gene

RAD21

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about RAD21: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

8Connections

0Hypotheses

1Analyses

2Outgoing

6Incoming

0Experiments

1Debates

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🧬 Gene Info

Gene Symbol	RAD21
Full Name	Cohesin Complex Component in Neurodegeneration
Chromosome	8q24.11
Protein Type	Cohesin Complex Subunit
Function	Loading: Cohesin is loaded onto DNA by the Scc2/4 complex during early S phase
Amino Acids	581 aa
UniProt ID	Q9UQE5
NCBI Gene ID	11124
Ensembl ID	ENSG00000164754
OMIM	606462
GeneCards	RAD21
Human Protein Atlas	RAD21
Phosphorylation	By Polo-like kinases and Aurora B for proper chromosome behavior
Acetylation	By Eco1/Ctf7 during S phase for establishment of cohesion
Proteolytic cleavage	By separase (ESPL1) during anaphase to allow sister chromatid separation
Associated Diseases	Als
KG Connections	8 knowledge graph edges
Databases	GeneCards HPA STRING

🔮 Predicted Structure: RAD21 — AlphaFold Q9UQE5 Click to expand

AI-predicted structure from AlphaFold | Powered by Mol*

Wiki Pages (1)

Knowledge base pages for this entity

Canonical Page

RAD21 — Cohesin Complex Component in Neurodegeneration

gene · 3046 words

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Pathway Diagram

flowchart TD
    RAD21(["RAD21"])
    Als["Als"]
    SMC1A(["SMC1A"])
    ANKRD11(["ANKRD11"])
    NIPBL(["NIPBL"])
    HDAC8(["HDAC8"])
    SMC3(["SMC3"])
    BRD4(["BRD4"])
    neurodegeneration["neurodegeneration"]

    RAD21 -->|"associated with"| Als
    SMC1A -->|"associated with"| RAD21
    ANKRD11 -->|"associated with"| RAD21
    NIPBL -->|"associated with"| RAD21
    HDAC8 -->|"associated with"| RAD21
    SMC3 -->|"associated with"| RAD21
    BRD4 -->|"associated with"| RAD21
    RAD21 -->|"implicated in"| neurodegeneration

    style RAD21 fill:#1a237e,stroke:#4fc3f7,stroke-width:3px,color:#fff

Outgoing (2)

Target	Relation	Type	Str
TAD boundary function	regulates	phenotype	0.70
Als	associated_with	disease	0.65

Incoming (6)

Source	Relation	Type	Str
SMC1A	associated_with	gene	0.60
ANKRD11	associated_with	gene	0.60
NIPBL	associated_with	gene	0.60
HDAC8	associated_with	gene	0.60
SMC3	associated_with	gene	0.60
BRD4	associated_with	gene	0.60

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (1)

Scientific analyses that reference this entity

Do different priming stimuli create distinct chromatin landscapes or converge on

epigenetics | 2026-04-10 | 3 hypotheses

Experiments (0)

Experimental studies targeting or related to this entity

Experiment	Type	Disease	Score	Feasibility	Model	Status	Est. Cost
No experiments found

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

Debates (1)

Multi-agent debates referencing this entity

The debate presented conflicting evidence for convergent vs. stimulus-specific c

closed · Rounds: 4 · Score: 0.30 · 2026-04-21

Related Research

Hypotheses and analyses mentioning RAD21 in their description or question text

No additional research found