protein

PTPRC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about PTPRC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

0Analyses

0Outgoing

8Incoming

Summary

PTPRC (CD45) is a receptor-type protein tyrosine phosphatase critical for immune cell signaling and microglial function in neurodegeneration. This page covers its structure, function in the brain, and role in Alzheimer's and Parkinson's diseases.

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🔬 Protein Info

Gene Symbol	PTPRC
Function	CD45 is a large transmembrane protein characterized by an heavily glycosylated extracellular domain, a single transmembrane helix, and an intracellular tyrosine phosphatase domain.
Molecular Weight	220 kDa
GeneCards	PTPRC
Human Protein Atlas	PTPRC
Associated Diseases	Alzheimer's disease, Parkinson's disease
Known Drugs/Compounds	TRETINOIN (ATRA)
Interactions	ALZHEIMER, AMYLOID, IL-6, NF-ΚB, PI3K, RNA
KG Connections	8 knowledge graph edges
Databases	GeneCards UniProt NCBI Gene HPA STRING

Wiki Pages (5)

Knowledge base pages for this entity

Pathway Diagram

flowchart TD
    PTPRC(["PTPRC"])
    ALZHEIMER(["ALZHEIMER"])
    AMYLOID(["AMYLOID"])
    IL_6(["IL-6"])
    NF__B(["NF-KappaB"])
    PI3K(["PI3K"])
    RNA(["RNA"])
    microglia["/"microglia"/"]

    ALZHEIMER -->|"interacts with"| PTPRC
    AMYLOID -->|"interacts with"| PTPRC
    IL_6 -->|"interacts with"| PTPRC
    NF__B -->|"interacts with"| PTPRC
    PI3K -->|"interacts with"| PTPRC
    RNA -->|"interacts with"| PTPRC
    microglia -->|"associated with"| PTPRC

    style PTPRC fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (0)

Target	Relation	Type	Str
No outgoing edges

Incoming (8)

Source	Relation	Type	Str
TRETINOIN (ATRA)	targets	drug	0.80
ALZHEIMER	interacts_with	gene	0.50
AMYLOID	interacts_with	gene	0.50
IL-6	interacts_with	protein	0.50
NF-ΚB	interacts_with	gene	0.50
PI3K	interacts_with	protein	0.50
RNA	interacts_with	gene	0.50
microglia	associated_with	cell_type	0.50

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

PTPRC

Understanding Entity Pages

Summary

Wiki Pages (5)

iPSC-Derived Microglia

PTPRD Protein

PTPRC Protein - Protein Tyrosine Phosphatase Receptor Type C