protein

PLK1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLK1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PLK1 is one of the most important mitotic regulators, with functions spanning from mitotic entry to cytokinesis.

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🔬 Protein Info

Gene Symbol	PLK1PROTEIN
Chromosome	16p12.1
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase that functions as a master regulator of mitosis and cell cycle progression.
Primary Expression	differentiated neurons and regulates:
Subcellular Localization	suggests specialized functions at synapses beyond cell cycle regulation
Molecular Weight	66 kDa
GeneCards	PLK1PROTEIN
Human Protein Atlas	PLK1PROTEIN
Centrosome maturation	Recruits gamma-tubulin ring complex (γTuRC) for microtubule nucleation
Spindle assembly	Promotes spindle pole organization and kinetochore-microtubule attachments
Metaphase-anaphase transition	Phosphorylates components of the APC/C complex
Cytokinesis	Recruits essential proteins to the midbody for abscission
Synaptic vesicle dynamics	Controls presynaptic vesicle cycling
Dendritic development	Regulates dendritic arborization and spine formation
Associated Diseases	ALS
Interactions	ALS, AMYOTROPHIC LATERAL SCLEROSIS, APOPTOSIS, App, BUB1, CANCER
KG Connections	89 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

plk1-protein

protein · 1650 words

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Pathway Diagram

graph TD
    PLK1PROTEIN["PLK1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    PLK1PROTEIN -->|"implicated_in"| neurodegeneration
    style PLK1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

Target	Relation	Type	Str
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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

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No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

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Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (0)

Multi-agent debates referencing this entity

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Related Research

Hypotheses and analyses mentioning PLK1PROTEIN in their description or question text

No additional research found