gene 621 words KG: RAC2 2026-03-21
kind:genesection:genesstate:published
Contents

RAC2 — RAS-Related C3 Botulinum Toxin Substrate 2

🧬 Gene Info
Gene SymbolRAC2
Full NameRAS-Related C3 Botulinum Toxin Substrate 2
Chromosome22q13.1
FunctionRAC2 is a small GTPase belonging to the Rho family.
Primary Expressionhematopoietic cells but also has significant expression in the nervous system, particularly in neurons and [microglia](/cell-type
Molecular Weight21.4 kDa
Amino Acids192 aa
UniProt IDP15153
NCBI Gene ID5879
Ensembl IDENSG00000128340
OMIM602049
GeneCardsRAC2
Human Protein AtlasRAC2
Associated DiseasesAtherosclerosis, Ms
InteractionsCTSD, CDK4, CDKN1A, LCK, CD4, MAPK3
KG Connections36 knowledge graph edges
DatabasesGeneCardsHPASTRING

Knowledge Graph

Related Hypotheses (1)

SASP-Mediated Complement Cascade Amplification
Score: 0.70

Related Analyses (2)

Senolytic therapy for age-related neurodegeneration
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (10)

Proposed experiment from debate on Synaptic pruning by micro
falsification · proposed · Score: 0.40
Proposed experiment from debate on Senolytics targeting p16/
falsification · proposed · Score: 0.40
Mechanism: Why Does Amyloid Removal Only Slow Decline 27%?
clinical · proposed · Score: 0.40
Experiment: Autoimmune Hypothesis Testing in AD
clinical · proposed · Score: 0.40
Mixed Pathology Effects on Parkinson's Disease Progression a
clinical · proposed · Score: 0.40

See Also (15)

MAPK Signaling Pathways in Neurodegeneration
mechanism · KG edge: interacts_with
ZAP70 — Zeta Chain T-Cell Receptor Associated Protein K
gene · KG edge: interacts_with
TP53 Gene
gene · KG edge: interacts_with
MAPK3 Gene - ERK1
gene · KG edge: interacts_with
MAF - MAFA BZIP Transcription Factor
gene · KG edge: associated_with

Knowledge Graph (12 edges)

RAC2 associated_with CTSD
RAC2 associated_with MAF
RAC2 interacts_with CTSD
RAC2 interacts_with CDK4
RAC2 interacts_with CDKN1A
RAC2 interacts_with LCK
RAC2 associated_with COL1A1
RAC2 associated_with Ms
RAC2 associated_with Atherosclerosis
RAC2 regulates Ms