Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about PPP3CA: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
| Gene Symbol | PPP3CA |
| Aliases | Calcineurin |
| Chromosome | 4p16.3 |
| Protein Type | Phosphatase |
| Function | is a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979]. |
| Primary Expression | a tissue-specific manner: |
| Molecular Weight | 59 kDa |
| Amino Acids | 521 aa |
| Exons | 14 |
| GeneCards | PPP3CA |
| Human Protein Atlas | PPP3CA |
| NFAT (Nuclear Factor of Activated T-cells) | Gene transcription |
| Synapsin I | Vesicle trafficking |
| AMPA receptor subunits | Receptor trafficking |
| DARPP-32 | Dopamine signaling |
| Associated Diseases | Axon Repulsion, neurodegeneration |
| Interactions | NLRP3 |
| KG Connections | 4 knowledge graph edges |
| Databases | GeneCardsUniProtNCBI GeneHPASTRING |
Knowledge base pages for this entity
flowchart TD
PPP3CA(["PPP3CA"])
Growth_Cone_Turning("Growth Cone Turning")
Axon_Repulsion("Axon Repulsion")
Calcium["Calcium"]
CAMK2A["CAMK2A"]
cAMP["cAMP"]
neurodegeneration["neurodegeneration"]
PPP3CA -->|"mediates"| Growth_Cone_Turning
PPP3CA -->|"associated with"| Axon_Repulsion
Calcium -->|"activates"| PPP3CA
CAMK2A -->|"interacts with"| PPP3CA
cAMP -.->|"inhibits"| PPP3CA
PPP3CA -->|"implicated in"| neurodegeneration
style PPP3CA fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff| Target | Relation | Type | Str |
|---|---|---|---|
| neuroinflammation | activates | disease | 0.60 |
| pyroptosis | participates_in | pathway | 0.60 |
| microglia | expressed_in | cell_type | 0.55 |
| Source | Relation | Type | Str |
|---|---|---|---|
| NLRP3 | activates | gene | 0.60 |
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||