gene

HDAC8

Entity Detail — Knowledge Graph Node

Understanding Entity Pages

This page aggregates everything SciDEX knows about HDAC8: its mechanistic relationships (Knowledge Graph edges), hypotheses targeting it, analyses mentioning it, and supporting scientific papers. The interactive graph below shows its immediate neighbors. All content is AI-synthesized from peer-reviewed literature.

146Connections

0Hypotheses

0Analyses

50Outgoing

50Incoming

Summary

Page for HDAC8 Gene

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🧬 Gene Info

Gene Symbol	HDAC8
Full Name	HDAC8
Chromosome	Xq13.1
Protein Type	Gene
Function	encodes a zinc-dependent class I histone deacetylase enzyme that plays a critical role in epigenetic regulation of gene expression.
Primary Expression	various tissues, with significant expression in the brain where it regulates chromatin structure and gene transcription essential for neuronal develop
Molecular Weight	42 kDa
Amino Acids	377 aa
Exons	14
Pathways	NF-κB, NF-κB pathway
NCBI Gene ID	Search NCBI
GeneCards	HDAC8
Human Protein Atlas	HDAC8
Associated Diseases	Als, Alzheimer
Interactions	HDAC3, HDAC1, HDAC2, NEK1, Rb, BAX
KG Connections	146 knowledge graph edges
Databases	GeneCards UniProt HPA STRING

Wiki Pages (16)

Knowledge base pages for this entity

Canonical Page

Pathway Diagram

graph TD
    HDAC8["<b>HDAC8</b>"]
    Inflammation{"Inflammation"}
    HDAC8 -->|"protects_against"| Inflammation
    Neuroinflammation{"Neuroinflammation"}
    HDAC8 -->|"protects_against"| Neuroinflammation
    Ms{"Ms"}
    HDAC8 -.->|"inhibits"| Ms
    Glaucoma{"Glaucoma"}
    HDAC8 -->|"protects_against"| Glaucoma
    INFLAMMATION(["INFLAMMATION"])
    HDAC8 -->|"protects_against"| INFLAMMATION
    Oxidative_Stress["Oxidative Stress"]
    HDAC8 -->|"activates"| Oxidative_Stress
    JNK(["JNK"])
    JNK -->|"protects_against"| HDAC8
    MAPK(["MAPK"])
    MAPK -->|"protects_against"| HDAC8
    OXIDATIVE_STRESS(["OXIDATIVE STRESS"])
    OXIDATIVE_STRESS -->|"activates"| HDAC8
    S100B(["S100B"])
    S100B -->|"protects_against"| HDAC8
    style HDAC8 fill:#1a3a4a,stroke:#ce93d8,stroke-width:3px,color:#ce93d8

Outgoing (90)

Target	Relation	Type	Str
histone acetylation	suppresses	process	0.90
Inflammation	protects_against	disease	0.65
Neuroinflammation	protects_against	disease	0.65
Ms	inhibits	disease	0.65
Glaucoma	protects_against	disease	0.65
Alzheimer	expressed_in	disease	0.65
Als	expressed_in	disease	0.65
Als	associated_with	disease	0.65
Cancer	inhibits	disease	0.65
Cancer	therapeutic_target	disease	0.65
Fibrosis	inhibits	disease	0.65
Als	regulates	disease	0.65
Cancer	regulates	disease	0.65
Als	inhibits	disease	0.65
HDAC2	expressed_in	gene	0.60
HDAC3	expressed_in	gene	0.60
HDAC1	expressed_in	gene	0.60
NEK1	activates	gene	0.60
Stat3	expressed_in	protein	0.60
SMC3	associated_with	gene	0.60
BRD4	associated_with	gene	0.60
RAD21	associated_with	gene	0.60
HDAC6	therapeutic_target	gene	0.60
HDAC2	therapeutic_target	gene	0.60
HDAC3	therapeutic_target	gene	0.60
HDAC1	therapeutic_target	gene	0.60
Jnk	protects_against	protein	0.60
Rb	inhibits	protein	0.60
BAX	inhibits	gene	0.60
Bcl-2	inhibits	protein	0.60
Stat3	inhibits	protein	0.60
STAT3	inhibits	gene	0.60
PRKN	activates	gene	0.60
RELA	activates	gene	0.60
PRKN	inhibits	gene	0.60
RELA	inhibits	gene	0.60
Notch signaling	participates_in	pathway	0.60
INFLAMMATION	protects_against	gene	0.60
Oxidative Stress	activates	pathway	0.60
Mapk	protects_against	pathway	0.60
WNT	regulates	gene	0.60
DNA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
Epigenetic	expressed_in	pathway	0.60
Wnt	regulates	pathway	0.60
Synaptic Plasticity	regulates	pathway	0.60
App	inhibits	protein	0.60
T Cell	expressed_in	cell_type	0.60
Fus	expressed_in	protein	0.60
App	therapeutic_target	protein	0.60

Incoming (56)

Source	Relation	Type	Str
HSV-gB	upregulates	protein	0.85
JNK	protects_against	gene	0.60
S100B	protects_against	gene	0.60
HDAC3	expressed_in	gene	0.60
HDAC1	expressed_in	gene	0.60
HDAC2	expressed_in	gene	0.60
STAT3	expressed_in	gene	0.60
PDK4	expressed_in	gene	0.60
SMC1A	associated_with	gene	0.60
ANKRD11	associated_with	gene	0.60
NIPBL	associated_with	gene	0.60
SMC3	inhibits	gene	0.60
MMP12	inhibits	gene	0.60
PARP1	inhibits	gene	0.60
MRE11	inhibits	gene	0.60
STAT3	inhibits	gene	0.60
HDAC1	regulates	gene	0.60
HDAC2	regulates	gene	0.60
HDAC3	regulates	gene	0.60
HDAC1	interacts_with	gene	0.60
HDAC2	interacts_with	gene	0.60
HDAC3	interacts_with	gene	0.60
HDAC3	associated_with	gene	0.60
HDAC3	binds_to	gene	0.60
BDNF	activates	gene	0.60
HDAC3	activates	gene	0.60
HDAC3	inhibits	gene	0.60
HDAC6	inhibits	gene	0.60
HDAC1	inhibits	gene	0.60
MAPK	protects_against	gene	0.60
OXIDATIVE STRESS	activates	gene	0.60
NEUROINFLAMMATION	protects_against	gene	0.60
AND	inhibits	gene	0.60
ERK	protects_against	gene	0.60
DNA	expressed_in	gene	0.60
ALZHEIMER	expressed_in	gene	0.60
WNT	regulates	gene	0.60
AND	expressed_in	gene	0.60
ALZHEIMER'S DISEASE	expressed_in	gene	0.60
RNA	expressed_in	gene	0.60
HDAC	therapeutic_target	gene	0.60
HDAC	inhibits	gene	0.60
RNA	activates	gene	0.60
BCL-2	inhibits	gene	0.60
P21	inhibits	gene	0.60
DNA	activates	gene	0.60
HDAC1	protects_against	gene	0.55
HDAC2	protects_against	gene	0.55
HDAC3	protects_against	gene	0.55
HDAC	associated_with	gene	0.55

Targeting Hypotheses (0)

Hypotheses where this entity is a therapeutic target

Hypothesis	Score	Disease	Analysis
No targeting hypotheses

Mentioning Analyses (0)

Scientific analyses that reference this entity

No analyses mention this entity

Related Papers (0)

Scientific publications cited in analyses involving this entity

Title & PMID	Authors	Journal	Year	Citations
No papers found

HDAC8

Understanding Entity Pages

Summary

Wiki Pages (16)

HDAC8 Gene

Epigenetic Dysregulation in Neurodegeneration

HDAC7 Protein

Lactate Lactylation in Neurodegeneration

HDAC5 Protein

ANKRD11 — Ankyrin Repeat Domain 11

HDAC5 Gene

Histone Deacetylase (HDAC) Enzymes

SMC1A

HDAC Inhibitors for Neurodegeneration — Investment Landscape

Histone Deacetylases (HDACs)

NIPBL - Nipped-B Like (Cohesin Loader)

SMC3 - Structural Maintenance of Chromosomes 3

HDAC8 Protein