gene 1,663 words KG: CALCINEURIN 2026-03-28
kind:genesection:genesstate:published
Contents

PPP3CA — Protein Phosphatase 3 Catalytic Subunit Alpha

🧬 Gene Info
Gene SymbolPPP3CA
Full NameProtein Phosphatase 3 Catalytic Subunit Alpha (Calcineurin)
AliasesCalcineurin
Chromosome4p16.3
Protein TypePhosphatase
Functionis a unique calcium/calmodulin-dependent phosphatase that plays critical roles in neuronal signal transduction, synaptic plasticity, gene transcription, and immune cell activation[@klee1979].
Primary Expressiona tissue-specific manner:
Molecular Weight59 kDa
Amino Acids521 aa
Exons14
GeneCardsPPP3CA
Human Protein AtlasPPP3CA
Associated DiseasesAxon Repulsion, neurodegeneration
InteractionsNLRP3
KG Connections4 knowledge graph edges
DatabasesGeneCardsUniProtNCBI GeneHPASTRING

Knowledge Graph

Related Hypotheses (30)

Nutrient-Sensing Epigenetic Circuit Reactivation
Score: 0.67
Transcriptional Autophagy-Lysosome Coupling
Score: 0.66
Digital Twin-Guided Metabolic Reprogramming
Score: 0.61
Senescent Cell Mitochondrial DNA Release
Score: 0.54
Near-infrared light therapy stimulates COX4-dependent mitoch
Score: 0.51

Related Analyses (15)

TDP-43 phase separation therapeutics for ALS-FTD
neurodegeneration · archived
Astrocyte reactivity subtypes in neurodegeneration
neurodegeneration · archived
Microglia-astrocyte crosstalk amplification loops in neurode
neurodegeneration · archived
Autophagy-lysosome pathway convergence across neurodegenerat
neurodegeneration · archived
Synaptic pruning by microglia in early AD
neurodegeneration · archived

Related Experiments (1)

Gap Junction Dysfunction Validation in Parkinson's Disease
clinical · proposed · Score: 0.40

See Also (10)

Apoptosis Pathway in Neurodegeneration
mechanism · KG edge: expressed_in
Packard Center for ALS Research
institution · KG edge: activates
Alzheimer Indonesia
institution · KG edge: expressed_in
AQP4 (Aquaporin-4 Gene)
gene · KG edge: activates
ANG — Angiogenin
gene · KG edge: associated_with

Knowledge Graph (12 edges)

CALCINEURIN phosphorylates TFEB
CALCINEURIN activates ATG12
CALCINEURIN activates STUB1
CALCINEURIN activates PPARGC1A
CALCINEURIN activates TARDBP
CALCINEURIN activates TREH
CALCINEURIN activates BECN1
CALCINEURIN activates GAPDH
CALCINEURIN activates PPP3CB
CALCINEURIN activates HSPB8