concept

MTOR PATHWAY

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about MTOR PATHWAY: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

212Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

No summary available yet. View on Wiki →

💡 Concept Info

Name	MTOR PATHWAY
Key Genes/Proteins	PIK3CA, LAMP1, PPARGC1A, RAB7A, APOE
Related Diseases	CELL DEATH, AGING, BREAST CANCER, AUTOPHAGY, INFLAMMATION

Wiki Pages (20)

Knowledge base pages for this entity

Pathway Diagram

graph TD
    MTOR_PATHWAY["MTOR PATHWAY"]
    MTOR_PATHWAY -->|"inhibits"| autophagy["autophagy"]
    MTOR_PATHWAY -->|"mediates"| Offspring_Stem_Cell_Programmin["Offspring Stem Cell Programming"]
    MTOR_PATHWAY -->|"activates"| Vascular_Niche_Formation["Vascular Niche Formation"]
    MTOR_PATHWAY -->|"regulates"| Autophagy["Autophagy"]
    MTOR_PATHWAY -->|"causes"| epilepsy["epilepsy"]
    MTOR_PATHWAY -->|"contributes to"| neuronal_excitability["neuronal excitability"]
    MTOR_PATHWAY -->|"involved_in"| Salidroside_Induced_Cell_Death["Salidroside-Induced Cell Death"]
    AKT["AKT"] -->|"upstream_of"| MTOR_PATHWAY
    Lyso_ChR2["Lyso-ChR2"] -->|"activates"| MTOR_PATHWAY
    PI3K_AKT_pathway["PI3K-AKT pathway"] -->|"interacts"| MTOR_PATHWAY
    Hearing_Loss["Hearing Loss"] -->|"activates"| MTOR_PATHWAY
    Short_Chain_Fatty_Acids["Short-Chain Fatty Acids"] -->|"activates"| MTOR_PATHWAY
    Ferroptosis["Ferroptosis"] -->|"involved_in"| MTOR_PATHWAY
    MTOR["MTOR"] -->|"activates"| MTOR_PATHWAY
    CANCER["CANCER"] -->|"activates"| MTOR_PATHWAY

Outgoing (78)

Target	Relation	Type	Str
CELL DEATH	activates	phenotype	0.65
PIK3CA	regulates	gene	0.65
AGING	treats	phenotype	0.65
BREAST CANCER	inhibits	disease	0.65
AUTOPHAGY	treats	phenotype	0.65
AGING	regulates	phenotype	0.65
INFLAMMATION	regulates	phenotype	0.65
AGING	targets	phenotype	0.65
REMYELINATION	implicated_in	phenotype	0.55
TNF	associated_with	gene	0.50
HK2	associated_with	gene	0.50
MITOPHAGY	associated_with	phenotype	0.50
AMYLOID	associated_with	protein	0.50
PARKIN	associated_with	gene	0.50
TREM2	associated_with	gene	0.50
PINK1	associated_with	gene	0.50
APOE	associated_with	gene	0.50
TFEB	associated_with	gene	0.50
LDLR	associated_with	gene	0.50
APP	associated_with	gene	0.50
TAU	associated_with	protein	0.50
MACROPHAGE	associated_with	cell_type	0.45
MICROGLIA	associated_with	cell_type	0.45
ISCHEMIA	associated_with	disease	0.45
AMPK	associated_with	gene	0.45
PTEN	associated_with	gene	0.45
LUNG CANCER	associated_with	disease	0.45
APOPTOSIS	associated_with	phenotype	0.45
AGING	associated_with	phenotype	0.45
ROS	associated_with	phenotype	0.45
CELL DEATH	associated_with	phenotype	0.45
SLC7A11	associated_with	gene	0.45
GPX4	associated_with	gene	0.45
PIK3CA	associated_with	gene	0.45
STEM CELLS	associated_with	cell_type	0.45
AUTOPHAGY	associated_with	phenotype	0.45
CYTOKINES	associated_with	phenotype	0.45
FIBROSIS	associated_with	disease	0.45
SNAP25	associated_with	gene	0.45
FIBROBLASTS	associated_with	cell_type	0.45
TSC1	associated_with	gene	0.45
TSC2	associated_with	gene	0.45
RHEB	associated_with	gene	0.45
PSORIASIS	associated_with	disease	0.45
IDH1	associated_with	gene	0.45
DIABETES	associated_with	disease	0.45
OBESITY	associated_with	disease	0.45
EGFR	associated_with	gene	0.45
GLYCOLYSIS	associated_with	phenotype	0.45
BAICALEIN	associated_with	drug	0.45

Incoming (134)

Source	Relation	Type	Str
CANCER	targets	disease	0.65
RAPAMYCIN	treats	drug	0.65
LAMP1	activates	gene	0.55
PPARGC1A	activates	gene	0.55
RAB7A	activates	gene	0.55
APOE	inhibits	gene	0.55
P2RY12	inhibits	gene	0.55
STING1	activates	gene	0.55
MCOLN1	activates	gene	0.55
TARDBP	activates	gene	0.55
HK2	transports	gene	0.55
G3BP1	involved_in	gene	0.55
G3BP1	expression	gene	0.55
STX17	activates	gene	0.55
ULK1	activates	gene	0.55
LAMP1	interacts_with	gene	0.55
MCOLN1	interacts_with	gene	0.55
STX17	interacts_with	gene	0.55
ULK1	interacts_with	gene	0.55
CHMP2B	activates	gene	0.55
VCP	activates	gene	0.55
SNAP25	activates	gene	0.55
TUBB3	activates	gene	0.55
TFRC	involved_in	gene	0.55
BCL2L1	activates	gene	0.55
DNMT1	activates	gene	0.55
SETX	activates	gene	0.55
APOE	involved_in	gene	0.55
ULK1	involved_in	gene	0.55
ULK1	inhibits	gene	0.55
MMP9	inhibits	gene	0.55
STING1	interacts_with	gene	0.55
STING1	involved_in	gene	0.55
STING1	regulates	gene	0.55
C1Q	activates	gene	0.55
FOXO1	activates	gene	0.55
GLP1R	activates	gene	0.55
PLIN2	activates	gene	0.55
SIRT3	activates	gene	0.55
SREBF2	activates	gene	0.55
CHR2	activates	gene	0.55
BDNF	interacts_with	gene	0.55
SNAP25	inhibits	gene	0.55
ACSL4	modifies	gene	0.55
GPX4	modifies	gene	0.55
SLC7A11	modifies	gene	0.55
BDNF	activates	gene	0.55
TFAM	inhibits	gene	0.55
HSP90AA1	involved_in	gene	0.55
FOXP3	involved_in	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

MTOR PATHWAY

Understanding Entity Pages

Wiki Pages (20)

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Wnt Non-Canonical Signaling Pathways in Neurodegeneration

Rapamycin ALS Trial - mTOR Inhibition for Amyotrophic Lateral Sclerosis

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LRRK2 Kinase Activation and Endolysosomal Dysfunction in Parkinson's Disease

Neuroprotection Strategies in Neurodegeneration

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RPL30 — Ribosomal Protein L30 in Neurodegeneration

RNA Metabolism Dysregulation in Alzheimer's Disease

IGF-1 Signaling Pathway in Neurodegeneration

Cellular Senescence in Neurodegeneration

NF-κB Signaling Pathway in Neurodegeneration

autophagy-lysosomal-alzheimers

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Proteostasis Network Dysfunction Comparison Across Neurodegenerative Diseases