concept

PI3K-AKT PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PI3K-AKT PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

18Connections

0Hypotheses

1Analyses

10Outgoing

8Incoming

0Experiments

1Debates

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💡 Concept Info

Name	PI3K-AKT PATHWAY

Pathway Diagram

graph TD
    PI3K_AKT_PATHWAY[PI3K-AKT PATHWAY]
    PI3K_AKT_PATHWAY -->|promotes| breast_cancer[breast cancer]
    PI3K_AKT_PATHWAY -->|downregulates| GABARAPL1[GABARAPL1]
    PI3K_AKT_PATHWAY -->|regulates| Lysosomal_Synapses[Lysosomal Synapses]
    PI3K_AKT_PATHWAY -->|interacts| mTOR_pathway[mTOR pathway]
    PI3K_AKT_PATHWAY -->|promotes| peripheral_nerve_repair[peripheral nerve repair]
    PI3K_AKT_PATHWAY -->|activates| Vascular_Niche_Formation[Vascular Niche Formation]
    PI3K_AKT_PATHWAY -->|regulates| lysosome_exocytosis[lysosome exocytosis]
    PI3K_AKT_PATHWAY -->|regulates| actin_polymerization[actin polymerization]
    LARS2[LARS2] -->|modulates| PI3K_AKT_PATHWAY
    Andrographis_paniculata[Andrographis paniculata] -->|inhibits| PI3K_AKT_PATHWAY
    PIEZO1[PIEZO1] -->|activates| PI3K_AKT_PATHWAY
    ASTROCYTE[ASTROCYTE] -->|regulates| PI3K_AKT_PATHWAY
    ASTROCYTES[ASTROCYTES] -->|regulates| PI3K_AKT_PATHWAY
    AKT[AKT] -->|part_of| PI3K_AKT_PATHWAY
    PFOS[PFOS] -->|disrupts| PI3K_AKT_PATHWAY

Outgoing (10)

Target	Relation	Type	Str
breast cancer	promotes	disease	0.95
GABARAPL1	downregulates	gene	0.90
microglial survival/proliferation	protective_against	phenotype	0.90
GABARAPL1	downregulates	gene	0.88
Lysosomal Synapses	regulates	process	0.85
peripheral nerve repair	promotes	process	0.85
Vascular Niche Formation	activates	process	0.85
mTOR pathway	interacts_with	pathway	0.85
lysosome exocytosis	regulates	process	0.70
actin polymerization	regulates	process	0.70

Incoming (8)

Source	Relation	Type	Str
TREM2	activates	protein	0.90
LARS2	modulates	gene	0.85
Andrographis paniculata	inhibits	drug	0.80
PIEZO1	activates	protein	0.80
AKT	part_of	gene	0.70
ASTROCYTE	regulates	cell_type	0.70
ASTROCYTES	regulates	cell_type	0.70
PFOS	disrupts	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Can biased TREM2 agonists selectively activate DAP12-SYK-PI3K without triggering

molecular biology | 2026-04-12 | 0 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The theorist proposed this novel approach to enable safe agonism across disease

closed · Rounds: 4 · Score: 0.50 · 2026-04-18

Related Research

Hypotheses and analyses mentioning PI3K-AKT PATHWAY in their description or question text

No additional research found