gene 3,046 words KG: RAD21
Contents

RAD21 — Cohesin Complex Component in Neurodegeneration

🧬 Gene Info
Gene SymbolRAD21
Full NameCohesin Complex Component in Neurodegeneration
Chromosome8q24.11
Protein TypeCohesin Complex Subunit
FunctionLoading: Cohesin is loaded onto DNA by the Scc2/4 complex during early S phase
Amino Acids581 aa
UniProt IDQ9UQE5
NCBI Gene ID11124
Ensembl IDENSG00000164754
OMIM606462
GeneCardsRAD21
Human Protein AtlasRAD21
PhosphorylationBy Polo-like kinases and Aurora B for proper chromosome behavior
AcetylationBy Eco1/Ctf7 during S phase for establishment of cohesion
Proteolytic cleavageBy separase (ESPL1) during anaphase to allow sister chromatid separation
Associated DiseasesAls
KG Connections8 knowledge graph edges
DatabasesGeneCardsHPASTRING

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🌐 Cross-references

NCBI GeneUniProtGeneCardsWikipediaHGNCEnsembl

Related Hypotheses (2)

Chromatin Accessibility Restoration via BRD4 Modulation
Score: 0.77
Astrocyte-Mediated Neuronal Epigenetic Rescue
Score: 0.73

Related Analyses (2)

Epigenetic reprogramming in aging neurons
neurodegeneration · archived
Circuit-level neural dynamics in neurodegeneration
neuroscience · archived

Related Experiments (4)

Cognitive Reserve Mechanisms in Alzheimer's Disease — Molecu
clinical · completed · Score: 0.40
Epigenetic Dysregulation in Huntington's Disease — Therapeut
validation · completed · Score: 0.40
Epigenetic Dysregulation Validation in Parkinson's Disease
clinical · proposed · Score: 0.40
Epigenetic Regulation Dysfunction in Alzheimer's and Parkins
clinical · proposed · Score: 0.40

See Also (8)

Neurodegeneration
disease · KG edge: implicated_in
ANKRD11 — Ankyrin Repeat Domain 11
gene · KG edge: associated_with
BRD4 (Bromodomain-Containing Protein 4)
gene · KG edge: associated_with
HDAC8 Gene
gene · KG edge: associated_with
NIPBL - Nipped-B Like (Cohesin Loader)
gene · KG edge: associated_with

Knowledge Graph (8 edges)

SMC1A associated_with RAD21
ANKRD11 associated_with RAD21
NIPBL associated_with RAD21
HDAC8 associated_with RAD21
SMC3 associated_with RAD21
BRD4 associated_with RAD21
RAD21 associated_with Als
RAD21 regulates TAD boundary function

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