprotects_againstphenotype0.85

Incoming (81)

SourceRelationTypeStr
STBD1interacts_withprotein0.95
STBD1bindsprotein0.93
PI3K-AKT Pathwaydownregulatespathway0.90
PI3K-AKTdownregulatespathway0.90
PI3K-Akt Pathwaydownregulatespathway0.88

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

HypothesisScoreDiseaseAnalysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMIDAuthorsJournalYearCitations
No papers found