Entity Detail — Knowledge Graph Node
This page aggregates everything SciDEX knows about SMC1A: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.
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| Name | SMC1A |
| Summary | Page for SMC1A |
| Key Genes/Proteins | STMN1, AKT, ANKRD11, NIPBL, HDAC8, SMC3 |
| Related Diseases | Cornelia de Lange syndrome, developmental and epileptic encephalopathy, breast cancer, colorectal cancer, intellectual disability |
Knowledge base pages for this entity
graph TD
SMC1A["SMC1A"]
SMC1A -->|"causes"| Cornelia_de_Lange_syndrome["Cornelia de Lange syndrome"]
SMC1A -->|"causes"| developmental_and_epileptic_en["developmental and epileptic encephalopathy"]
SMC1A -->|"upregulates"| FOXM1["FOXM1"]
SMC1A -->|"regulates"| STMN1["STMN1"]
SMC1A -->|"activates"| AKT["AKT"]
SMC1A -->|"causes"| breast_cancer["breast cancer"]
SMC1A -->|"upregulates"| systemic_lupus_erythematosus["systemic lupus erythematosus"]| Target | Relation | Type | Str |
|---|---|---|---|
| Cornelia de Lange syndrome | causes | disease | 0.90 |
| developmental and epileptic encephalopathy | causes | disease | 0.90 |
| STMN1 | regulates | protein | 0.80 |
| AKT | activates | protein | 0.80 |
| breast cancer | causes | disease | 0.80 |
| colorectal cancer | associated_with | disease | 0.80 |
| intellectual disability | associated_with | phenotype | 0.80 |
| epilepsy | associated_with | disease | 0.80 |
| systemic lupus erythematosus | upregulates | disease | 0.80 |
| Als | associated_with | disease | 0.65 |
| ANKRD11 | associated_with | gene | 0.60 |
| NIPBL | associated_with | gene | 0.60 |
| HDAC8 | associated_with | gene | 0.60 |
| SMC3 | associated_with | gene | 0.60 |
| BRD4 | associated_with | gene | 0.60 |
| RAD21 | associated_with | gene | 0.60 |
| Source | Relation | Type | Str |
|---|---|---|---|
| No incoming edges | |||
Hypotheses where this entity is a therapeutic target
| Hypothesis | Score | Disease | Analysis |
|---|---|---|---|
| No targeting hypotheses | |||
Scientific analyses that reference this entity
No analyses mention this entity
Scientific publications cited in analyses involving this entity
| Title & PMID | Authors | Journal | Year | Citations |
|---|---|---|---|---|
| No papers found | ||||