Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about GABARAPL1: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
GABARAPL1 encodes a member of the ATG8 family of autophagy proteins involved in autophagosome formation, selective autophagy, and neurodegeneration
| Gene Symbol | GABARAPL1 |
| Full Name | GABA Type A Receptor Associated Protein Like 1 |
| Chromosome | 12p13.2 |
| Function | is a gene located on chromosome 12p13. |
| Primary Expression | the brain and plays essential roles in autophagy, intracellular trafficking, and cellular stress responses[@legrand2021] |
| Molecular Weight | 14 kDa |
| Amino Acids | 117 aa |
| Pathways | Glycophagy |
| UniProt ID | Q9Y4L5 |
| NCBI Gene ID | 23710 |
| Ensembl ID | ENSG00000139218 |
| OMIM | 607420 |
| GeneCards | GABARAPL1 |
| Human Protein Atlas | GABARAPL1 |
| Brain (cortex, hippocampus, cerebellum) | High |
| Associated Diseases | ALS, Cancer, Ms, Tumor |
| Known Drugs/Compounds | rapamycin |
| Interactions | RB1CC1, ATG12, SIRT1, AKT, PI3K, GABARAP |
| KG Connections | 238 knowledge graph edges |
| Databases | GeneCardsHPASTRING |
Knowledge base pages for this entity
graph TD
GABARAPL1["<b>GABARAPL1</b>"]
Ms{"Ms"}
GABARAPL1 -->|"associated with"| Ms
Als{"Als"}
GABARAPL1 -->|"associated with"| Als
GABARAPL1 -->|"biomarker for"| Als
Autism{"Autism"}
GABARAPL1 -->|"biomarker for"| Autism
GABARAPL1 -->|"biomarker for"| Ms
Cancer{"Cancer"}
GABARAPL1 -->|"associated with"| Cancer
Tumor{"Tumor"}
GABARAPL1 -->|"associated with"| Tumor
ALS{"ALS"}
GABARAPL1 -->|"associated with"| ALS
MAP1LC3B["MAP1LC3B"]
GABARAPL1 -->|"associated with"| MAP1LC3B
RB1["RB1"]
GABARAPL1 -->|"associated with"| RB1
PRKN["PRKN"]
GABARAPL1 -->|"associated with"| PRKN
RB1CC1["RB1CC1"]
GABARAPL1 -->|"associated with"| RB1CC1
GABARAP["GABARAP"]
GABARAP -->|"associated with"| GABARAPL1
VAMP8["VAMP8"]
VAMP8 -->|"associated with"| GABARAPL1
RTN3["RTN3"]
RTN3 -->|"associated with"| GABARAPL1
LAMP2["LAMP2"]
LAMP2 -->|"associated with"| GABARAPL1
DNM1L["DNM1L"]
DNM1L -->|"associated with"| GABARAPL1
ULK1["ULK1"]
ULK1 -->|"associated with"| GABARAPL1
LC3["LC3"]
LC3 -->|"associated with"| GABARAPL1
MTOR["MTOR"]
MTOR -->|"associated with"| GABARAPL1
RAB2A["RAB2A"]
RAB2A -->|"associated with"| GABARAPL1
VAMP7["VAMP7"]
VAMP7 -->|"associated with"| GABARAPL1
STX17["STX17"]
STX17 -->|"associated with"| GABARAPL1
RAB7A["RAB7A"]
RAB7A -->|"associated with"| GABARAPL1
style GABARAPL1 fill:#1a3a4a,stroke:#4fc3f7,stroke-width:3px,color:#e0e0e0| Target | Relation | Type | Str |
|---|---|---|---|
| Glycophagy | mediates | process | 0.95 |
| Glycophagy | involved_in | process | 0.95 |
| Glycophagy | regulates | process | 0.95 |
| Ischemic Stroke Reperfusion Injury | protects_against | disease | 0.90 |
| DNA Damage | protects_against | phenotype | 0.85 |
| Oxidative Injury | protects_against | phenotype | 0.85 |
| GABARAPL2 | associated_with | gene | 0.70 |
| GABARAP | associated_with | gene | 0.70 |
| Ms | associated_with | disease | 0.65 |
| Als | associated_with | disease | 0.65 |
| Als | biomarker_for | disease | 0.65 |
| Autism | biomarker_for | disease | 0.65 |
| Ms | biomarker_for | disease | 0.65 |
| Cancer | associated_with | disease | 0.65 |
| Tumor | associated_with | disease | 0.65 |
| ALS | associated_with | disease | 0.65 |
| Als | implicated_in | disease | 0.65 |
| Als | interacts_with | disease | 0.65 |
| Ms | activates | disease | 0.65 |
| Als | activates | disease | 0.65 |
| Stroke | inhibits | disease | 0.65 |
| ALS | interacts_with | disease | 0.65 |
| MAP1LC3B | associated_with | gene | 0.60 |
| RB1 | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| RB1CC1 | associated_with | gene | 0.60 |
| RAB2A | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| RTN3 | associated_with | gene | 0.60 |
| LC3 | associated_with | gene | 0.60 |
| GABRB1 | expressed_in | gene | 0.60 |
| GABARAP | expressed_in | gene | 0.60 |
| GABARAP | regulates | gene | 0.60 |
| CALCOCO2 | associated_with | gene | 0.60 |
| FOXO3 | associated_with | gene | 0.60 |
| BNIP3L | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| VAMP7 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| DNM1L | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| LAMP2 | activates | entity | 0.60 |
| MAP1LC3B | activates | entity | 0.60 |
| MTOR | activates | entity | 0.60 |
| PRKN | activates | entity | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| STBD1 | interacts_with | protein | 0.95 |
| STBD1 | binds | protein | 0.93 |
| PI3K-AKT Pathway | downregulates | pathway | 0.90 |
| PI3K-AKT | downregulates | pathway | 0.90 |
| PI3K-Akt Pathway | downregulates | pathway | 0.88 |
| O-GlcNAcylation | regulates | process | 0.85 |
| Specificity Protein 1 | regulates | protein | 0.84 |
| PI3K/Akt pathway | downregulates | pathway | 0.80 |
| ASTROCYTE | regulates | cell_type | 0.80 |
| ASTROCYTES | regulates | cell_type | 0.80 |
| LC3 | associated_with | gene | 0.70 |
| GABARAP | associated_with | gene | 0.60 |
| VAMP8 | associated_with | gene | 0.60 |
| RTN3 | associated_with | gene | 0.60 |
| LAMP2 | associated_with | gene | 0.60 |
| DNM1L | associated_with | gene | 0.60 |
| ULK1 | associated_with | gene | 0.60 |
| MTOR | associated_with | gene | 0.60 |
| RAB2A | associated_with | gene | 0.60 |
| VAMP7 | associated_with | gene | 0.60 |
| STX17 | associated_with | gene | 0.60 |
| RAB7A | associated_with | gene | 0.60 |
| SNAP29 | associated_with | gene | 0.60 |
| MAP1LC3B | associated_with | gene | 0.60 |
| PRKN | associated_with | gene | 0.60 |
| RB1 | associated_with | gene | 0.60 |
| RB1CC1 | associated_with | gene | 0.60 |
| BNIP3 | associated_with | gene | 0.60 |
| UBIQUITIN | associated_with | gene | 0.60 |
| LC3 | interacts_with | gene | 0.60 |
| DNM1L | activates | entity | 0.60 |
| GABARAP | activates | entity | 0.60 |
| FOXO1 | activates | gene | 0.60 |
| RB1CC1 | interacts_with | gene | 0.60 |
| AKT | activates | gene | 0.60 |
| PI3K | activates | gene | 0.60 |
| CHOP | inhibits | gene | 0.60 |
| GAA | inhibits | gene | 0.60 |
| GABARAP | regulates | gene | 0.60 |
| GABARAP | interacts_with | gene | 0.60 |
| ATG16L1 | activates | gene | 0.60 |
| CALCOCO2 | activates | gene | 0.60 |
| FIP200 | activates | gene | 0.60 |
| ATG | associated_with | gene | 0.60 |
| LYSOSOME | associated_with | gene | 0.60 |
| MITOPHAGY | associated_with | gene | 0.60 |
| ATG8 | associated_with | gene | 0.60 |
| LC3B | associated_with | gene | 0.60 |
| AUTOPHAGY | implicated_in | gene | 0.60 |
| AND | interacts_with | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||