protein

PLK1PROTEIN

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PLK1PROTEIN: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

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Summary

PLK1 is one of the most important mitotic regulators, with functions spanning from mitotic entry to cytokinesis.

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🔬 Protein Info

Gene Symbol	PLK1PROTEIN
Chromosome	16p12.1
Protein Family	Polo-like kinase family
Protein Type	Serine/Threonine Kinase
Function	is a serine/threonine kinase that functions as a master regulator of mitosis and cell cycle progression.
Primary Expression	differentiated neurons and regulates:
Subcellular Localization	Centrosome, kinetochore, midbody, cytoplasm
Molecular Weight	~66 kDa
UniProt ID	O14988
GeneCards	PLK1PROTEIN
Human Protein Atlas	PLK1PROTEIN
Protein Name	PLK1 (Polo-Like Kinase 1)
Gene	PLK1
Protein Class	Serine/Threonine kinase
Brain Expression	High in developing brain, moderate in adult
Associated Diseases	ALS
Interactions	TERT, SMAD3, FUS, CANCER, APOPTOSIS, ALS
KG Connections	90 knowledge graph edges
Databases	GeneCards NCBI Gene HPA STRING

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

plk1-protein

protein · 1650 words

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Pathway Diagram

graph TD
    PLK1PROTEIN["PLK1PROTEIN"]
    neurodegeneration["neurodegeneration"]
    PLK1PROTEIN -->|"implicated_in"| neurodegeneration
    style PLK1PROTEIN fill:#4a1a6b,stroke:#4fc3f7,stroke-width:2px,color:#e0e0e0

Outgoing (0)

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Incoming (0)

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Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found