entity

RAC

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAC: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

3Connections

10Hypotheses

30Analyses

2Outgoing

1Incoming

Wiki Pages (20)

Knowledge base pages for this entity

Outgoing (2)

Target	Relation	Type	Str
neurodevelopmental disorders	implicated_in	disease	0.70
benchmark_ot_ad_answer_key:RAC	data_in	dataset_row	0.00

Incoming (1)

Source	Relation	Type	Str
benchmark_ot_ad_answer_key:RAC	data_in	dataset_row	0.00

Targeting Hypotheses (10)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
Closed-loop tACS targeting entorhinal cortex layer II SST in	0.625	Alzheimer's disease	Circuit-level neural dynamics in neurode
TBK1 Loss-of-Function Amplifies C1q-Mediated Synapse Elimina	0.520	neurodegeneration	How do the seven novel ALS genes functio
Fractalkine Axis Amplification via CX3CR1 Positive Allosteri	0.503	neurodegeneration	Synaptic pruning by microglia in early A
APOE-TREM2 Interaction Modulation	0.479	neurodegeneration	Mechanistic role of APOE in neurodegener
Interfacial Lipid Mimetics to Disrupt Domain Interaction	0.459	neurodegeneration	APOE4 structural biology and therapeutic

Pericyte Contractility Reset via Selective PDGFR-β Agonism	0.443	neurodegeneration	Perivascular spaces and glymphatic clear
Extracellular Matrix Stiffness Modulation	0.427	neurodegeneration	Microglia-astrocyte crosstalk amplificat
RAB27A-dependent extracellular vesicle engineering for mitoc	0.414	neurodegeneration	Mitochondrial transfer between astrocyte
Microglia-Derived Extracellular Vesicle Engineering for Targ	0.370	neurodegeneration	Mitochondrial transfer between neurons a
Extracellular Vesicle Biogenesis Modulation	0.340	Alzheimer's Disease	Tau propagation mechanisms and therapeut

Mentioning Analyses (30)

Scientific analyses that reference this entity

What are the precise temporal dynamics of astrocyte ketone production decline du

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.645

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.609

How does engineered C. butyricum cross the blood-brain barrier to directly bind

neurodegeneration | 2026-04-15 | 2 hypotheses Top: 0.675

What are the physiological functions of BACE1 beyond APP processing that could c

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.527

What upstream mechanisms trigger p53 activation specifically in response to poly

neurodegeneration | 2026-04-15 | 1 hypotheses Top: 0.562

Related Papers (20)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
Brain Capillary Ion Channels: Physiology and Channelopathies. [PMID:40748720]	Harraz OF, Hashad AM	Physiology (Bethesda)	2026	1
Targeting ECM-producing cells with CAR-T therapy alleviates fibrosis in chronic [PMID:40848726]	Zhao S, Li R, Xia Y, Wang X, Liu Z, Chu	Cell Stem Cell	2025	1
Stiffness sensing via Piezo1 enhances macrophage efferocytosis and promotes the [PMID:38838160]	Wang Y, Wang J, Zhang J, Wang Y, Wang Y,	Sci Adv	2024	1
Neurovascular unit, neuroinflammation and neurodegeneration markers in brain dis [PMID:39526043]	Kempuraj D, Dourvetakis KD, Cohen J, Val	Front Cell Neurosci	2024	1
The cell biology of APOE in the brain. [PMID:37805344]	Windham IA, Cohen S	Trends Cell Biol	2024	1
Tumour extracellular vesicles and particles induce liver metabolic dysfunction. [PMID:37225988]	Wang G, Li J, Bojmar L, Chen H, Li Z, To	Nature	2023	1
Extracellular vesicles in fatty liver promote a metastatic tumor microenvironmen [PMID:37172577]	Wang Z, Kim SY, Tu W, Kim J, Xu A, Yang	Cell Metab	2023	1
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central [PMID:37532007]	Zong B, Yu F, Zhang X, Pang Y, Zhao W, S	Ageing Res Rev	2023	1
The Genetics of Primary Familial Brain Calcification: A Literature Review. [PMID:37446066]	Chen SY, Ho CJ, Lu YT, Lin CH, Lan MY, T	Int J Mol Sci	2023	1
Fractalkine Enhances Hematoma Resolution and Improves Neurological Function via [PMID:37465997]	Chen X, He X, Xu F, Xu N, Sharifi NH, Zh	Stroke	2023	1
Targeting extracellular matrix stiffness and mechanotransducers to improve cance [PMID:35331296]	Jiang Y, Zhang H, Wang J, Liu Y, Luo T,	J Hematol Oncol	2022	1
Interplay of Low-Density Lipoprotein Receptors, LRPs, and Lipoproteins in Pulmon [PMID:35257044]	Calvier L, Herz J, Hansmann G	JACC Basic Transl Sci	2022	1
Microglia-Mediated Neuroinflammation: A Potential Target for the Treatment of Ca [PMID:35642214]	Wang M, Pan W, Xu Y, Zhang J, Wan J, Jia	J Inflamm Res	2022	1
CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. [PMID:34492237]	Subbarayan MS, Joly-Amado A, Bickford PC	Pharmacol Ther	2022	1
Mechanically activated ion channel Piezo1 modulates macrophage polarization and [PMID:34059671]	Atcha H, Jairaman A, Holt JR, Meli VS, N	Nat Commun	2021	1
Decoding myofibroblast origins in human kidney fibrosis. [PMID:33176333]	Kuppe C, Ibrahim MM, Kranz J, Zhang X, Z	Nature	2021	1
APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia. [PMID:33658354]	Sienski G, Narayan P, Bonner JM, Kory N,	Sci Transl Med	2021	1
APOE and Alzheimer's disease: advances in genetics, pathophysiology, and therape [PMID:33340485]	Serrano-Pozo A, Das S, Hyman BT	Lancet Neurol	2021	1
APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. [PMID:32376954]	Montagne A, Nation DA, Sagare AP, Barisa	Nature	2020	1
Alzheimer Disease: An Update on Pathobiology and Treatment Strategies. [PMID:31564456]	Long JM, Holtzman DM	Cell	2019	1

RAC

Understanding Entity Pages

Wiki Pages (20)

NTF4 Protein

Sphingolipid Metabolism in Neurodegeneration

WNT7A Gene

PAK3 — p21-Activated Kinase 3

PAK2 Protein (p21-Activated Kinase 2)

EPHA4 Gene

Wnt Signaling in Neurodegeneration

EFNB2 — Ephrin B2

GSK3B (Glycogen Synthase Kinase 3 Beta)

Sphingolipid Signaling Pathway in Neurodegeneration

fcgr2a-protein

RAC1 Gene

UNC5A — UNC-5 Netrin Receptor A

NTF5 — Neurotrophin 5

TREM2-SYK Signaling Cascade

SYK Kinase in Microglial Activation and Alzheimer's Disease

RACGAP1 — Rac GTPase Activating Protein 1

PIK3CG Gene

DOCK1 Gene

NCK2 Gene

Outgoing (2)

Incoming (1)

Targeting Hypotheses (10)

Mentioning Analyses (30)

What are the precise temporal dynamics of astrocyte ketone production decline du

Should microtubule-stabilizing drugs be reconsidered as therapeutic targets for

How does engineered C. butyricum cross the blood-brain barrier to directly bind

What are the physiological functions of BACE1 beyond APP processing that could c

What upstream mechanisms trigger p53 activation specifically in response to poly

Why does PRKN-mediated mitophagy, typically protective, cause harmful mitochondr

What molecular mechanisms cause iPLA2β deficiency to specifically damage mitocho

What molecular mechanisms enable Gal3 to enhance tau fibrillation upon binding t

What molecular mechanisms drive the transition from acute to persistent neuroinf

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

What molecular mechanisms mediate HDAC9's effects on Aβ deposition and synaptic

Why is TYROBP deficiency neuroprotective when TYROBP is an adapter for multiple

Does clusterin exacerbate or protect against neuronal death in neurodegeneration

What specific molecular mechanisms link APOE4 to cholesterol dysregulation in ol

How does pericyte senescence mechanistically promote glioma cell growth and inva

What genetic risk factors predispose individuals to developing CTE following rep

How does FUS loss-of-function in TAZ regulation contribute to ALS/FTD pathogenes

What molecular mechanisms determine whether reactive astrocytes adopt neurotoxic

How do P/Q channel deficits paradoxically increase thalamic excitability despite

Why does the V1613M variant reduce amyloid pathology when ABCA7 loss-of-function

What molecular mechanisms drive neuron-to-glioma synapse formation in high-neura

How do the seven novel ALS genes function in animal models to cause neurodegener

What molecular mechanisms enable microglia to neutralize OxPC-mediated neurodege

What molecular mechanisms underlie Atremorine's dramatic dopamine enhancement in

How does PIKFYVE inhibition activate unconventional protein clearance via exocyt

What mechanisms explain how IDH1/IDH2 mutations with reduced enzymatic activity

Why have anti-Aβ clinical trials failed despite the established role of Aβ in AD

Do β-amyloid plaques and neurofibrillary tangles cause or result from cholinergi

Extracellular vesicle biomarkers for early AD detection

Does structural 'normalization' of APOE4 domain interactions actually improve am

Related Papers (20)